The invention relates to the technical field of petroleum drilling, and discloses a reservoir protection agent intermediate product, a reservoir protection agent, preparation methods and applications thereof, as well as drilling fluid and an application thereof. The reservoir protection agent intermediate product is prepared by the following raw materials: acrylamide, a cationic monomer, a cross-linking agent, an initiator, a toughening material and water, based on 100 parts by weight of the raw materials, the raw materials comprise the following components in parts by weight: 8-30 parts of acrylamide, 1-10 parts of the cationic monomer, 0.01-0.5 parts of the cross-linking agent, 0.01-0.1 parts of the initiator, and 5-25 parts of the toughening material. The reservoir protection agent comprises the intermediate product, alkali, salt and water, based on 100 parts by weight of the reservoir protection agent, the reservoir protection agent comprises 5-40 parts by weight of the intermediate product, 1-10 parts of alkali, and 1-12 parts by weight of salt. The reservoir protection agent has good sealing effects, improves reservoir protection capability of drilling fluid, and enhances capability of drilling fluid for stabilization of borehole walls.