The invention discloses a low-modulus monocomponent de-ketoxime type room temperature sulfurized silicone sealant and a preparation method thereof. The silicon sealant is prepared from hydroxyl end-blocked dimethylsiloxane, a plasticizer, white mineral oil, gas phase method silica aerogel, a reinforcing filler, aluminum stearate, pigment, a crosslinking agent, a vulcanization accelerator, a silane coupling agent and a catalyst. The preparation method comprises the following steps: 1) uniformly mixing the hydroxyl end-blocked dimethylsiloxane, the plasticizer, the white mineral oil, the gas phase method silica aerogel, the reinforcing filler, the aluminum stearate and the pigment, and drying the mixture fully to obtain a premix compound; 2) performing vacuum full kneading on the premix compound to obtain base; 3) adding the crosslinking agent, the vulcanization accelerator and the silane coupling agent into the base, performing vacuum stirring uniformly;4) adding the catalyst into the base, performing vacuum stirring uniformly, discharging the mixture, and performing filling and sealing. The low-modulus monocomponent de-ketoxime type room temperature sulfurized silicone sealant provided by the invention has the advantages of neutral solidification, strong bonding power, excellent mechanical property, and good heat resistance and oil resistance.