The invention relates to an anti-wrinkle tidying method for a pure cotton fabric, sequentially comprising the following processes: shell fabric preparation, pre-limbering, resin padding, curing, rinsing, post-limbering and preshrinking. The method has the main technical characteristic that the padding formula used in the resin padding process comprises the following components by concentration: 80-120g/L of 2D resin, 80-100g/L of oxalaldehyde resin, 40g/L of 1,3-Dimethylurea, 40g/L of magnesium chloride activated by organic acid, 20-40g/L of brute-force protective agent, 1-2g/L of penetrating agent and the balance of water. The invention has reasonable design, and fully utilizes the advantages of two types of the resins and catalysts; the tidied pure cotton fabric has the characteristics of higher planeness, higher brute force, favorable abrasive resistance, lower formaldehyde content and the like; and the garment made of the tidied pure cotton fabric has the characteristics of comfortable wearing, beautiful appearance and strong durability.