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56 results about "Heat stabilization" patented technology

Heat stabilization is an additive-free preservation technology for tissue samples which stops degradation and changes immediately and permanently. Heat stabilization uses rapid conductive heating, under controlled pressure, to generate a fast, homogenous and irreversible thermal denaturation of proteins, resulting in a complete and permanent elimination of all enzymatic activity that would otherwise cause further biological changes to the tissue sample ex vivo. Due to the permanent inactivation of enzymes, heat stabilization overcomes the drawbacks of conventional tissue sample preservation techniques, such as snap-freezing followed by inhibitors.

Thermostable embedding method and application of alpha-amylase inhibitor

The invention belongs to the technical field of food additives and new materials, and discloses a thermostable embedding method and application of an alpha-amylase inhibitor, and the method comprises the following steps: respectively adjusting the pH values of an alpha-AL stock solution and an iota-CG stock solution to 6, then mixing the stock solutions according to the mass ratio of alpha-AL to iota-CG of 2: 1, and carrying out heat preservation for 2-3 hours, so as to obtain the thermostable embedding method of the alpha-amylase inhibitor. According to the method disclosed by the invention, the stable ion compound is formed under the condition that the pH is equal to 6 by utilizing the electrostatic interaction and the hydrogen-bond interaction between the negatively charged sulfuric acid group in the iota-carrageenan molecule and the positively charged amino acid residue on the surface of the white kidney bean alpha-amylase inhibitor. According to the compound, stable combination among molecules is achieved by constructing a structured water molecular layer barrier, so that the tolerance of the white kidney bean alpha-amylase inhibitor to heat treatment is remarkably improved, and the defect that the heat stability of the white kidney bean alpha-amylase inhibitor is poor is overcome.
Owner:ZHEJIANG UNIV

A composition, reagent and method of detection thereof for high-throughput genetic sequencing

PendingCN122629187AMultiplexQuinoline
The application discloses a kind of compositions, reagents and its detection method for high-throughput gene sequencing, belong to gene sequencing technical field, the composition includes Tris-HCl buffer 80-120 parts, potassium chloride 40-60 parts, ammonium sulfate 10-20 parts, magnesium chloride 15-25 parts, dNTPs mixed solution 30-50 parts, heat-stable DNA polymerase mutant 8-15 parts, PCR promoter complex 5-12 parts, modified iridium quinoline ketone complex 1-5 parts, glycerol 150-250 parts, Tween-20 1-3 parts, EDTA disodium salt 0.5-2 parts and nuclease-free ultrapure water, by introducing the modified iridium quinoline ketone complex of innovation, effectively solve the technical problems of low amplification efficiency, poor multiplex PCR reaction uniformity and high non-specific amplification background for high GC content, complex secondary structure genomic template, significantly improve the specificity of amplification, uniformity and the quality and reliability of final sequencing data.
Owner:JIAMUSI UNIVERSITY

Conductive pet film material for transparent antenna and method for manufacturing the same

The application relates to the technical field of PET film, and discloses a conductive PET film material for a transparent antenna and a preparation method thereof, wherein the conductive PET film material comprises, from top to bottom, a copper mesh and a PET film; the PET film comprises the following components by weight: 80-90 parts of PET resin, 1-2 parts of a compatilizer, 8-14 parts of a flame retardant, 2-4 parts of an ultraviolet resistance agent and 0.8-1 part of a heat stabilizer; the flame retardant is composed of an organic phosphorus flame retardant and 4-amino-5-imidazole formamide. Through the technical scheme, the problems of poor flame retardance and ultraviolet resistance of the conductive PET film material in the related art are solved.
Owner:人天通信集团有限公司

A basic xylanase mutant with improved specific activity and thermostability and a preparation method thereof

The application discloses a basic xylanase mutant with improved specific enzyme activity and thermal stability and a preparation method thereof, and belongs to the field of genetic engineering and enzyme engineering. The application provides a basic xylanase mutant M22 through a semi-rational design method, wherein the specific enzyme activity of the mutant M22 is 211 U / mg, which is increased by 181.33% compared with that of a wild type. After 30 min of heat treatment at 75 DEG C, the residual activity of the mutant M22 relative to the wild type is 169.30%, and after treatment at 80 DEG C, 85 DEG C and 90 DEG C, the relative residual activities of the mutant M22 are 153.94%, 127.84% and 115.02% respectively relative to the wild type treated at 75 DEG C for 30 min. The basic xylanase mutant M22 obtained by the application has significantly improved specific enzyme activity and stability compared with the wild type, and has higher application value and potential in industrial production.
Owner:SOUTH CHINA UNIV OF TECH

Method for producing carbon-rich material

A method of producing a carbon-rich material, the method comprising the steps of: a) providing a lignin bead, wherein the lignin bead comprises at least 80 wt% of lignin, based on the dry weight of the lignin bead; b) optionally heating the lignin bead to one or more temperatures in the range of 140 to 270 °C for a period of at least 30 minutes to obtain a heat-stabilized lignin bead; and c) subjecting the optionally heat-stabilized lignin bead to carbonization at one or more temperatures in the range of 300 °C to 1500 °C, wherein the carbonization is carried out for a total time in the range of 30 minutes to 10 hours, so as to obtain a carbon-rich material.
Owner:STORA ENSO OYJ

Gravimeter temperature control system modeling control method

The invention discloses a gravimeter temperature control system modeling control method, and relates to the technical field of precise instrument temperature control, and the method comprises the steps: 1, obtaining the real-time running speed of a carrier, the wind speed of an external environment, and the current temperature of a core part of a gravimeter; step 2, feed-forward compensation power is calculated based on the real-time driving speed and the external environment wind speed according to preset dynamic thermal disturbance model parameters; 3, based on the difference value between the current temperature and the preset target temperature, feedback control power is calculated through a preset feedback control algorithm; 4, superposing the feed-forward compensation power and the feedback control power to generate total control power, and outputting the total control power to control the heating actuator. Predictive disturbance compensation is achieved, temperature overshoot is effectively restrained, the thermal stabilization time is remarkably shortened, the operation efficiency is improved, the data quality is improved, the measurement reliability is enhanced, and the method is suitable for large-scale popularization and application. Practicality is high, compatibility is good, and upgrading and reconstruction are easy.
Owner:BEIJING AODI PROBING INSTR CO LTD

Equipment for testing heat stabilizer in PVC (Polyvinyl Chloride)

The utility model relates to the technical field of mobile phone shell detection equipment, in particular to equipment for testing a heat stabilizer in PVC (polyvinyl chloride), which comprises an L-shaped plate, a test box is fixedly mounted on the outer wall of one side of the L-shaped plate, and a moving mechanism is arranged at the top of the L-shaped plate. By arranging the mounting mechanism, during use, the PVC block is placed in the protective frame in the mounting box, the cover turning plate covers the PVC block, then the mounting box is mounted in the open slot, and the limiting column is clamped with the mounting box under the action of the spring, so that when the mounting box is fixed and dismounted, only the push block needs to be pushed, the limiting column moves, and the PVC block can be fixed and dismounted. The mounting box is convenient and rapid to mount and dismount, a worker can conveniently sample the PVC block, the dismounting and mounting efficiency is greatly improved, and meanwhile, a heat conduction block is arranged in the turning cover plate, so that heat concentration is facilitated, and the PVC block is conveniently and rapidly heated to a proper temperature.
Owner:ANHUI SUSHENG NEW MATERIALS CO LTD

Modified ETFE material and application thereof

The invention discloses a modified ETFE material and application thereof, and the modified ETFE material comprises 90-100 parts by mass of ETFE, 0.5-2 parts by mass of an anti-ultraviolet agent, 0.2-0.6 part by mass of an antioxidant, 0.2-1 part by mass of a light stabilizer, 0.2-1 part by mass of a heat stabilizer, 0.5-10 parts by mass of modified ATO and 3-12 parts by mass of a coupling agent. The modified ETFE material provided by the invention has the characteristics of excellent mechanical strength, weather resistance, self-cleaning property and the like, also has excellent infrared barrier property, and is particularly suitable for being applied to preparation of ETFE films for high infrared barrier buildings.
Owner:NIFLON MACROMOLECULAR MATERIAL (SH) CO LTD

Novel composite phase change heat storage medium and preparation method thereof

The invention discloses a novel composite phase change heat storage medium and a preparation method thereof, and is characterized in that the novel composite phase change heat storage medium comprises the following substances by weight: 70-75 parts of a phase change energy storage material, 0-8 parts of a heat conduction reinforcing material, 0-15 parts of a water sealing material, 5-10 parts of a modified material, 0-20 parts of a gel material, and 0-10 parts of deionized water. On the one hand, the composite phase change heat storage medium produced through reasonable component composition under specific production and processing conditions has the advantages of being good in heat stability, free of supercooling and phase separation phenomena, large in heat storage density, high in heat conductivity, not prone to volatilization of all component materials and the like;
Owner:GUIZHOU YAOTIAN TECH CO LTD

Method for calculating combination of perfluoroalkyl and polyfluoroalkyl compounds and PPAR alpha based on pharmacophore model

The invention relates to the technical field of computational toxicology, and discloses a method for calculating combination of perfluorinated and polyfluorinated alkyl compounds and PPARalpha based on a pharmacophore model, which comprises the following steps: acquiring a PFAS initial data set, acquiring a PPARalpha ligand binding domain crystal structure, and optimizing the structure; selecting representative PFAS to carry out molecular docking, and carrying out simulated annealing optimization to obtain an optimal binding posture; then generating a pharmacophore model; the models are screened; performing rigid fitting screening by using a pharmacophore model; carrying out molecular dynamics simulation on the representative hit object, and verifying the stability; protein is extracted by culturing cells in vitro, a thermal displacement experiment is carried out, and the thermal stability effect of PFAS on PPARalpha is verified. According to the method, comprehensive virtual screening of PFAS-PPAR alpha interaction based on pharmacophores is provided, a calculation framework based on protein and compound structures is established, and the method is suitable for environmental pollutant screening and safer chemical design.
Owner:MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV

Heat-resistant biodegradable film-making material and production process thereof

The invention discloses a heat-resistant biodegradable film-making material, which is prepared from the following ingredients in parts by mass: 30 to 60 parts of modified polylactic acid, 20 to 35 parts of toughening agents, 10 to 18 parts of multifunctional modifiers, 0.4 to 1.4 parts of nucleating agents, 3 to 5 parts of plasticizers and 0.3 to 0.8 part of bio-based chain extenders. 0.3-10 parts of a composite heat stabilizer and 4-15 parts of an antibacterial agent; the modified polylactic acid is prepared from the following components in parts by mass: 35 to 50 parts of polylactic acid, 5 to 25 parts of polypropylene carbonate, 1 to 6 parts of micromolecular compatilizer and 0.2 to 2 parts of initiator. And the modified polylactic acid improves the biodegradation rate. The heat-resistant biodegradable film-making material disclosed by the invention has excellent temperature resistance, degradability, mechanical strength and toughness, can be widely applied to various industries, and has good application and market prospects. The invention also discloses a production process of the heat-resistant biodegradable film-making material.
Owner:ZHEJIANG WENWU SOFT-PACKING TECH CO LTD

Production of biological scalable nanorods

PendingUS20250304919A1Virus peptidesBiological material analysisSite-specific recombinationCell biology
Disclosed herein are nanorod productions systems (NPS) useful for the production of biological scalable functionalization-ready nanorods (BSFnano). The nanorods produced are derived from filamentous phage Ff (f1, M13 or fd). The NPS disclosed herein permits efficient biological production of non-infectious, heat-stable isomorphic proteinaceous nanorods comprising modifications allowing site-specific recombinant, chemical and enzymatic attachment of peptide and non-peptide functionalities in an orthogonal manner. Also disclosed are methods of making and using these nanorods, such as in methods of detecting target molecules.
Owner:MASSEY VENTURES LTD

Thermal stable type KGF-2 based on AI optimization molecule free energy and generation method and device of thermal stable type KGF-2

The invention relates to a thermally stable KGF-2 derivative based on artificial intelligence optimization of overall free energy of molecules, and a generation method, device and application thereof. The thermostable KGF-2 derivative is obtained by mutating a phenylalanine residue at the 167th site of wild type KGF-2 into a leucine residue, and / or mutating an alanine residue at the 185th site of the wild type KGF-2 into an isoleucine residue, and removing amino acid residues at the 2nd-68th sites, and the amino acid sequence of the thermostable KGF-2 derivative is as shown in SEQ ID NO: 4, SEQ ID NO: 6 or SEQ ID NO: 8. According to the scheme provided by the invention, free energy simulation calculation can be carried out on the KGF-2 protein molecules to obtain a heat-stable KGF-2 derivative structure with relatively low free energy and even an optimal heat-stable KGF-2 derivative structure, so that the stability of the KGF-2 protein molecules is improved.
Owner:SHENZHEN NEWROSETTA BIOSCIENCES CO LTD

Photo-thermal-thermoelectric synergistic material, photo-thermal-thermoelectric synergistic composite material, preparation method and application thereof

ActiveCN122251675BEndogenyWireless
The present application relates to photothermal-thermoelectric synergistic material, photothermal-thermoelectric synergistic composite material, preparation method and application thereof, the photothermal-thermoelectric synergistic material includes bismuth selenide-gold composite material, bismuth selenide-gold composite material is hexagonal, gold material is located in the central hexagon.The advantage lies in, gold nanoparticles located in the center of hexagon are used as "heat source core", under the excitation of near infrared light, stable radial temperature gradient is formed with the base bismuth selenide, and then endogenous micro-current is generated based on the Seebeck effect of bismuth selenide, this wireless, non-invasive "photothermal-stable temperature difference-thermoelectric" cascade signal can effectively simulate the bioelectric environment of bone tissue, and the osteogenic differentiation of bone marrow mesenchymal stem cells is significantly promoted;The photothermal-thermoelectric synergistic material of the present application can effectively remove active oxygen, and has good antioxidant property.
Owner:SHANGHAI TENTH PEOPLES HOSPITAL

Horizontal pipe evaporation concentrator

ActiveCN223683044UEvaporator accessoriesEvaporators with horizontal tubesHeating effectCirculating pump
The utility model discloses a horizontal pipe evaporation concentrator, which comprises a separator, the separator comprises a hollow shell, a live steam inlet, a condensate water outlet, a material inlet, a concentrated solution outlet and a secondary steam outlet are arranged on the shell, a heater and a spraying assembly are arranged in the shell, the spraying assembly comprises a spraying pipe and a nozzle, the heater comprises a horizontal heating pipe, and the nozzle is arranged in the shell. The plurality of heating pipes are sequentially communicated to form a snakelike heating channel; a feeding pump and a circulating pump; and a condensation assembly. According to the horizontal pipe evaporation concentrator, the spraying assembly and the heater are concentrated in the separator, the compactness of the equipment structure is guaranteed, the occupied space is reduced, feed liquid is sprayed to the heating pipe into which live steam is introduced through the spraying assembly, so that the feed liquid flows down in a film shape under gravity, heat transfer is promoted, meanwhile, it is guaranteed that the feed liquid is heated stably and uniformly, and the efficiency is improved. Therefore, the heating effect is improved.
Owner:JIANGYIN JIANGZHONG EQUIP MFG

Heat-stable DNA polymerases and reverse transcriptases

The present invention relates to mutated DNA polymerases derived from wild-type Thermus aquaticus (Taq) DNA polymerase, methods for reverse transcription polymerase chain reaction (RT-PCR) using said DNA polymerases, and kits comprising said DNA polymerases.
Owner:QIAGEN GMBH

Preparation system and method of cross-linking agent for fracturing

The invention relates to the technical field of preparation of cross-linking agents for fracturing, and discloses a preparation system and method of a cross-linking agent for fracturing, and the system comprises a preparation module which is used for enabling a plurality of raw materials to generate a chemical reaction by adjusting the reaction temperature and the mixing rate to generate the cross-linking agent; the detection module is connected with the preparation module and is used for receiving the cross-linking agent and detecting quality parameters such as the cross-linking viscosity, the initial cross-linking time, the thermal stability temperature and the shearing residue rate of the cross-linking agent; the central control module is connected with the preparation module and the detection module through a data link, and is used for judging the performance grade of the cross-linking agent of the batch based on the cross-linking viscosity peak value detected by the detection module and a preset viscosity parameter interval, and determining the performance grade of the cross-linking agent of the batch according to at least one of the cross-linking viscosity peak value, the thermal stability temperature and the shear residue rate when the performance grade is judged to be a non-superior grade. And parameters of the next batch of preparation process are subjected to self-adaptive adjustment, so that performance grading monitoring and self-adaptive optimization regulation and control in the production process of the cross-linking agent for fracturing are realized.
Owner:CHIFENG AOLONG CHEM CO LTD

Dynamic thermal stability extrusion processing device and method

PendingCN121375070AThermodynamicsCooling pipe
The invention relates to the technical field of extruders, in particular to a dynamic thermal stability extrusion processing device and method.The dynamic thermal stability extrusion processing device comprises charging barrel units, and at least three charging barrel units are sequentially connected in the axial direction to form a charging barrel structure of an extruder; a heating unit is arranged on the outer wall of each charging barrel unit; a cooling channel is arranged on the inner wall of the charging barrel unit, and the cooling channel is distributed between the heating unit and the inner wall of the charging barrel unit; and a conveying pipeline and a liquid return pipeline of the cooling pipeline are respectively connected with the liquid inlet and the liquid outlet of each cooling channel through valves so as to form a plurality of cooling loops with controllable flow velocity. A heat exchange system composed of a constant-power heating unit and a built-in cooling loop is integrated in each charging barrel unit connected in series in the axial direction, the flow speed of a cooling medium is adjusted through temperature feedback, heating and cooling are decoupled, the heating temperature of each charging barrel unit is independently adjusted in the mode that the flow speed of the cooling medium is changed, and the heating efficiency is improved. And dynamic regulation and control on the extrusion temperature of the molten material are realized.
Owner:WUHU HAODELI ENVIRONMENTAL PROTECTION TECH CO LTD

Heat-resistant stable recombinant humanized V-type collagen and preparation method thereof

The embodiment of the invention discloses heat-resistant stable recombinant humanized V-type collagen and a preparation method thereof, relates to the technical field of recombinant protein, and aims to solve the technical problem that existing collagen is difficult to meet application requirements. The preparation method of the heat-resistant and stable recombinant humanized V-type collagen comprises the following steps: respectively obtaining recombinant collagen with gene sequences as shown in SEQ ID No.2, SEQ ID No.4 and SEQ ID No.6, and respectively inserting the recombinant collagen into pPIC9K plasmids to obtain corresponding recombinant plasmids; the recombinant plasmids comprise a recombinant plasmid pPIC9K-ColV alpha 1-1, a recombinant plasmid pPIC9K-ColV alpha 1-2 and a recombinant plasmid pPIC9K-ColV alpha 1-4, and the recombinant plasmid pPIC9K-ColV alpha 1-1, the recombinant plasmid pPIC9K-ColV alpha 1-2 and the The recombinant plasmid is sequentially subjected to electrotransformation treatment, screening treatment, identification treatment and purification treatment, and the recombinant V-type collagen alpha1 is obtained; the recombinant V type collagen alpha1 comprises a recombinant V type collagen alpha1-1, a recombinant V type collagen alpha1-2 and a recombinant V type collagen alpha1-4.
Owner:INTERFIELD (CHENGDU) BIOLOGICAL PROD CO LTD

Heat-stabilized, flame retardant polymer composition

A polymer composition that comprises from about 20 wt.% to about 70 wt.% of a polymer matrix that includes a polyamide; from about 10 wt.% to about 50 wt.% of inorganic fibers; from about 5 wt.% to about 30 wt.% of a flame retardant system that includes an organophosphorous compound; and from about 0.1 wt.% to about 5 wt.% of a stabilizer system that includes a heat stabilizer is provided. The heat stabilizer includes a copper compound. The polymer composition exhibits an initial tensile strength and an aged tensile strength after exposure to temperature of 200°C for 1,000 hours. The ratio of the aged tensile strength to the initial tensile strength is about 0.5 or more.
Owner:CELANESE INTERNATIONAL CORP

Alkyl-bridged tin-based heat stabilizers for halogenated resins, their synthesis and use

The present invention relates to stabilizer compositions for halogen-containing polymers. It has recently been discovered that tin-based heat stabilizers with a bridging alkyl group between two tin centers are effective stabilizers while effectively doubling the molecular weight of the corresponding non-alkyl-bridged stabilizers. Ongoing testing is expected to confirm that the alkyl-bridged stabilizers are much less volatile, resulting in greater retention of the stabilizer in the final article.
Owner:PMC ORGANOMETALLIX INC

Full-bio-based high-performance polyhydroxyalkanoate (PHA) lamination master batch as well as preparation method and application thereof

The invention relates to the technical field of biodegradable high polymer materials, in particular to a full-bio-based high-performance polyhydroxyalkanoate (PHA) lamination master batch, a preparation method of the full-bio-based high-performance PHA lamination master batch and application of the full-bio-based high-performance PHA lamination master batch in preparation of lamination paper products. The full-bio-based high-performance polyhydroxyalkanoate (PHA) lamination master batch is characterized by comprising the following raw material components in parts by weight: 70-100 parts of a mixture of crystalline or semi-crystalline PHA and high-fluidity PHA; 0.1-1 part of a heat stabilizer; 0.1 to 2 parts of a nucleating agent; 0.1 to 1 part of a chain extender; 0.1 to 1 part of a melt reinforcing agent; 0.05 to 0.5 part of an antioxidant; and 0.05 to 0.5 part of a lubricant. According to the present invention, the crystal type / semi-crystal type PHA and the high fluidity PHA are combined according to the specific ratio, and a variety of functional auxiliary agents are supplemented so as to form the synergistic effect; the crystalline PHA provides strength and rigidity, and the high-fluidity PHA is used as a plasticizer and a flexibilizer, so that the processing window is effectively widened, and the melt strength and toughness are improved.
Owner:HEFEI HENGXIN ENVIRONMENTAL SCI & TECH CO LTD

Methods and systems for thermally stabilizing pharmaceutical formulations containing proteins and monoclonal antibodies

A method and system for the thermal stabilization of pharmaceutical formulations containing proteins and monoclonal antibodies is disclosed. The disclosed method of rapid room temperature aerosol dehydration (RTAD) provides a scalable system for the continuous dehydration of liquid pharmaceutical formulations and biopharmaceutical formulations that provides thermal stabilization of biopharmaceuticals by converting the liquid pharmaceuticals into a powder form, enabling them to be transported, stored and handled at room temperature. The disclosed method can generate a spray / aerosol with droplet sizes that are 100 times smaller (0.2-20 μm) than existing spray drying techniques and dehydrates without the application of heat, mitigating the risk of damage to heat labile biologies and providing a significant reduction in energy requirements. The technology has demonstrated that the system is superior to conventional spray drying and freeze drying in terms of energy consumption, bioactivity, scalability, powder solubility, reduction of protein aggregation, particle size and size uniformity, and the high quality of the resulting inhalable and reconstitutable biopharmaceuticals.
Owner:THE TRUSTEES OF PRINCETON UNIV

Thermal stability KGF-2 based on dynamic disulfide bond introduced by AI and generation method and device thereof

PendingCN120818036ASenses disorderPeptide/protein ingredientsAspartic acid residueDisulfide bonding
The invention relates to a thermal-stable KGF-2 derivative with dynamic disulfide bond introduced based on artificial intelligence, and a generation method, device and application of the thermal-stable KGF-2 derivative. According to the thermally stable KGF-2 derivative, a cysteine residue at the 106th site of wild type KGF-2 is mutated into an aspartic acid residue, a cysteine residue at the 150th site of the wild type KGF-2 is mutated into a valine residue so as to prevent disulfide bond mismatch, and a histidine residue at the 171st site and a glutamine residue at the 190th site of the wild type KGF-2 are mutated into cysteine residues so as to form a disulfide bond; and removing amino acid residues from the 2nd site to the 68th site. The amino acid sequence of the heat-stable KGF-2 derivative is as shown in SEQ ID NO: 4. According to the scheme provided by the invention, the dynamic disulfide bond can be introduced on the basis of an artificial intelligence technology and a computational structural biology platform, the thermostable KGF-2 derivative is generated on the premise of not influencing the molecular structure and function of the KGF-2 protein, and the problem of mismatching of the disulfide bond can be prevented while the protein molecular stability is improved by introducing the disulfide bond.
Owner:SHENZHEN NEWROSETTA BIOSCIENCES CO LTD

Cat polycystic kidney gene mutation detection kit based on CRISPR-Cas12a

The invention relates to the technical field of biological detection, in particular to a cat polycystic kidney gene mutation detection kit based on CRI SPR-Cas12a. The kit comprises a freeze-dried CRI SPR reaction ball which is composed of a Cas12a enzyme, a targeted PKD1 gene c.10063Cgt, a CRI SPR gene c.10063Cgt, a CRI SPR gene c.10063Cgt and a CRI SPR gene c.10063Cgt. The kit is formed by premixing and freeze-drying gRNA of a T mutation site and a fluorescence labeling-quenching group reporter probe. The normal-temperature lysis solution is prepared from protease K, a TritonX-100 surfactant and sodium chloride; the chromogenic test strip is formed by arranging two detection lines, namely a T1 line and a T2 line, on a nitrocellulose membrane; and a quality control line C. The CRI SPR reaction ball is freeze-dried to integrate Cas12a enzyme, PAM simulates gRNA and double reporter probes, so that the normal-temperature long-acting stability of key components is realized; a normal-temperature lysis solution is fused with thermal stable protease K and a nuclease inhibition technology, sample DNA is directly released in a short time, degradation is blocked, and the step of centrifugal purification is eliminated.
Owner:SUZHOU JIDITAI BIOTECHNOLOGY CO LTD

Method and system for thermal stabilization of pharmaceutical formulations containing enveloped and nonenveloped virus particles

Disclosed are a method and system for thermal stabilization of pharmaceutical formulations containing enveloped and nonenveloped viruses. The disclosed method of Rapid Room Temperature Aerosol Dehydration (RTAD) provides a scalable system for continuous dehydration of liquid pharmaceutical and biopharmaceutical formulations that provides thermal stabilization of biological drugs by converting liquid drugs into powder form, enabling their transportation, storage and handling at room temperature. The disclosed process can generate sprays / aerosols with droplets that are 100x smaller (0.2-20 μm) than existing spray drying technologies and perform dehydration, without applying heat, which mitigates the risk of damage of thermolabile biologicals and provides a significant reduction in energy requirements. The technology has demonstrated superiority of the system over traditional spray drying and freeze drying with respect to energy consumption, biological activity, scalability, powder solubility, particle size and size uniformity, and high-quality of produced inhalable and reconstitutable biologic formulations.
Owner:THE TRUSTEES OF PRINCETON UNIV +1

Feeding device for PVC heat stabilizer production

The utility model provides a feeding device for PVC (polyvinyl chloride) heat stabilizer production, which relates to the technical field of PVC heat stabilizer production and comprises a mixing barrel, the top and the bottom of the mixing barrel are closed, a tray is fixed at the top of the mixing barrel, a support tray is rotatably arranged at the bottom of the mixing barrel, and the support tray is fixed on the mixing barrel. According to the material mixing device, materials needing to be mixed and configured are placed in the material mixing barrel to be stirred and mixed, after the materials are stirred and mixed, the supporting disc is driven to rotate through rotation of the rotating shaft, and when the supporting disc rotates and passes through the discharging hole, the supporting disc is driven to rotate, so that the materials are uniformly mixed. According to the intermittent material taking device, materials stirred in the material mixing barrel are stored through the storage pipe and then conveyed to the bending part, and the materials in the storage pipe are discharged under the action of the bending part, so that the intermittent material taking function can be achieved, meanwhile, the situation that the materials need to be reconfigured after one-time operation and each-time feeding are finished is avoided, and the overall production efficiency is higher.
Owner:HUANGSHAN JIABAO NEW MATERIAL TECH CO LTD

Modified stabilizer aid and preparation method thereof

The invention belongs to the technical field of stabilizer preparation, and particularly relates to a modified stabilizer additive and a preparation method thereof. The preparation method comprises the following steps: preparing a nitrogen-containing compound, namely 1-(4-cyclohexylphenyl)-3-(5-methyl-1H-indole-3-yl) urea-zinc, and proportioning calcium stearate and the 1-(4-cyclohexylphenyl)-3-(5-methyl-1H-indole-3-yl) urea-zinc according to a mass ratio of 1: 2, so as to obtain the modified stabilizer. By adding the stabilizer disclosed by the invention, the heat stability of PVC can be remarkably improved. In addition, in a tensile test, a PVC sample added with the stabilizer disclosed by the invention has relatively high tensile strength (the highest tensile strength can reach 20.68 MPa) and elongation at break (the highest elongation at break can reach 394%). The static thermal stabilization time of a PVC sample added with the stabilizer disclosed by the invention in a Congo experiment is 42 minutes longer than that of a blank sample. Therefore, the stabilizer disclosed by the invention can become a very promising potential raw material of the PVC heat stabilizer.
Owner:SHANDONG YUANTAI POLYMER MATERIAL CO LTD

Environment-friendly double-effect dyeing and finishing process for cellulosic fiber fabric

The invention relates to an environment-friendly double-effect dyeing and finishing process for a cellulosic fiber fabric, and relates to the technical field of textile dyeing and finishing, and the process comprises the step of adding a fabric, water, a biological enzyme, a dye and a multifunctional microcapsule into a treatment bath at one time. Enzyme treatment is firstly carried out at low temperature, then heating is carried out, the temperature is utilized to trigger the microcapsule to release the alkaline agent in the inner core, the dye bath is automatically changed from acidity to alkalinity, and thus color fixation is continuously completed in the same bath. The microcapsule is characterized in that an inner core is a compound of an alkaline agent and a buffering agent, stable rising of the pH value is ensured, and the leveling property is improved; the temperature-sensitive phase-change polymer shell layer stabilizes the temperature through phase-change heat absorption during heating, dye hydrolysis is reduced, and the temperature-sensitive phase-change polymer shell layer serves as a dispersing agent after being dissolved to improve the soaping effect and the color fastness. The two core steps of biological enzyme treatment and reactive dye fixation with repellent chemical environments are integrated in the same treatment bath, so that the production cycle is greatly shortened.
Owner:HANGZHOU TIANRUI DYEING PRINTING

Antibacterial and mildew-proof PVC wallboard material and preparation method thereof

PendingCN122278081ACyclodextrinPhytic acid
This invention belongs to the technical field of PVC wall panel materials, specifically an antibacterial and mildew-resistant PVC wall panel material and its preparation method, comprising the following components: polyvinyl chloride resin, an antibacterial and mildew-resistant slow-release complex, a calcium-magnesium composite heat stabilizer, an environmentally friendly plasticizer, an acrylate processing aid, a composite lubricant, and fillers. This invention utilizes a composite coating system constructed with a rhamnose lipase-modified nano-zinc oxide amphiphilic coating layer as the inner layer and a phytic acid-modified β-cyclodextrin and trisodium citrate synergistic adsorption layer as the outer layer. This system encapsulates nano-zinc oxide within the PVC matrix, delaying the risk of zinc ion leaching from landfills and inhibiting the activity of key extracellular enzymes in the soil. Simultaneously, the heat stabilizer, plasticizer, and processing components help maintain the matrix's density, indirectly enhancing physical barrier properties and achieving low ecological impact throughout the wall panel's life cycle.
Owner:BARANA INT