7 results about "Nitrobenzoates" patented technology

This invention relates to a taraxasterol nitrobenzoate derivative in the field of medicinal chemistry, with the following structural formula: Compound B is obtained by reacting taraxasterol 1 with 4-nitrophthalic anhydride in a suitable alkaline catalyst and organic solvent. This synthetic route offers high yield and is easy to implement. Activity tests demonstrate that the taraxasterol nitrobenzoate derivative shown as B, designed and synthesized in this invention, is a suitable antitumor drug candidate, particularly as a candidate drug for lung cancer.

The present invention belongs to the field of biological preparation technology and specifically relates to the use of (Z)-[amino(pyridin-2-yl)methylene]amino-2-nitrobenzoate in the preparation of products for inhibiting influenza viruses. The present invention is the first to discover that (Z)-[amino(pyridin-2-yl)methylene]amino-2-nitrobenzoate has a significant inhibitory effect on influenza A virus at the cellular level. The inhibition efficiency reaches 95% without affecting cell activity, which makes it have great potential for clinical application.

The present invention relates to a novel nitration process of 2-chloro-4-fluorobenzoic acid or alkyl 2-chloro-4-fluorobenzoate, using oleum and nitric acid, to obtain 2-chloro-4-fluoro-5-nitrobenzoic acid or alkyl 2-chloro-4-fluoro-5-nitrobenzoates; purifying the crude reaction product; and recovering 2-chloro-4-fluoro-5-nitrobenzoic acid or alkyl 2-chloro-4-fluoro-5-nitrobenzoates in an essentially pure form, which can be used in the synthesis of the herbicide saflufenacil.

The invention relates to a preparation method of a lenalidomide compound. The process comprises the following steps: in a N-methyl pyrrolidone or acetonitrile solvent, by using triethylamine or DIPEA (Diisopropylethylamine) as an acid binding agent, enabling 2-bromomethyl-3-nitrobenzoate to react with alpha-amino glutarimide hydrochloride, so as to obtain 3-(4-nitro-1-oxo-1, 3-dihydroisoindole-2-yl)-piperidine-2, 6-diketone; in the presence of hydrazine hydrate and Pd / C, nitryl of 3-(4-nitro-1-oxo-1, 3-dihydroisoindole-2-yl)-piperidine-2, 6-diketone is reduced, and lenalidomide is obtained. The process is easy and convenient to operate and mild in reaction condition, the purity of the obtained lenalidomide reaches 99.9% or above, the impurity content is extremely low, and the method is suitable for industrial production. The invention also provides high-purity lenalidomide prepared on the basis of the process and an industrial production method of the lenalidomide.

The invention discloses a 4-nitrobenzoate compound as well as preparation and application thereof. The method comprises the following steps: taking aniline as an initial raw material, obtaining a phenyl diazonium salt intermediate through diazotization of a sodium nitrite / hydrochloric acid system, further reacting the phenyl diazonium salt intermediate with biphenyl-2-phenol to obtain a 5-(phenylazo)-[1, 1 '-biphenyl]-2-phenol intermediate, and reacting the 5-(phenylazo)-[1, 1'-biphenyl]-2-phenol intermediate with p-nitrobenzoyl halide under the combined action of a catalyst and alkali to obtain the 5-(phenylazo)-[1, 1 '-biphenyl]-2-phenol. The invention relates to 1, 1 '-biphenyl]-2-yl 4-nitrobenzoate. The 5-(phenylazo)-[1, 1 '-biphenyl]-2-yl 4-nitrobenzoate can be subjected to catalytic hydrogenation reduction in the presence of a nickel catalyst to obtain a polyimide monomer diamine compound 5-amino-[1, 1'-biphenyl]-2-yl 4-aminobenzoate. The method is simple and convenient to operate, mild in process condition, small in pollution, high in synthesis efficiency, good in product purity and suitable for industrial large-scale production.

The invention belongs to the technical field of chemical engineering, and particularly relates to a method and a device for circularly preparing a 3-methyl-2-nitrobenzoate compound. The preparation method of the 3-methyl-2-nitrobenzoate compound comprises the following steps: (1) adding 3-methyl-2-nitrobenzoic acid and saturated fatty alcohol into a preparation kettle for dissolving, and adding an obtained homogeneous mixed solution and a catalyst into a mixing storage tank; and (2) opening a circulating pump to enable the material to circularly flow and dehydrate in a device consisting of the mixing storage tank, the filter and the membrane equipment until the flow speed is stable. And (3) opening the preheater to heat the reaction liquid in the mixing storage tank under the condition that the reaction liquid circularly flows, performing esterification reaction, performing in-situ water separation on the permeation side of the membrane equipment in the reaction process, and finally circulating the esterification product into the mixing storage tank. According to the method provided by the invention, the alcohol-acid ratio in the esterification process is reduced, the reaction period is greatly shortened, the consumption of electric power, steam and circulating cooling water is saved, and the operation cost is reduced.

The present invention relates to a continuous flow production process for synthesizing candesartan cilexetil intermediates, and belongs to the technical field of fine chemicals. Specifically, a process for continuously preparing 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate using a microchannel reactor is provided, comprising: allowing 2-(chlorocarbonyl)-3-nitrobenzoate and sodium azide to stay in a first reaction module for reaction; then the reaction solution and water simultaneously enter a continuous separator for separation; the separated organic layer reacts with tert-butyl alcohol in a second reaction module to obtain a target product. The method provided by the present invention is safe, simple to operate, efficient, and easy to mass produce.