3 results about "Nitrobenzoates" patented technology

This invention relates to a taraxasterol nitrobenzoate derivative in the field of medicinal chemistry, with the following structural formula: Compound B is obtained by reacting taraxasterol 1 with 4-nitrophthalic anhydride in a suitable alkaline catalyst and organic solvent. This synthetic route offers high yield and is easy to implement. Activity tests demonstrate that the taraxasterol nitrobenzoate derivative shown as B, designed and synthesized in this invention, is a suitable antitumor drug candidate, particularly as a candidate drug for lung cancer.

The present invention relates to a novel nitration process of 2-chloro-4-fluorobenzoic acid or alkyl 2-chloro-4-fluorobenzoate, using oleum and nitric acid, to obtain 2-chloro-4-fluoro-5-nitrobenzoic acid or alkyl 2-chloro-4-fluoro-5-nitrobenzoates; purifying the crude reaction product; and recovering 2-chloro-4-fluoro-5-nitrobenzoic acid or alkyl 2-chloro-4-fluoro-5-nitrobenzoates in an essentially pure form, which can be used in the synthesis of the herbicide saflufenacil.

The invention discloses a 4-nitrobenzoate compound as well as preparation and application thereof. The method comprises the following steps: taking aniline as an initial raw material, obtaining a phenyl diazonium salt intermediate through diazotization of a sodium nitrite / hydrochloric acid system, further reacting the phenyl diazonium salt intermediate with biphenyl-2-phenol to obtain a 5-(phenylazo)-[1, 1 '-biphenyl]-2-phenol intermediate, and reacting the 5-(phenylazo)-[1, 1'-biphenyl]-2-phenol intermediate with p-nitrobenzoyl halide under the combined action of a catalyst and alkali to obtain the 5-(phenylazo)-[1, 1 '-biphenyl]-2-phenol. The invention relates to 1, 1 '-biphenyl]-2-yl 4-nitrobenzoate. The 5-(phenylazo)-[1, 1 '-biphenyl]-2-yl 4-nitrobenzoate can be subjected to catalytic hydrogenation reduction in the presence of a nickel catalyst to obtain a polyimide monomer diamine compound 5-amino-[1, 1'-biphenyl]-2-yl 4-aminobenzoate. The method is simple and convenient to operate, mild in process condition, small in pollution, high in synthesis efficiency, good in product purity and suitable for industrial large-scale production.