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Benzoic acid or benzoic acid esters substituted with one or more nitro groups.
Taraxasterol nitrobenzoate derivatives and their anti-tumor applications
Pending
CN122127386A
Organic active ingredients
Steroids
Benzoic acid
Structural formula
This invention relates to a taraxasterol nitrobenzoate derivative in the field of
medicinal chemistry
, with the following
structural formula
: Compound B is obtained by reacting taraxasterol 1 with 4-nitrophthalic anhydride in a suitable
alkaline catalyst
and
organic solvent
. This synthetic
route
offers high yield and is easy to implement. Activity tests demonstrate that the taraxasterol nitrobenzoate derivative shown as B, designed and synthesized in this invention, is a suitable antitumor
drug
candidate, particularly as a candidate
drug
for
lung
cancer
.
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Owner:
ZUNYI MEDICAL UNIVERSITY
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