4 results about "Polyglycerol monostearate" patented technology

This invention belongs to the field of nanoparticle hydrogel scaffold technology, providing an MMP-responsive nanoparticle hydrogel scaffold and its application in the treatment of fibrous bone dysplasia. The nanoparticle hydrogel scaffold is prepared by cross-linking and curing triglyceride monostearate nanoparticles, 3-aminophenylboronic acid-modified hyaluronic acid, and dopamine-modified hyaluronic acid. This invention is based on the first discovery that the concentration of matrix metalloproteinases (MMPs) around fibrous bone dysplasia lesions is a biomarker reflecting the "activity and treatment response of fibrous bone dysplasia lesions," and based on this discovery, provides an MMP-responsive nanoparticle hydrogel scaffold and its application in the treatment of fibrous bone dysplasia. This nanoparticle hydrogel scaffold can achieve perilesional drug delivery and sustained MMP-responsive drug release through injection, thereby providing a local treatment strategy for fibrous bone dysplasia.

The present application belongs to the technical field of polyamide fiber preparation, and particularly relates to a polyamide spinning oil, a preparation method thereof and polyamide fiber. The polyamide spinning oil comprises the following raw material components in parts by weight: polyethylene glycol sorbitol hexaoleate 15-25 parts, polyethylene glycol 15-hydroxystearate 10-25 parts, triethanolamine di(octadecanoic acid) ester 10-20 parts, alkyl phenol polyoxyethylene quaternary ammonium salt 5-10 parts, chitosan quaternary ammonium salt 5-10 parts, tri-glycerol monostearate 20-30 parts, 2(3)-tert-butyl-4-hydroxyanisole 2-20 parts, anti-phenolic yellowing agent APY 2-5 parts, penetrant JFC 3-6 parts and bis(2,6-diisopropylphenyl)carbodiimide 1-5 parts. The polyamide spinning oil of the present application is designed rationally, which significantly improves the smoothness, flexibility, bundling, anti-static property, yellowing resistance and other properties of the polyamide spinning fiber, and also has the synergistic effects of antibacterial, antioxidant degradation and hydrolysis resistance, thereby improving the product performance of the polyamide fiber.

The invention discloses a low-temperature-resistant and impact-resistant polypropylene foamed sheet and a formula thereof, and relates to the technical field of foamed sheets, the low-temperature-resistant and impact-resistant polypropylene foamed sheet comprises the following raw materials: modified homo-polypropylene, modified zinc stearate, a foaming agent and a filler; according to the invention, the modified homo-polypropylene is added, so that the low-temperature impact resistance of the material can be improved, the foaming nucleation capability is optimized, the foam structure stability is improved, and the weather resistance and aging resistance of long-term low-temperature outdoor use can be remarkably enhanced; modified zinc stearate is added, the modified zinc stearate is used as a basis, polyglycerol monostearate and modified gas-phase nano silicon dioxide are used for carrying out difunctional modification to obtain a multifunctional auxiliary agent, and the multifunctional auxiliary agent can cooperate with zinc oxide to activate the ADC foaming agent and reduce the decomposition temperature of the foaming agent so as to broaden a processing temperature window; the system lubricity and melt flowability can be improved, and the problems of equipment mold sticking and material agglomeration are reduced.

The invention discloses an enzyme response hydrogel for treating inflammatory bowel disease as well as a preparation method and application thereof, and the enzyme response hydrogel comprises the following components in percentage by weight: 13-18% of an effective part of pediatric stolonifera, 75-85% of an enzyme response gel matrix, 0.5-1% of purified water, 2-4% of a transdermal absorption enhancer, 0.5-1% of a solubilizer and 0-0.1% of a preservative. The enzyme response gel matrix is tripolyglycerol monostearate, the transdermal absorption enhancer is at least one of azone, oleic acid and propylene glycol, the solubilizer is at least one of tween-80, propylene glycol, polyethylene glycol and span, and the preservative is at least one of ethylparaben, phenoxyethanol and hexanediol. The enzyme response hydrogel prepared by the invention can release drugs in the presence of a specific enzyme, and due to the characteristic, the enzyme response hydrogel can act on diseased regions more accurately in treatment of inflammatory bowel diseases, so that the side effects of the whole body are reduced, and the safety and effectiveness of treatment are improved.