33results about How to "Avoid lowering production costs" patented technology

The invention provides an S-pantoprazole sodium composite for injection, which is prepared through a method comprising the following steps of: (1) preparing liquid medicine: selecting S-pantoprazole sodium and edetic acid or edetate as raw materials, wherein the weight ratio of the S-pantoprazole sodium and the edetic acid or the edetate is 1:0.01-0.1; weighing a right amount of the raw materials, placing into a preparation tank, adding water for the injection till the weight of a solution is 11.82-118.2 times more than that of the S-pantoprazole sodium, stirring for dissolution, uniformly mixing, and regulating the pH value of the solution at 10.0-12.5; (2) finishing active carbon; (3) absorbing; (4) carrying out aseptic filtration and split charging; and (5) carrying out vacuum freeze drying so as to obtain the S-pantoprazole sodium composite for the injection. The S-pantoprazole sodium composite for the injection and the preparation method thereof can both ensure that product heat sources, visible foreign matters and insoluble particles meet the requirements of injections for the injections, i.e. S-pantoprazole sodium preparing liquid medicine which has higher pH.

The invention discloses a method for one-pot liquid phase synthesis of quinoline with formula (II) and derivative thereof. The method takes aromatic nitro-compound with formula (I) and fatty alcohol as the materials to react under the action of activator to prepare the quinoline or the derivative thereof, wherein the fatty alcohol is one of the C2-C5 fatty alcohols or the mixture of methanol and one of the C2-C5 fatty alcohols; and the activator is alumina supported palladium-copper solid activator. Through the method, the activator is easy to separate with the product and can be used repeatedly; the activator is easy to prepare and the noble metals are easy to recover, thus reducing the production cost; meanwhile, the product has good quality and high yield.

The invention provides a zoledronic acid composition for injection. The zoledronic acid composition for injection is prepared by the following steps of: 1) preparing medicinal liquid, namely selecting zoledronic acid and trisodium citrate as raw materials according to the weight ratio of the zoledronic acid to the trisodium citrate of 1:0.5-2, weighing a proper amount of the raw materials and placing the raw materials into a preparation tank, adding water for injection until the weight of the solution is 250 to 1,250 times that of the zoledronic acid, stirring the solution to dissolve the rawmaterials and mixing the raw materials uniformly and adjusting the pH value of the solution to be 4.0 to 6.0; 2) performing active carbon finishing; 3) performing adsorption; 4) performing aseptic filtration and subpackaging; and 5) performing vacuum freeze drying to obtain the zoledronic acid composition for injection. By the zoledronic acid composition for injection and the preparation method thereof, for injection of which the clarity is influenced by active carbon greatly, such as the zoledronic acid and the like, the heat source, the clarity and insoluble particles of the product can meet the requirements of the injection.

The invention provides a high specific gravity tungsten alloy material and a preparation method thereof. The preparation method includes: 1) ball milling tungsten powder to obtain modified tungsten powder; 2) mixing nickel powder and iron powder and then ball milling to obtain nanocrystalline nickel-iron solid solution; 3) preparing modified tungsten powder and nano After the crystalline nickel-iron solid solution is mixed according to the mass ratio of 93:7, it is pressed into a billet; 4) the billet is liquid-phase sintered to make a sintered billet with a relative density of 93.9-99.8%; 5) the ultrafine graphite powder and The nano-silica powder is (60-90) according to the mass ratio: (20-40) and ball milled after mixing the powder, pressed to a relative density of 80-90% and made into a lubricating medium; 6) placing the sintered blank in a lubricating medium Hot hydrostatic extrusion is carried out in the medium, and the sintered billet after hot hydrostatic extrusion is heat treated to obtain a high specific gravity tungsten alloy material. The high specific gravity tungsten alloy material prepared by this method can still maintain good elongation when the strength is greatly improved.

The invention provides an Esomeprazole sodium composition used for injection and its preparation method, the Esomeprazole sodium composition is prepared by the following steps: 1) liquid preparation: selecting esomeprazole sodium and ethylenediamine tetraacetic acid or ethylenediamine tetraacetic acid salt as raw materials, wherein the weight ratio of esomeprazole sodium to ethylenediamine tetraacetic acid or ethylenediamine tetraacetic acid salt is 1:0.01-0.1, weighting a proper amount of raw materials into a preparation tank, and adding water for injection to the weight of 23.47-234.7 timesof esomeprazole sodium, stirring and uniformly mixing the solution, adjusting the pH value of 10.0-12.5; 2) activated carbon finishing; 3) adsorbing; 4) sterile filtrating and split charging; 5) vacuum freeze-drying to obtain the esomeprazole sodium composition used for injection. The esomeprazole sodium composition used for injection and the preparation method are capable of ensuring the heat source, visible foreign matter and insoluble particulate to accord with the requirements of the injection for the injection preparations such as esomeprazole sodium preparation liquid with high pH value.

The invention provides a synthetic method of A-nor-3,5-cracking-androstane-5-ketone-3,17 beta-diacid. The method comprises the following steps of: adding hydrogen peroxide and acid into 3-carbonyl-4-androstene-17-thiolic acid in a solvent in the presence of a metal catalyst for reacting; adding a reducing agent after reacting; and collecting A-nor-3,5-cracking-androstane-5-ketone-3,17 beta-diacidserving as a target product from a reaction product. By adopting the method, a high-purity product can be obtained at high yield and high selectivity. The used method is simple, safe and environmentally-friendly. The reaction condition is mild, the reaction is relatively complete, and the purity is over 99 percent by simple purification. All reagents used in the entire reaction are readily-available, and meanwhile, the reaction yield is high, the reaction condition is mild, the solvent can be recycled, and industrial implementation is convenient.

The invention discloses a manufacturing method for a light emitting diode epitaxial wafer, which belongs to the technical field of semiconductors. The method comprises the steps that a substrate is provided; a low temperature buffer layer, a high temperature buffer layer, an N type gallium nitride layer, an active layer, an electron blocking layer and a P type gallium nitride layer successively grow on the substrate; the high temperature buffer layer comprises (n+1) gallium nitride layers and n aluminum gallium nitride layers, wherein n is a positive integer and (n+1) gallium nitride layers and n aluminum gallium nitride layers are alternately stacked; the growth temperature of (n+1) gallium nitride layers increases layer by layer along the growth direction of the light emitting diode epitaxial wafer; the growth rate of (n+1) gallium nitride layers accelerates layer by layer along the growth direction of the light emitting diode epitaxial wafer; and the aluminum component content in n aluminum gallium nitride layers increases layer by layer along the growth direction of the light emitting diode epitaxial wafer. According to the invention, the improvement of the growth temperature of the gallium nitride layers and the aluminum component content in the aluminum gallium nitride layers compensates for defects produced by the improvement of the growth rate; the growth cycle is reduced; and the production cost is reduced.

The invention relates to a method for manufacturing a tension screw type laminated iron core, which comprises the following steps: step 1, stacking of punching sheets of the iron core and installationof tension screws: axially applying pressure on the punching sheets of the iron core by sections, and after the punching sheets of the iron core are stacked and pressed, preliminarily tightening fastening elements of the tension screws of the iron core in the compressed state; step 2, compaction processing: performing compaction processing on the iron core that is preliminarily tightened; step 3,when the iron core is at room temperature, tightening the tightening screws of the iron core subjected to compaction processing again; and step 4, spot welding for fixation: performing spot welding on the tension screws and the fastening elements thereof, so that the iron is fixed as one piece. Through the newly-added compaction processing, and re-tightening and then spot welding after the compaction processing, the iron core is formed as one piece to avoid the loosing of the laminated iron core loose, the laminated iron core is not easy to produce distortion and deformation, and ultimately the electrical performance of the motor is ensured and the working efficiency is improved.