The invention discloses an anti-fouling high-throughput polysulfone composite membrane. The anti-fouling high-throughput polysulfone composite membrane is prepared from, by weight, 50-80 parts of caprolactam-modified polysulfone, 10-20 parts of sulphonated polysulfone, 2-15 parts of polyvinylidene fluoride, 5-15 parts of polydiphenylmethylene acrylic polyurethane, 1-5 parts of polydiphenylmethylene vinyl polyurethane, 1-3 parts of perfluorinated sulfonic acid resin, 35-80 parts of a solvent, 1-4 parts of polyaniline nanofibers, 1-2 parts of nanometer zirconia, 0.1-0.5 part of nanometer lanthanum oxide, 1-2 parts of nanometer titanium dioxide, 0.2-1.5 parts of a modified boron nitride silane coupling agent, 0.3-1.5 parts of cellulose acetate, 0.5-3 parts of a polystyrene-alt-maleic anhydride copolymer and 0.5-3 parts of carboxyl betaine methacrylate. The anti-fouling high-throughput polysulfone composite membrane is good in thermal stability, excellent in weather resistance and anti-fouling performance and high in throughput.