The invention discloses a compound fertilizer generation system, and solves the problems of uneven particle, high moisture content, more returning charge and the like in the production and granulationprocesses of the existing compound fertilizer. In the technical scheme, the compound fertilizer generation system comprises a pretreatment system, a granulation system, a posttreatment system and a charge and returning charge system which are sequentially connected, the granulation system comprises a roller provided with a drive device, a discharge structure is connected to the rear end of the roller, a charge tube, an acid mixing tube, a tubular reactor and an ammonia spraying tube bundle are sequentially arranged at the front section of the roller from top to bottom, the acid mixing tube, the tubular reactor and the ammonia spraying tube bundle are respectively provided with a sprayer; the charge tube is connected with the charge and returning charge system, the tubular reactor is connected with an ammonia station, the pretreatment system and a sulfuric acid storage tank respectively; the acid mixing tube is connected with a tail gas treatment system and the sulfuric acid storage tank respectively; and the ammonia spraying tube bundle is connected with the ammonia station. The system is simple, saves energy and reduces consumption, the product strength is high, the returning rate is low, the production efficiency is high, the water solubility is good, and the compound fertilizer generation system is environmentally friendly.