The invention discloses a method for prevention and control of cadmium contamination of traditional Chinese medicine rhizoma coptidis. The method includes steps: (1) performing topdressing from September to October in the current year of rhizoma coptidis planting and in May in the second, third, fourth and fifth years, and after transplanting, performing topdressing once in autumn (September-October) in the second, third and fourth year, wherein topdressing is carried out for eight times to promote growth and activity of rhizoma coptidis and lays a foundation for prevention and control of cadmium absorption; then, after topdressing in autumn (September-October) in the second, third and fourth year after transplanting in the step (1), performing earth-up operation by adopting a cadmium blocking agent, wherein a spraying quantity of the cadmium blocking agent is 75-100Kg / mu, chelation of the cadmium blocking agent with cadmium in soil is realized, cadium absorption of rhizoma coptidis isreduced, stress resistance of rhizoma coptidis is improved, the self-protection performance of rhizoma coptidis is improved, plasma membrane damages of roots and leaves under cadmium stress are reduced, antioxidant enzyme activity of the leaves under cadmium stress is improved, the antitoxic performance of rhizoma coptidis is improved, system immunity is enhanced, cadmium accumulation is inhibited, and prevention and control of cadmium contamination are realized.