37results about How to "Reduce malondialdehyde (MDA) content" patented technology

The present invention belongs to the field of medicinal chemistry, and particularly relates to a bicyclol-based derivative and a pharmaceutically acceptable salt thereof, a preparation method of the bicyclol-based derivative, and applications of the bicyclol-based derivative in preparation of drugs for prevention and/or treatment of liver diseases and the like. The formula I is defined in the specification.

The invention discloses a pharmaceutical composition with antioxidanting and aging-delaying function and preparation method thereof. The pharmaceutical composition is made from rhodiola rosea, tocopherol and grape seed extract (proanthocyanidins content >=95%) according to a certain weight proportion; and it can be made into any common oral taken preparation form. The traditional Chinese medicine composition in the invention achieves the functions of antioxidanting and aging-delaying.

The invention discloses a pharmaceutical composition with antioxidanting and aging-delaying function and preparation method thereof. The pharmaceutical composition is made from grape seed extract (proanthocyanidins content >=95%), raspberry and sea-buckthorn according to a certain weight proportion; and it can be made into any common oral taken preparation form. The pharmaceutical composition in the invention achieves the functions of antioxidanting and aging-delaying.

The invention discloses a leonurus artemisia extract, an application thereof to a fish feed, the fish feed and a preparation method of the fish feed. The problems that effective components of an existing leonurus artemisia extract for a fish feed additive are not definite, the extraction rate is not high, and the growth promotion effect of the existing leonurus artemisia extract in high-density breeding of freshwater fish is inapparent and needs to be further increased according to the action mechanism are solved. The leonurus artemisia extract is applied to a fish feed for the high-density breeding of the freshwater fish to be used as a growth promoting agent, so that the activity of lipases and amylases in intestinal tracts can be improved. The optimal addition quantity of the leonurus artemisia extract is 0.35-0.4%. The leonurus artemisia extract has the advantages of being good in leonurus artemisia extraction effects, good in growth promotion effects on fish during the high-density breeding of the freshwater fish and the like.

The present invention discloses five-element liver-tonifying decomposed porridge. The five-element liver-tonifying decomposed porridge is prepared by mixing and fermenting a fermentation extract and solid fermentation materials, and then mixing the materials with seasoning materials; the fermentation extract is prepared from the following raw materials: sedum aizoon, celery roots, dried tangerineor orange peels, radish seeds, manyflower solomonseal rhizome, white radish roots, stachys geobombycis, lotus leaves, Chinese wolfberry fruits, glossy privet fruits, mulberry leaves, Chinese cabbages,charred eucommia bark, licorice, fructus momordicae, bananas, apples, honey, rice wine koji, water and corn; the solid fermentation materials are composed of the following raw materials: Chinese yams, haws, sea buckthorn, barley, rice, wheat in Jianghuai region, peas and yeasts; and the seasoning materials are prepared from the following raw materials: soybeans and Chinese yams. The present invention also discloses a preparation method of the five-element liver-tonifying decomposed porridge. The five-element liver-tonifying decomposed porridge is prepared by low-temperature fermentation extraction and decomposition, contains various trace elements required by human body, is convenient for human body to absorb and utilize, and has functions of nourishing liver and protecting liver.

The invention discloses a medicine for treating lipopolysaccharide/D-aminogalactose (LPS/GalN) induced liver injury. The medicine for treating lipopolysaccharide/D-aminogalactose (LPS/GalN) induced liver injury is forsythiaside A. The forsythiaside A is capable of alleviating liver pathological injury induced by lipopolysaccharide/D-aminogalactose (LPS/GalN), reducing content of malonaldehyde (MDA) and serum ALT (Alanine Aminotransferase) and AST (Aspartate Amino Transferase) levels. In addition, the forsythiaside A is capable of inhibiting NF-chiB activation, serum TNF-alpha and liver TNF-alpha levels caused by LPS/GalN. In addition, the forsythiaside A is capable of increasing expression of Nrf2 and haem oxygenase 1. Results show that the protection function of the forsythiaside A on LPS/GalN induced liver injury is achieved by activating Nrf2 and inhibiting NF-chiB activation.

The invention discloses an acne removing and whitening skincare product and a preparation method thereof. The acne removing and whitening skincare product is prepared from the following components inpercentage by weight: 1 to 10 percent of a fructus chaenomelis extract, 2 to 8 percent of a flos lonicerae japonicae extract and 3 to 8 percent of tea tree oil. According to the acne removing and whitening skincare product and the preparation method thereof, the fructus chaenomelis extract is adopted, and active ingredients of fructus chaenomelis can be utilized to activate cells, remove free radicals, eliminate melanin of skin and reduce and remove acnes to make the skin white, beautiful and active; in addition, the flos lonicerae japonicae extract with the effects of whitening, rejuvenating,metabolism improvement, anti-inflammation, acne removing and the like is added and the tea tree oil are added to synergistically act with the fructus chaenomelis extract to achieve the synergistic effects of whitening and acne removing; under the synergistic effects of a plurality of traditional medicinal extracts, the product has the effects of obviously improving the skin, effectively removingacnes and acne marks and protecting the skin, and the effects are obviously better than those achieved by separate addition of one or more plant extracts.

The invention discloses a skincare product for whitening skin and resisting senility, which includes, by weight, 5-15 parts of pawpaw stem cell extract, 5-20 parts of peony extract, and 3-20 parts ofblueberry extract. In the invention, the pawpaw stem cell has excellent compatibility with human body and is easy to absorb by human body, so that the skincare product has excellent promotion effect to growth of skin cells, can accelerate metabolism of the cells, and enhance activity of skin cells; in addition, the blueberry extract liquid and peony extract liquid, which have effects of whiteningand activating skin and reducing oxygen free radicals, have synergistic effect with the pawpaw stem cell extract, so that the skincare product has synergistic effect of whitening skin and resisting senility. With cooperation of the traditional Chinese medicine extracts, the product can significantly improve skin texture and increase elasticity of skin, thus achieving the effect of whitening skin and resisting senility. The product can delay the aging progress of skin, wherein the effect is significantly higher than that of single addition of one or two components in the formula.

The invention discloses a health food capable of rapidly eliminating exercise-induced fatigue and improving sport performance for athletes, which comprises the following raw materials by weight: 300 parts of spirulina, 30-20 parts of bee pollen, 20-30 parts of black matrimony vine and 10-20 parts of American ginseng. The invention also discloses a preparation method of the health food. The health food takes spirulina as a main material with maximum amount, so that motor function can be completely increased, the blood lactic acid value is reduced, and the anoxic motion capability is increased; and the health food takes bee pollen and matrimony vine as auxiliary materials, the bee pollen mainly reduces the content of blood urea nitrogen, so that the aerobic exercises capability is enhanced, black matrimony vine can enlarge oxygen consumption and mainly enhance cardiac vessels function and rapidly alleviate fatigue; the American ginseng is added for enhancing the flavor of the above materials, and has promotion effect for reducing lactic acid and urea nitrogen and enhancing cardiac vessels function. The health food provided by the invention has the effects of minimizing lactic acid accumulation after motion, reducing urea nitrogen value after motion, rapidly eliminating exercise-induced fatigue, increasing motor function and improving sport performance for athletes.

The invention discloses traditional Chinese medicine health preserving tea with an auxiliary blood sugar reducing effect and a preparation method thereof. The traditional Chinese medicine health preserving tea is prepared from the following raw materials in parts by weight: 22 to 46 parts of radix astragali extracts, 20 to 38 parts of rhizoma polygonati extracts, 6 to 10 parts of herba dendrodii officinalis ultra-micro powder, 6 to 8 parts of herba potentillae discoloris extracts, 8 to 12 parts of fructus momordicae extracts, 1 to 4 parts of tea polysaccharide, 0.1 to 0.5 part of chromium-enriched yeast and 0.1 to 0.5 part of selenium-enriched yeast. The traditional Chinese medicine health preserving tea innovatively uses radix astragali, rhizoma polygonate, herba dendrodii officinalis, herba potentillae discoloris, fructus momordicae, the tea polysaccharide and mineral trace elements required by the human body to achieve the auxiliary blood sugar reducing effect through compatibility;and all medicine are combined for use to realize the functions of supplementing qi, promoting the production of body fluid, nourishing yin, moistening the lung, tonifying the spleen, nourishing the kidney and performing upper, middle and lower tri-jiao harmonization regulation, and jointly achieve the efficacies of tonifying qi, nourishing yin, clearing away heat and reducing the blood sugar in an auxiliary way.

The invention discloses a whitening anti-aging composition containing extract of dendrobium stem cells and a use thereof. The whitening anti-aging composition comprises, by weight, 1-3 parts of dendrobium stem cell extract, 10-20 parts of cordyceps militaris extract, 5-15 parts of papaya extract and 5-15 parts of Salvia miltiorrhiza flower/leaf/root extract. Through combination of the cordyceps militaris extract, papaya extract, Salvia miltiorrhiza flower/leaf/root extract and dendrobium stem cell extract, the whitening anti-aging composition has the synergistic effect of whitening skin and removing wrinkle. Through synergism of various types of extract, the whitening anti-aging composition can obviously improve the skin quality, improve the skin elasticity, improve the skin proliferativeability and reduce the skin aging process, has the effects obviously higher than those of one or two extract, is safe and has no irritation.

The invention discloses an NMN-containing composition capable of delaying senescence and preparation method and application thereof. The NMN-containing composition capable of delaying senescence disclosed by the invention is prepared by taking nicotinamide mononucleotide (NMN), malus micromalus fruit extract, pumpkin seed extract, wall-broken pine pollen, grape seed extract and blueberry extract as main materials. By adopting the raw materials with a good antioxidant function and a free radical scavenging function and optimizing the proportion of all components and the preparation method, thecomposition with a remarkable effect on delaying senescence is finally prepared, and the composition can enhance the antioxidant enzyme activity in serum and organs, improves the activity of an organism free radical scavenger, inhibits the growth of free radicals, reduces the lipid peroxidation reaction, and protects tissue from being attacked by an oxidant and the free radicals, and accordingly,the effect of delaying senescence is exerted.

The invention relates to application of a petal-free sonneratia caseolaris fruit in the preparation of a drug for preventing and treating chemical liver injury. The petal-free sonneratia caseolaris fruit has relatively good effects on the treatment of liver injury caused by carbon tetrachloride, acetaminophen, antitumor drug cis-platinum, alcohol and heavy metal lead and therefore can be used forpreparing the drug for preventing and treating relevant liver injury.

The invention discloses a pilose antler-containing anti-skin-aging emulsion and a preparation method thereof. The feed additive is prepared from the following raw materials in parts by weight. 25-25 parts of cornu cervi pantotrichum 45 parts of radix astragali and 5.5 parts to 5.5 parts of radix astragali 7.5 parts, 5.5 parts to 5.5 parts of polygonatum odoratum 7.5 parts, 5.5 parts to 5.5 parts of dried rehamnnia roots 7.5 parts, 5.5 parts to 5.5 parts of safflower carthamus 7.5 parts, the coenzyme Q10 hyaluronic acid nano-emulsion is prepared from 5.5 to 7.5 parts of Tianshan snow chrysanthemum, 10 parts of coenzyme Q10, 12 to 16 parts of hyaluronic acid, 12 to 16 parts of vitamin E, 40 to 50 parts of xanthan gum, 1 to 1.5 parts of ethylparaben, 1 to 1.5 parts of butyl paraben, 5 to 15 parts of rosemary and 866.5 to 807.5 parts of oil-in-water nano-emulsion. The invention also discloses the preparation method of the emulsion. After the emulsion is smeared on the skin, the moisture content of the skin is effectively increased, the content of hydroxyproline, hyaluronic acid, SOD and other components is increased, and the MDA content is reduced. The aging symptoms such as skin appearance becoming moist, relaxed and wrinkled are reduced or eliminated.

The invention relates to a method for extracting Actinidia kolomikta active polyphenol and application thereof. The method includes the following steps: (A): ethanol extraction (B) petroleum ether extraction; (C) n-butanol extraction; (D) silica gel column separation: dissolving the n-butanol extract obtained in step (C) in 75 g of methanol, separating with silica gel column, performing gradient elution with petroleum ether-ethyl acetate-methanol at an elution rate of 2-8 mL/min to obtain brownish-black extract; (E) Sephadex LH-20 column chromatography purification: dissolving the brownish-black extract in methanol, purifying with Sephadex LH-20 column chromatography, and performing gradient elution with CH2C12-methanol at an elution rate of 2-8 mL/min to obtain Actinidia kolomikta active polyphenol. The extraction method of the Actinidia kolomikta active polyphenol has extraction yield of 12.29%, and the obtained Actinidia kolomikta active polyphenol has purity of 95-99.9%, and has effect of resisting D-galactose induced mouse aging.