50results about How to "High industrial production value" patented technology

The invention discloses a preparation method of high-purity topiramate. The topiramate is obtained by using 2,3,4,5-bis-O-(1-methylethylene)-beta-D-pyran fructose chlorosulfonate as a raw material and tetrahydrofuran and acetonitrile as solvents, adding ammonia-source ammonium acetate and performing amination under a heating condition, wherein the purity of the topiramate is not lower than 99.5%. The preparation method is low in cost, easy and convenient to operate, safe and efficient, and is suitable for large-scale industrial production.

A preparation method of 2-amino-4,6-dimethoxypyrimidine, using malononitrile and methanol as raw materials, using one of toluene, xylene, chlorobenzene, and dichloroethane as a solvent, through hydrogen chloride The aeration reaction generates 1,3-dimethoxypropanediimine dihydrochloride without filtration and other post-treatment operations. Add a water-insoluble organic base dropwise to the reaction system to adjust the pH of the reaction system to 6-8, and then add The solid reaction of cyanamide generates 3-amino-3-methoxy-N-nitrile-2-propionamidine, and then the heating reaction generates 2-amino-4,6-dimethoxypyrimidine product. The invention utilizes a one-pot method to prepare 2-amino-4,6-dimethoxypyrimidine, the reaction conditions are mild, safe and environmentally friendly, the process operation is simplified, the amount of three wastes is small, and the total synthesis yield of the four-step reaction can reach 80%. Above, the product content can reach more than 99%, which is suitable for green industrial production.

The invention discloses a three-dimensional porous nanocarbon composite lithium manganate spherical positive electrode material and a preparation method thereof. The preparation method comprises the following steps of adsorbing Mn<2+> ions onto a carbonyl (-COH-) group in a microgel three-dimensional macromolecular network by adopting poly(acrylamide, acrylic acid) microgel spheres as a template; increasing the pH value of the poly(acrylamide, acrylic acid) microgel spheres so as to in-situ hydrolyze the Mn<2+> ions to generate Mn(OH)2 crystal nucleus, depositing the Mn(OH)2 crystal nucleus into a space formed by the three-dimensional macromolecular network to form nano composite polymer microspheres; placing the obtained nano composite polymer microspheres into a tubular furnace to be calcined at a high temperature in an inert gas atmosphere to prepare the three-dimensional porous nanocarbon composite lithium manganate spherical positive electrode material. The positive electrode material has the advantages of excellent high-temperature cycling performance, large multiplying power charging-discharging performance and the like, and can be widely applied to the production of a lithium battery.

The invention provides a sphingomonas with a preservation number of CGMCC No.12394; a method for cultivating a carotenoid-producing strain, its application in the production of carotenoids, and its use in the industrial production of astaxanthin in the application. In the sphingomonas producing nodoc xanthin of the present invention, the content of nodoc xanthin can reach 3.98±0.5 mg / g, accounting for 90% or more of the total pigment. The colorless phytoene-producing bacteria SP-Phy, the red lycopene-producing bacteria SP-Lyc, and the yellow zeaxanthin-producing bacteria SP-Zea selected and bred by the present invention are successively passed on for more than 5 generations respectively. The yields of lycopene, lycopene and zeaxanthin are stable, and the content can reach 3.7±0.5mg / g, 3.9±0.5mg / g, 4.0±0.5mg / g respectively, accounting for 90% and above of the total pigment; The produced zeaxanthin-producing strain SP-Zea introduced the ketolase gene and transformed it into an astaxanthin-producing strain SPZ-AST, with an astaxanthin content of 4.1±0.5 mg / g, accounting for 90% or more of the total pigment.