46 results about "Hydroxyacetates" patented technology

Disclosed is a process for the extractive recovery of a homogeneous ruthenium catalyst from the reaction product of the hydrogenation of glycolic acid, glycolate esters, and / or glycolic acid oligomers with an extractant comprising a hydrophobic solvent and an optional hydrophilic solvent. The ruthenium catalyst, which can include 1,1,1-tris(diaryl- or dialkylphosphinomethyl)alkane ligands, can be recovered from the hydrophobic extract phase by back extraction with a hydrophilic solvent and recycled to a process for the preparation of ethylene glycol by the hydrogenation of glycolic acid and glycolic acid derivatives.

A release layer paste used for producing a multilayer type electronic device and forming a release layer of a thickness of 0.05 to 0.1 μm, used in combination with an electrode layer paste including one or more solvents selected from limonene, dihydroterpinyl methyl ether, α-terpinyl acetate, terpinyl methyl ether, isobornyl acetate, caryophyllene, 1-dihydrocarvyl acetate, menthone, menthyl acetate, perillyl acetate, carvyl acetate, d-dihydrocarvyl acetate, and butyl carbitol acetate and a binder comprised of ethyl cellulose, including a ceramic powder, organic vehicle, plasticizer, and dispersion agent, the organic vehicle containing a binder having polyvinyl acetal as its main ingredient, a ratio (P / B) of the ceramic powder with respect to the binder and plasticizer being controlled to 1.33 to 5.56 (however, excluding 5.56).

This invention has disclosed a kind of synthetic method to paclitaxol and side chain of its analogue. This invention using low-cost alpha- glycolic acid as raw material, the asymmetry addition reaction induced by chirality tertiary butyl sulfinamide as committed step, prepares paclitaxol and polyene paclitaxol side chain. The chemical product quotiety of key reaction is high, protecting group is easy to control and operate, synthesis process is short.

The invention discloses a production method of flumioxazin. The production method comprises the following steps: by using 2,4-difluoronitrobenzene as an initial raw material, sequentially carrying out nitrification to obtain 1,5-difluoro-2,4-dinitrobenzene, and carrying out etherification reaction on the 1,5-difluoro-2,4-dinitrobenzene and butyl hydroxyacetate to obtain butyl 3-fluoro-4,6-dinitrophenoxyacetate; carrying out reduction cyclization with hydrogen to obtain 7-fluoro-6-amino-2H-1,4-benzoxazinyl-3(4H)-one; under alkaline conditions, carrying out alkynylation reaction with propargyl chloride to obtain an intermediate product; and finally, carrying out amidation reaction with 3,4,5,6-tetrahydrophthalic anhydride to obtain the flumioxazin. The production technique of the method has the advantages of short process, mild reaction conditions and cheap and accessible raw materials, and is convenient to operate; and the solvent used in the preparation process is recyclable. The method also has the advantages of high total reaction yield, high product purity, low production cost and low environmental pollution.

The invention belongs to the field of chemical sythensis, and particularly relates to a synthetic method of 2-(5-fluoro-2,4-nitrophenoxy)acetate. The invention aims to solve the technical problem that the separation and purification of a product is difficult, and the production cost is high. For solving the technical problem, the synthetic method of 2-(5-fluoro-2,4-nitrophenoxy)acetate is provided. The synthetic method comprises the following steps: a, reacting 2,4-difluoronitrobenzene with glycolate under the action of an acid-binding agent so as to obtain a mixture of 2-(5-fluoro-2-nitrophenoxy)acetate and 2-(3-fluoro-4-nitrophenoxy)acetate; b, reacting the mixture obtained in the step a with nitric acid to obtain 2-(5-fluoro-2,4-dinitrophenoxy)acetate. According to the synthetic method, raw materials are cheap and easily available, reaction selectivity is good, side reaction is less, product yield in high, reaction condition is mild and easy to control, and process is simple to operate and easy to industrialize.

A slow-releasing cerebral implant of nimustine for treating the cerebral malignant glioma and other cerebromas is prepared from nimustine and polylactate-hydroxyacetate copolymer (PLGA) through preparing slow-releasing microspheres, tabletting and sterilizing.

Production of diacetate fibre / ethane-vinyl acetate mixture is carried out by dissolving EVA 1í½30wt% into organic solvent 10í½70wt%, adding into dioxane 30í½90wt%, mixing, adding into CA 70í½99wt%, dissolving to obtain uniform solution at 35í½45íÒC, using high-molecular EVA as second component and mixtures of two organic solvents as solvent, and regulating composition of mixture and solvent to prepare CA / EVA mixed membrane material. It makes CA / EVA solution prepare porous membrane and densifying membrane and can be used for reverse osmose membrane and penetrating gasification membrane for separating organic mixture. It costs low.

The invention discloses a high-purity high-yield aclidinium bromide preparation method suitable for industrial production. The preparation method comprises the following steps: 1) adding methyl 2,2-di(2-thienyl)-2-hydroxyacetate and TBDMSCl into solvent, dropwisely adding alkali, and reacting at (-10)-30 DEG C for 2-10 hours; 2) mixing 3-(R)-quinuclidinol and anhydrous methylbenzene, adding alkali in batches, stirring at room temperature, adding the product in the step 1) in batches, and performing heating reaction at 50-150 DEG C for 2-20 hours; 3) mixing the product in the step 2) with the solvent, dropwisely adding acid under a low-temperature condition, reacting for 1-15 hours, regulating the pH value after the reaction is completed, and cooling; and 4) mixing the product in the step 3) with the solvent, adding 3-phenoxypropyl bromide, performing heating reaction at 50-100 DEG C for 1-5 hours, and purifying after the reaction is completed. The preparation method is simple and convenient; the prepared product has high purity and less side reaction; and the preparation method is suitable for large-scale industrial production.

The invention discloses a preparation method for 2-aryl-2-glycollic acid esters. The preparation method includes the following steps: dissolving the compound in formula I (refer to the description) in an organic solvent; adding a metal reducing agent and an acid medium; reacting for 4-12 hours at 4-25 DEG C; obtaining the compound in the formula II through aftertreatment after the reaction is finished. A metal-acid-alcohol reduction system is adopted, so that keto carbonyl groups in alpha-ketoester (or alpha- aldehyde-ester) can be successfully reduced into hydroxyl, and other groups in ester groups and aromatic rings are not affected, as a result, a high purity product with relatively high yield can be obtained. Compared with the NaBH4-MeOH-AcOH-DMF reduction system reported in documents, the preparation method has the following benefits: cheap metals are used as the reducing agent, alcohol is used as the organic solvent, and the acid medium is used as a hydrogen supply reagent, the condition is gentle, the operation is simple, side reaction is greatly reduced, reaction yield is effectively improved, the production cost is reduced, and the preparation method is suitable for industrial production.

The invention relates to the technical field of modified polymer materials, and especially relates to a polyurethane polymer capable of rapidly decomposing, a preparation method and applications thereof. The polyurethane polymer comprises hard sections and soft sections, wherein the hard sections comprise analogous glycolic acid structures. Degradable analogous glycolic acid structures are introduced into the polyurethane hard sections of the polyurethane polymer, and the structures are easy to degrade in natural environment; furthermore the polymer has a good mechanical performance and processing property, and can be applied to fields of food package, ground film, synthesis leather, and shoe materials.

The invention discloses a planting method for lowering waxberry pest and disease damage. The method is characterized by comprising the following steps of interplanting, wherein in late Autumn, lantanacamara branches are cut out and immersed in a rooting solution to be soaked, organic fertilize and nitrogen, phosphorus and potassium compound fertilizer are applied outside the range being 25-30 cmaway from waxberry trees in diameter, and then cutting planting is conducted; winter control, wherein before snowing in winter, the waxberry trees are pruned, spray cleaning is conducted with brine, protection liquid is used for brushing the whole trees, and then fertilization pits are dug by taking the waxberry trees as the center for applying the organic fertilizer; spring management, wherein inearly March, the organic fertilizer and the nitrogen, phosphorus and potassium compound fertilizer are applied, and cellulose hydroxyacetate and chitosan are added in plant extracts, stirring and mixing are conducted, and the mixture is sprayed to waxberry stems and branches; fruit period management, wherein after waxberry fruiting, a protective shed is built with a 40-mesh nylon net, the plant extracts are used for spraying fruits regularly, and one solar broadband light trap is arranged in the middle of every four waxberry trees.

The invention discloses environment-friendly printing ink which is prepared from the ingredients in parts by weight: 15 to 25 parts of ethyl acetate, 5 to 10 parts of hydroxyl acetate, 10 to 15 partsof carboxyacetate, 50 to 80 parts of butanone, 10 to 15 parts of dye, 2 to 5 parts of conducting salt auxiliary, 1 to 3 parts of lubricant, 0.5 to 2 parts of flatting agent, 1 to 3 parts of defoamingagent and 1.5 to 2.5 parts of adhesion promoter. The invention further discloses a preparation method of the printing ink. The method comprises the steps: (1) weighing 15 to 25 parts of the ethyl acetate, 5 to 10 parts of the hydroxyl acetate and 10 to 15 parts of the carboxyacetate, dissolving into 50 to 80 parts of the butanone and magnetically stirring for 10 to 12h under the condition of 50 to60 DEG C water bath to obtain a resin mixed solution; (2) adding 10 to 15 parts of the dye when the resin mixed solution is cooled to room temperature, stirring for 2 to 3h, then adding 2 to 5 partsof the conducting salt auxiliary, 1 to 3 parts of the lubricant, 0.5 to 2 parts of the flatting agent, 1 to 3 parts of the defoaming agent and 1.5 to 2.5 parts of the adhesion promoter, evenly stirring and adjusting a viscosity to obtain the environment-friendly printing ink. The printing ink disclosed by the invention has the advantages of short drying time, good stability, safety and environmental friendliness.

The invention discloses a compounding method for 2-thiopheneacetyl chloride and belongs to the technical field of organic synthesis. The 2-thiopheneacetyl chloride is compounded by taking thiophene asa raw material through following three-step reaction: 1) acquiring 2-thiophene acetate through the F-C reaction of thiophene and glycolate under the existence of catalyst; 2) hydrolyzing the 2-thiophene acetate under the existence of acid, thereby acquiring 2-thiopheneacetic acid; 3) treating the 2-thiopheneacetic acid in the manner of acylating chlorination with thionyl chloride under the catalysis of pyridine, thereby acquiring 2-thiopheneacetyl chloride. The compounding method for 2-thiopheneacetyl chloride has the characteristics of easily acquired raw materials and simple and convenientoperation and is suitable for industrial production.

The invention discloses a method for effectively inhibiting synthesis of N-Hydroxyacetylneuraminic acid in meat products. The method comprises: administering a live animal to a meat product, and administering the skin as a suede by oral administration. The compound was prepared into a 1 mL solution using a 0.5% sodium carboxymethylcellulose solution, and the amount of perfusion was 1 mL / d, and thestomach was administered for 29 to 31 days. The invention adopts the natural flavonoid quercetin to inhibit the substrate of CMP-Neu5Ac hydroxylase, thereby affecting the activity of CMP-Neu5Ac hydroxylase, thereby reducing the synthesis of Neu5Gc, and performing N-hydroxyacetate nerve from the pre-slaughter living body. The intervention of biochemical synthesis of acid is low in cost and the effect is more obvious.

The invention discloses a graphene-reinforced epoxy ceramic coating. The graphene-reinforced epoxy ceramic coating is prepared from dolomite, silicon carbide powder, corn starch, polyethylene glycol siloxane, alumina, graphene oxide, aniline, hydrochloric acid, an ammonium persulfate solution, sodium hexametaphosphate, tributyl phosphate, propylene glycol butyl ether, titanium dioxide, magnesium oxide, barium sulfate, alcohol amine diphosphoacyloxy hydroxyacetate titanate, glass fibers, epoxy resin E-44, a diluent 660A, triglycidyl p-aminophenol, diethylaminopropylamine, water glass, polyacrylamide and an appropriate amount of deionized water. The graphene-reinforced epoxy ceramic coating can form a dense and smooth coating layer with excellent characteristics such as firmness the same toceramic, high adhesion, uniform thickness, water resistance, corrosion resistance and excellent electrical insulation performances.

The invention discloses a method for synthesizing 6-amino-7-fluorine-2H-1, 4-benzoxazine-3-(4H)-ketone. 2, 4, 5-trichlorine-nitrobenzene serves as a raw material, the 2, 4, 5-trichlorine-nitrobenzeneand fluorinating agent are subjected to fluorination reaction to obtain 2, 4-difluoro-5-chlorine-nitrobenzene, the 2, 4-difluoro-5-chlorine-nitrobenzene and hydroxy acetate are subjected to etherification reaction to obtain 2-(5-fluorine-4-chlorine-2-nitrophenoxy) acetate, the 2-(5-fluorine-4-chlorine-2-nitrophenoxy) acetate and sodium amide react to obtain 2-(5-fluorine-4-amido-2-nitrophenoxy) acetate, and the 2-(5-fluorine-4-amido-2-nitrophenoxy) acetate is catalyzed, hydrogenated and reduced to obtain 7-fluorine-6-amino-2H-1, 4-benzoxazine-3-(4H)-ketone. Reaction technological conditions inall steps are mild, operation is simple and convenient, the method is high in safety and short in reaction time, and industrial production can be popularized.

The invention relates to the technical field of modified polymer materials, and especially relates to a polyurethane polymer capable of rapidly decomposing, a preparation method and applications thereof. The polyurethane polymer comprises hard sections and soft sections, wherein the hard sections comprise analogous glycolic acid structures. Degradable analogous glycolic acid structures are introduced into the polyurethane hard sections of the polyurethane polymer, and the structures are easy to degrade in natural environment; furthermore the polymer has a good mechanical performance and processing property, and can be applied to fields of food package, ground film, synthesis leather, and shoe materials.

Recombinant processes are provided whereby additional genes are introduced into E. coli which have been genetically engineered to produce PHA so that the improved strains produce PHA homopolymers and copolymers directly from diols. In preferred embodiments, PHAs containing 4-hydroxybutyrate monomers are produced directly from 1,4-butanediol; PHAs containing 5-hydroxyvalerate are produced from 1,5-pentanediol; PHAs containing 6-hydroxyhexanoate (6HH) are produced from 1,6-hexanediol; PHAs containing 3-hydroxypropionate are produced from 1,3-propanediol; PHAs containing 2-hydroxypropionate (lactate) are produced from 1,2-propanediol (propylene glycol); PHAs containing 2-hydroxyethanoate (glycolate) are produced from 1,2-ethanediol (ethylene glycol). Genes encoding these same enzyme activities can be introduced or their expression amplified in wild type PHA producers to improve the production of PHA homopolymers and copolymers directly from diol and other alcohol feedstocks. The PHA polymers are readily recovered and industrially useful as polymers or as starting materials for a range of chemical intermediates.

The invention relates to a method for recovering hydroxyacetate from phenoxyacetic acid pesticide wastewater. The method comprises the following steps: carrying out concentrations desalting on wastewater for producing phenoxyacetic acid pesticides under reduced pressure heating conditions to obtain a wastewater concentrate mother liquor containing hydroxyacetic acid; and continuously reacting the wastewater concentrate mother liquor with alcohol in the presence of acidic cation exchange resin as a catalyst to obtain hydroxyacetate. Compared with the prior art, the method adopting the acidic cation exchange resin to substitute other acids as a catalyst has the advantages of technologic process simplification, reduction of the wastewater discharge amount, and recycling and reuse of the catalyst.

A synthetic method for producing hydroxyacetate comprises: taking glycolic acid and alkanol as raw materials, taking 732-type and D001-type cation exchange resins as a solid acid catalyst, and using a reactive rectification column consisting of a rectification section, a stripping section, and a middle multi-kettle gas-liquid phase in sequence for continuous preparation of hydroxyacetate. The conversion rate and yield in an esterification process of hydroxyacetate is improved through controlling technical operation conditions, such as the mass ratio of glycolic acid to alkanol, the reaction temperature, and the consumption of the catalyst, in feeding. In a reactive rectification device, the operation conditions are that the mass ratio of alkanol to glycolic acid is 5:1, and each reactor has the reaction temperature being 70-80 DEG C, the column temperature being 90-110 DEG C, and the column top reflux ration being 0.3-0.5. The esterification conversion rate (based on hydroxyacetate) can reach more than 91%, and the yield of hydroxyacetate can normally reach more than 90%. Compared with a batch tank stirring esterification device in the prior art, the device in the method has large processing capacity and operational convenience, and is suitable for massive industrial production.

The invention discloses a no-clean cleaning agent for an automotive interior trim. The no-clean cleaning agent is characterized by including the following aspects that the no-clean cleaning agent is prepared from absolute ethyl alcohol, glycerol, soybean, fructus gleditsiae sinensis, cellulose hydroxyacetate, protease and the like by processing; a processing method of the no-clean cleaning agent comprises the following steps: (1), preparation: soaking the soybean, then pulping to make soybean milk, pressurizing the soybean milk, carrying out oscillation treatment by using an ultrasonic wave, then juicing the fructus gleditsiae sinensis, filtering, afterwards, raising a temperature, and cooking; (2), solvent confection: adding the absolute ethyl alcohol, the glycerol, the cellulose hydroxyacetate and camellia seed oil into water, agitating and mixing to subsequently prepare a solvent solution; (3), mixing: raising a temperature of the solvent solution, adding a soybean extract, fructusgleditsiae sinensis liquid, a willow leaf extracting solution and a pistacia weinmannifolia extract, lowering the temperature to a room temperature, then adding the protease, amylase and magnesium chloride, homogenizing and agitating to subsequently prepare a preliminarily prepared cleaning agent; (4), filtration: putting an electrode into the preliminarily prepared cleaning agent, loading an electric current, carrying out ionization treatment, standing, then filtering by using a microfiltration membrane, and bottling to subsequently prepare the cleaning agent.

The invention belongs to the technical field of chemical synthesis, and concretely relates to a catalytic synthesis method of n-butyl hydroxyacetate. The method comprises the following steps: carrying out a refluxing dehydrating esterification reaction on glycolic acid and an excess amount of n-butanol under the catalysis of acidic ion exchange resin, filtering, and distilling to synthesize n-butyl hydroxyacetate, wherein the acidic ion exchange resin is preprocessed by a buffer solution. Processing of the acidic ion exchange resin by the buffer solution with a certain pH value greatly improves the synthesis yield and selectivity of n-butyl hydroxyacetate. The method has the advantages of low device requirements, no corrosion and few three wastes, and is especially suitable for amplified production.

A novel preparation method of 16 alpha-hydroxyprednisolone comprises the following steps: dissolving 17-prednisone dehydroxyacetate as a raw material in an organic solvent, oxidizing a 16-position double bond and a 17-position double bond with potassium permanganate under acid catalysis to obtain an oxide, dissolving the obtained oxide in the organic solvent, adding acetone, and carrying out acidcatalysis reaction to obtain a protective substance; then dissolving the protective substance in an organic solvent, adding a reducing agent to reduce the 11-position ketone, and directly adding an acid aqueous solution to perform hydrolysis and deprotection after the reduction reaction to obtain the 16 alpha-hydroxyprednisolone, and dissolving 16 alpha -hydroxyacetate in an organic solvent, hydrolyzing 21-position acetic ester under the catalysis of solid-phase base to obtain 16 alpha -hydroxyprednisolone. Although two steps of the protection reaction and deprotection reaction are added, thereaction yield of each step unit is high, and the operation is simple and convenient, and the process is economical and environment-friendly, and the total synthesis yield is greatly improved; and compared with the traditional production method, the preparation cost of the method is reduced by 20-25%.

The invention provides a method for preparing 3-morpholone. The method comprises the steps that halogen hydride removing is carried out on 2-halogenated ethylamine hydrohaloate under the condition oforganic solvent existing, an obtained reaction system and 2-glycollic acid ester are mixed and then subjected to amine ester exchange reaction to obtain 2-(2-hydroxyacetamido) halothane; ring closurereaction is carried out on the 2-(2-hydroxyacetamido) halothane under the condition of alkali reagent and organic solvent existing to obtain the 3-morpholone. The method for preparing the 3-morpholonehas the advantages that the technology side reaction is less, the product purification is convenient; the operation is simple, the safety is high, the method is environmentally friendly; raw materials are obtained easily, the price is low; the product yield is high (reaches 75.5%), the purity is high (reaches 99% or above), the method is suitable for the industrialized batch production, and the industrialized prospect is good.

The invention discloses a new material for surgical suture. The surgery suture use novel material is prepared from, by weight, 15-23 parts of methyl 2-hydroxyacetate, 5-8 parts of ossein, 11-14 parts of polyamide, 0.5-0.9 part of indole, 0.4-0.8 part of mock-strawberry extractive, 2-4 parts of pseudo-ginseng powder and 0.01-0.05 part of Nisin. The new material for surgical suture is free of toxicity, harm and residue, is formed through processing easily, is high in intensity and easy to knot, has excellent performances such as good softness and disinfection and sterilization resistance, can promote wound healing, and can be absorbed and degraded completely in 15-25 days in biological tissue.

The invention belongs to the field of chemical synthesis, in particular to a synthesis method of 2-(5-fluoro-2,4-dinitrophenoxy) acetate. The technical problem to be solved by the invention is that the separation and purification of the product is difficult and the production cost is high. The scheme of the present invention to solve the above-mentioned technical problems is to provide a kind of synthetic method of 2-(5-fluoro-2,4-dinitrophenoxy) acetate, comprising the following steps: a, 2,4-difluoronitrophenoxy Benzene reacts with glycolate under the action of an acid-binding agent to obtain 2‑(5‑fluoro‑2‑nitrophenoxy) acetate and 2‑(3‑fluoro‑4‑nitrophenoxy) acetic acid A mixture of esters; b, reacting the mixture obtained in step a with nitric acid to obtain 2-(5-fluoro-2,4-dinitrophenoxy) acetate. The invention provides cheap and easy-to-obtain raw materials for the synthesis method, good reaction selectivity, less side reactions, high product yield, mild reaction conditions and easy control, simple process operation and easy industrialization.

The invention discloses a method for synthesizing 2-(5-fluoro-1, 5 dinitro-phenoxy) acetate. 2, 4-dichloronitrobenzene serves as a raw material, nitration reaction is performed to obtain 2, 4-dichloro-1, 5-dinitrobenzene, the quantity of fluorinating agents and reaction conditions are controlled in aprotic polar solvents DMF, fluorination reaction with potassium fluoride is performed to obtain 2-fluoro-4-chloro-1, 5-dinitrobenzene, and the 2-fluoro-4-chloro-1, 5-dinitrobenzene is polarized in the etherified aprotic polar solvents DMF and subjected to etherification reaction with hydroxy acetate under the action of acid-binding agents and catalysts to obtain the 2-(5-fluoro-1, 5 dinitro-phenoxy) acetate. In addition, raw materials are inexpensive and easy to obtain, operation is simple andconvenient, technological conditions of reaction in all steps are mild, the method is high in safety and short in reaction time, and industrial production can be popularized.

This patent describes economical and environment-friendly processes for the synthesis of Mg-containing non-Al anionic clays. It involves a one-step process wherein a suspension comprising a trivalent metal source and at least a magnesium containing source as a divalent metal source is reacted to obtain a magnesium-containing non-Al anionic clay. The anionic clay has interlayers containing anions comprising hydroxycarbonate, carbonate, bicarbonate, acetate, hydroxyacetate, oxalate, nitrate, hydroxyl, and / or formate or mixtures thereof. There is no necessity to wash or filter the product. It can be spray dried directly to form microspheres or can be extruded to form shaped bodies. The product can be combined with other ingredients in the manufacture of catalysts, absorbents, pharmaceuticals, cosmetics, detergents, and other commodity products that contain anionic clays.

The invention discloses a new structural 20-hydroxy-16 alpha-brom-steroidal compound, synthesizing method (a, acyl hydrolysis) and application (b, fragmentation rearrangement), which comprises the following steps: adopting 20-glycolic ester-16 alpha-brom-steroidal compound as raw material to obtain 20-hydroxy-16 alpha-brom-steroidal compound; fragmenting; rearranging to obtain androste-16-olefin-3beta-alcohol as key intermediate to synthesize pig ectohormone androste-16-olefin-3-ketone and androste-16-olefin-3 alpha-alcohol.

The invention discloses a new structural 20-hydroxy-16 alpha-brom-steroidal compound, synthesizing method (a, acyl hydrolysis) and application (b, fragmentation rearrangement), which comprises the following steps: adopting 20-glycolic ester-16 alpha-brom-steroidal compound as raw material to obtain 20-hydroxy-16 alpha-brom-steroidal compound; fragmenting; rearranging to obtain androste-16-olefin-3 beta-alcohol as key intermediate to synthesize pig ectohormone androste-16-olefin-3-ketone and androste-16-olefin-3 alpha-alcohol.