The invention relates to a method for extracting total triterpenoids and monomer ilicin A of enriched Hainan holly leaf. The method is characterized by comprising the following extraction steps that raw materials of Hainan holly leaf is subjected to reflux extraction by 50 percent to 95 percent of ethanol, liquid supernatant and a precipitation part are obtained after the extraction liquid is concentrated and centrifuged, the precipitation part is subjected to mixed suspension by 30 percent to 40 percent of ethanol, then, petroleum ether is used for extraction, the lower layer solution is subjected to pressure reduction, concentration and drying to obtain total triterpenoids; in addition, the ethanol extraction liquid is subjected to pressure reduction, recovery and evaporation to dryness, water is used for dissolving, acid is added for hydrolysis, organic solvents are extracted, the recovery to dryness, the silicagel column coating and the sherwood oil-ethyl acetate gradient elution are carried out, eluant is collected, elution solvents are recovered through pressure reduction, and the monomer ilicin A is obtained. According to an extraction enriching method, the total triterpenoids content of the obtained product exceeds 50 percent, the purity of the monomer ilicin A is high, meanwhile, the repeatability and the stability of the method are good, the transfer rate of effective ingredients of the raw material is high, the cost is low, the operation is simple and convenient, and the method is suitable for industrial production. Meanwhile, the invention also relates to application of the total triterpenoids and the monomer ilicin A of Hainan holly leaf in the cardiovascular disease treating aspect, in particular to the atherosclerosis aspect, and the potential development value is realized.