82results about How to "Realize industrial preparation" patented technology

The invention provides a double safety and effectiveness inspection method of human lumbar bone and implant, and belongs to the field of medicine. The method comprises the following steps: acquiring a 3D (three-dimensional) rendering model of lumbar body bone, lumbar disc and interspinous ligament by a 3D reconstruction technology; performing 3D grid division to the 3D rendering model, and giving attributes of a heterogeneous material to the 3D rendering model; performing 3D modeling to an implant; assembling the lumbar body bone, the lumbar disc, the interspinous ligament and the implant, and analyzing stress and strain of the assembly by adopting uniformly distributed nodal load through a finite element analysis method; simulating visible finite element analysis by a computer before the implant is implanted into a human body. Therefore, the verification requirement to bone and implant double safety and effectiveness can be fulfilled, the damage of the implant to original human lumbar bones can be prevented, double safety and effectiveness of the bones and implant can be guaranteed, the manufacture cost can be effectively reduced along with convenience and quickness, and individual and industrial manufacturing of a human lumbar bone implant can be realized. The method is applicable in the field of implant stress-strain analysis in the orthopedics department.

The invention belongs to the technical field of photoelectric functional nano-materials, and particularly relates to a flexible transparent conductive oxide nanofiber membrane and a preparation method thereof. A precursor is composed of salt of a metallic oxide, salt of a doped element, an adhesive and a solvent, the precursor is sprayed on a substrate through electrospining equipment, and then high-temperature calcination is carried out to obtain the flexible transparent conductive oxide nanofiber membrane. The flexible transparent conductive oxide nanofiber membrane prepared with the method has flexibility, high conductivity and high visible-light permeability; no flexible substrate material is needed, and use of the flexible transparent conductive oxide nanofiber membrane is facilitated; the flexible transparent conductive oxide nanofiber membrane prepared with the electrostatic spinning method is controllable in size, high in repeatability, simple in process, high in efficiency and low in cost, and industrial preparation can be achieved.

The invention relates to a circular revolving brush electrostatic spinning device comprising a liquid supplying system, a brush type spinning system and a nano-fiber collecting system. The brush type spinning system comprises a brush head, a brush shaft, a cylindrical seat and a metal annular sprayer; the brush head is installed on the tail end of the brush head; the cylindrical seat is mounted on the brush shaft; the metal annular sprayer is arranged in a place on the upper end of the cylindrical seat and corresponding to the brush head; a bearing is arranged on the lower end of the cylindrical seat and on the brush shaft; the bearing is connected with a motor via a belt; the liquid supplying system has an air bottle, a spinning liquid storage bottle and a liquid guiding pipeline; the liquid guiding pipeline is disposed in the brush shaft; the upper end of the liquid guiding pipeline is connected with the brush head and the lower end extends into the bottom of the spinning liquid storage bottle; and the spinning storage bottle is connected with the air bottle via an air pipe. High-polymer solution can be automatically fed and nano-fibers can be prepared in batches in a stable way; and meanwhile, problems of volatilization of solvent during the electrostatic spinning and uncontrollability of the nano-fiber structure can be solved.

The invention belongs to the technical field of photoelectric functional nanometer materials, and particularly relates to a high-transparent flexible metal nanofiber membrane and a manufacturing method of the high-transparent flexible metal nanofiber membrane. The manufacturing method mainly comprises the steps that firstly, polymer nanofibers are prepared through electrostatic spinning to serve as a substrate; then, metallic compounds are deposited on the surfaces of the polymer nanofibers through the electrostatic spraying method, and organic matter fiber cores are removed through pyrogenic decomposition to obtain hollow inorganic metal nanofibers; finally, a reduction reaction is carried out to obtain the high-transparent flexible hollow metal nanofiber membrane. The metal nanofiber membrane manufactured through the method has the characteristics of flexibility, high conductivity, high visible light permeability and near-infrared ray reflectivity. The transparent flexible conductive metal nanofiber membrane manufactured through the electrostatic spinning method is controllable in size, high in repeatability, simple in process, high in efficiency, low in cost and suitable for industrialized preparation.

The invention discloses a one-way impulse type wave power generation device which comprises a water absorbing cabin, an air cabin, a flotation tank, an inlet elbow, an outlet straight pipe, a first flange plate, an installation pipe, a one-way impulse type air turbine and a power generator. The air cabin and the water absorbing cabin are jointed through a bolt and are separated through a rotatablealuminum alloy cover plate; a fixing block and a first fixing ring are arranged in the air cabin; the aluminum alloy cover plate is provided with a movable rod arranged in the first fixing ring in apenetrating way and rotating around the first fixing ring; a first end of the inlet elbow is arranged in the water absorbing cabin under the aluminum alloy cover plate; a second end of the inlet elbowis arranged on the upper part of the flotation tank and is provided with a second fixing ring; a rubber sheet capable of clinging to or loosening the second fixing ring is arranged in the second endof the inlet elbow; and the outlet straight pipe is arranged on the upper part of the air cabin and is connected with the installation pipe and the one-way impulse type air turbine through the first flange plate. According to the one-way impulse type wave power generation device provided by the invention, high-efficient conversion from wave energy to air kinetic energy to electric energy is realized, and the energy conversion efficiency is high.

The invention discloses a 3D model constructed in vitro by means of a serum-free culture medium as well as a construction method of the 3D model and relates to the technical field of biological materials in tissue engineering. Due to selection variety of seed cells and good in-vitro construction repeatability, industrial preparation of the 3D model can be realized. The model is an in-vitro model formed by primary corneal epithelial cells subjected to tissue isolation, limbal stem cells, immortalized corneal epithelial cells, primary oral epithelial cells or oral mucosa squamous cancer cell lines TR146 subjected to in-vitro amplification and stratified through the serum-free culture medium with an undersurface-gas-liquid surface staged culture method.

The invention discloses a bionic moisture-permeable and sweat-discharge yarn and a preparation device and method thereof. The moisture-permeable and sweat-discharge yarn is internally provided with a tree-shaped cross network channel for simulating an internal water conveying channel of a plant. The preparation device comprises an insulating conical cover, and air nozzles are symmetrically arranged on the two sides of the inner wall of the insulating conical cover; a metal rod with a metal circular ring at one end is arranged on the lower portion of each air nozzle, and an electrostatic spinning sprayer is arranged below each metal circular ring. The preparation method comprises the steps that yarns of core layer fibers penetrate through the center from the bottom of the insulating conical cover to the top of the insulating conical cover, and air in the insulating conical cover spirally moves along the inner wall at a high speed to drive electrostatic spinning nanofibers to move spirally, so that the yarns are wrapped with the nanofibers, and the prepared moisture-permeable and sweat-discharge yarns are exposed from the top of the insulating conical cover. The water guiding channel in the plant is simulated, the pressure difference formed due to different sizes of the gaps of the surface and inner layers is used for generating the differential effect, the moisture guiding capability is obviously enhanced, and the one-way moisture guiding capacity is achieved.

The inventi relates to a monatomic platinum doped nano porous metal compound catalyst and a preparation method and application thereof. According to the micro-dissolution phenomena of platinum counterelectrodes under long-term hydrogen evolution conditions, a cyclic potential method is used for doping monatomic platinum into a nanoporous metal compound to obtain the monatomic platinum doped nanoporous metal compound catalyst. The monatomic platinum doped nano porous metal compound catalyst has the electrocatalytic hydrogen evolution performance comparable to or even surpassing that of a commercial Pt/C catalyst at full pH. The preparation process is simple and controllable, the cost is low, the catalyst is environmentally friendly, large-scale and industrialized product can be achieved,and it shows that the catalyst has a broad application prospect.

The invention discloses a preparation method of a fluorine-doped lithium-rich manganese-based positive electrode material. The lithium-rich manganese-based positive electrode material has a chemical general formula of xLi2MnO3.(1-x) LiMO<2-y>F<2y>, wherein x is larger than or equal to 0.1 and smaller than or equal to 0.9, y is larger than 0 and smaller than or equal to 0.05, and M is one or more of Ni, Co, Mn, Cr, Fe, Ti, Mo, Ru, V, Nb, Zr and Sn. The preparation method comprises the following steps of: preparing a fluorine-doped lithium-rich manganese-based precursor through a precipitation reaction by adopting soluble metal salt, a precipitator, a soluble fluorine-containing compound and water; and uniformly mixing the fluorine-doped lithium-rich manganese-based precursor with a lithium salt, and carrying out presintering and high-temperature sintering to obtain the fluorine-doped lithium-rich manganese-based positive electrode material. According to the method, the soluble fluorine-containing compound is used as a fluorine source, fluorine doping is synchronously realized during coprecipitation of the lithium-rich manganese-based precursor, the doping uniformity is relatively good, and the cycle performance of the doped lithium-rich material is greatly improved.

The invention relates to the technical field of electrochromic thin films, in particular to a brown electrochromic charge storage electrode and a preparation method. By means of a vacuum vapor deposition mode, a transparent conducting layer and a LiFe(WO4)2 electrochromic charge storage layer are deposited on a transparent substrate, crystallization is carried out after annealing treatment is carried out, and the electrochromic electrode with the charge storage function is successfully prepared. A LiFe(WO4)2 thin film serves as the electrode charge storage layer and is a cathode off-color material. The charge quantity storage capacity of the electrode is high, pre-lithiation is not needed, the oxidation state transmittance is high, the special adjustment function between brownness and the transparent state is achieved, and the advantages of being good in cycle performance, low in drive voltage, high in environmental suitability and the like are achieved.

The invention provides a preparation method and application of a target exosome which can effectively improve the modifying efficiency of an exosome so as to realize large-scale preparation, a drug delivery system and a drug. The preparation method of the target exosome comprises the following steps S1, performing sulfhydrylation treatment on a target antibody so as to obtain a sulfhydrylation target antibody; and S2, enabling the sulfhydrylation target antibody to be connected with the exosome through a protein cross-linking agent. The target antibody is subjected to sulfhydrylation modification, so that an amino on the antibody is converted into a sulfydryl; and then the exosome and the antibody are in cross-linking combination so that the target exosome is obtained. Compared with a method of obtaining the target exosome through modification in a plasmid transfection manner in the prior art, the preparation method provided by the invention has the advantages that the problems that the transfection efficiency is low in the plasmid process and large-scale preparation and secretion of mother cells through genetic engineering plasmid transfection are difficult to perform can be solved, industrialization preparation of the target exosome can be realized, and the preparation method has important significance in research and application of the exosome as a delivery carrier and a drug carrier.

The present invention discloses a method for producing a colloidal silica using silicon metal as a raw material, which enables to produce a colloidal silica having high concentration and low viscosity. Also disclosed a method for producing a colloidal silica using silicon metal as a raw material, which enables to produce a colloidal silica in short time with high yield without comprising a concentration step. Further disclosed is a method for producing a colloidal silica, which enables to easily control the particle size of silica contained in a colloidal silica. Specifically disclosed is a method for producing a colloidal silica comprising a step for obtaining a colloidal silica by reacting silicon metal (Si) with water in an aqueous solution containing an alkaline catalyst and a dispersing agent, wherein the dispersing agent is composed of one or more ionic substances selected from inorganic acids, organic acids and their salts. Also specifically disclosed is a method for producing a colloidal silica comprising a step for controlling the particle size of silica by adjusting the addition rate of silicon metal into an aqueous solution containing an alkaline catalyst and a dispersing agent.

The invention provides a production line of an electrostatic spinning nanofiber membrane. The production line comprises a base fabric unwinding device, a vertical and horizontal tension regulating device, an electrostatic spinning box body, a drying device, a protective layer base fabric unwinding device and a winding device, wherein the base fabric unwinding device is used for unwinding non-wovenbase fabric and conveying the unwound non-woven base fabric to the electrostatic spinning box body, even unfolding of base fabric in the vertical and horizontal direction in a working area of the electrostatic spinning box body is ensured through the vertical and horizontal tension regulating device so as to collect the produced nanofiber membrane on the base fabric, and protective layer base fabric is covered on the surface of the nanofiber membrane through the protective layer base fabric unwinding device; and the drying device is used for evaporating residual solvents in the nanofiber membrane covered by the protective layer base fabric and shaping the nanofiber membrane, and the winding device is used for winding the dried nanofiber membrane. The system has a simple structure and convenient operation, and wide-width electrostatic spinning nanofiber membrane can be produced effectively, continuously and stably, so that industrial preparation of the electrostatic spinning nanofiberis achieved.

The invention discloses a gingival epithelium model and an in-vitro building method thereof. The method is characterized by including following steps: step 1, primary culture and amplification of gingival epithelium cells; step 2, inoculation culture of gingival epithelium cell sap; step 3, proliferation and differentiation culture of a gingival epithelium model air-liquid face. Human-derived gingival epithelium cells are used, so that model structure and function are closer to normal human gingival epithelium tissue, and detection indexes can be reflected more really; in-vitro building is high in repeatability, and industrial preparation can be realized; an air-liquid face staged culture method ensures different nutritional needs of cells in different stages, shortens building time and lowers production cost; by adding factors into a culture medium, normal stratifying of the model is ensured, influence of this own structure and extracellular microenvironment can further improve a barrier function of the model, and a finally-built in-vitro gingival epithelium model is highly similar to human gingival epithelium tissue in structure and function.