Compositions and methods for promoting brain health are provided. The present disclosure provides a composition comprising an
active ingredient encapsulated in a suspension of particles comprising a
biodegradable polymer containing an effective amount of the
active ingredient, the particles being configured to bypass the blood-brain barrier, the nutritional supplement being synthetic D-
beta hydroxybutyrate, and the targeted delivery being to the brain. Also provided are methods for promoting brain healing after
traumatic brain injury, including
neuroinflammation, and methods for promoting brain health. Further provided is a pharmaceutical composition for use in reducing the risk of
brain damage due to acquired brain injury in a subject susceptible to or otherwise at risk for acquired brain injury, the composition comprising a pharma- ceutically acceptable carrier and a formulation comprising a therapeutic amount of an API, where the API is synthetic D-
beta hydroxybutyrate, and the treatment comprises targeted delivery to the olfactory region of the subject's
nasal cavity by intranasal administration of the composition (a) before the subject participates in an event where acquired brain injury is a known risk, (b) after the subject participates in the event, or both, for use in treating a symptom of acquired brain injury in a subject, including
neuroinflammation, and wherein the treatment is neuroprotective.