56 results about "Beta hydroxybutyrate" patented technology

Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of (2-7 mmol/L), with or without dietary restriction. The combination results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance in a short period of time. Further, use of these supplements to achieve ketosis yields a significant elevation of blood ketones and reduction of blood glucose levels. Use of these substances does not adversely affect lipid profiles. By initiating rapid ketosis and accelerating the rate of ketoadaptation, this invention is useful for the avoidance of glucose withdrawal symptoms commonly experienced by individuals initiating a ketogenic diet, and minimizes the loss of lean body mass during dietary restriction.

Ketogenic compositions including a beta-hydroxybutyrate (BHB) mixed salt are formulated to induce or sustain ketosis in a subject to which the ketogenic compositions are administered. The BHB mixed salt is formulated to provide a biologically balanced set of cationic electrolytes, and is formulated to avoid detrimental health effects associated with imbalanced electrolyte ratios. A ketogenic composition includes BHB salts of at least sodium, potassium, calcium, and magnesium. The BHB salts may also include at least other component such as a BHB compound containing other cations, such as transition metal cations (e.g., zinc or iron), a BHB-amino acid salts, medium chain fatty acid source, vitamin D₃, flavorant, or other excipient.

The invention discloses a method for preparing a composite board capable of simultaneously slowly releasing nitrogen and adsorbing/biologically degrading petroleum hydrocarbons. The method comprising the steps of weighing urea aqueous solution and formaldehyde aqueous solution in the proportion of 6.5:1 and regulating the pH value of the urea aqueous solution to 7.2-7.4; adding formaldehyde into the urea aqueous solution, stirring, regulating the pH value to 3.2-3.4 and adding deionized water to obtain a mixed solution M1; mixing poly(beta-hydroxybutyrate) and chloroform solution of polyethylene glycol in the proportion of 5:1; dropwise adding the M1 into the mixed chloroform solution in the proportion of 1:4; spraying distilled water into a container filled with liquid nitrogen to manufacture ice ball particles, screening, and putting in a mould to compact; pouring the mixed solution into the mould, carrying out freezing shaping and obtaining a composite board after demoulding and freezing; and culturing the composite board in a petroleum hydrocarbon degrading bacteria solution for 24h, drying in the air and obtaining the composite board capable of simultaneously slowly releasing nitrogen and adsorbing/biologically degrading petroleum hydrocarbons. The method disclosed by the invention has the advantages that the manufacturing process is simple; and the obtained composite board is high in petroleum hydrocarbon pollutant treating efficiency and incapable of causing secondary pollution and damage to the water ecological environment.

The invention discloses a metabolism marker for screening and monitoring a colorectal cancer. The metabolism marker is beta-hydroxybutyrate, 5-hydroxytryptamine, lysophosphatidyl choline (C14:0), lysophosphatidyl choline (C16:1), alpha-ketobutyrate, fumaric acid, aspartic acid, 2-octene diacid, glycerin, glyceric acid, tryptophan, aconitate, citric acid, ornithine, glycerol monopalmitate, creatinine, methionine and citrulline. The invention also provides a kit with auxiliary functions of early diagnosis and prognosis monitoring on the colorectal cancer. The application of the micromolecule metabolism marker to monitoring of the colorectal cancer not only greatly improves the accuracy, but also has great guiding significance for development of a subsequent clinical application study.

The invention provides a degradable food packaging film material and a preparation technology thereof, and relates to a high-strength-and-ductility fully-degradable biopolyester composite and a preparation technology thereof. The degradable food packaging film material is characterized by being prepared by taking aliphatic polycarbonate, lactic acid, poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate), 4-arm-polyethylene glycol propionaldehyde, chitosan, 8-arm polyethylene glycol polyhedral oligomeric silsesquioxane, stannous octoate, stannous chloride, a melt reinforcing agent and an antioxidant as raw materials in a reaction extrusion mode. The biomass composite is simple in processing technology, has excellent strength and ductility, can be fully degraded, and can be suitable for packaging and industrial fields requiring high strength and ductility.

Disclosed herein are “ketonnabidiol” compositions including a combination of: (1) cannabidiol (CBD) and/or cannabidiolic acid (CBDA); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketonnabidiol compositions for producing desired physiological effects, such as fat loss, in a mammal. The ketonnabidiol compositions beneficially enhance fat loss through ketosis while also reducing the duration and/or severity of unpleasant “keto flu” symptoms typically associated with ketosis.

The invention provides a composition containing L-carnitine and a beta-hydroxybutyric acid compound, and specifically provides a composition containing the L-carnitine and at least one beta-hydroxybutyric acid compound. The beta-hydroxybutyric acid compound comprises beta-hydroxybutyrate, a beta-hydroxybutyric acid precursor or a combination thereof; and preferably, the L-carnitine and beta-hydroxybutyric acid amino acid exist in the composition in a form of intramolecular salt. The invention furthermore provides a preparation method of the L-carnitine-beta-hydroxybutyrate. The composition provided by the invention is high in stability, high in bioavailability and significant in weight loss effect and ketogenic effect; and the preparation method provided by the invention is easy and convenient to operate.

The present invention is characterized by that 70-92% of poly(beta-hydroxybutyrate), 4-20% of polyethylene glycol oxide, 3.5-20% of cellulose ester and 0.5-2% of adjuvant are uniformly mixed, placed into mould with 60-90 deg.C, then placed in an oil press, and the mould is heated to 160-195 deg.C to make hot-press formation, its pressure is 7-12 MPa, and the time is 20-40 min., then and mould is cooled to below 60 deg.C and demoulded so as to obtain the invented poly(beta-hydroxybutyrate) three-component blend. The melting temp. of said three-component blend is reduced, its toughness is improved and its complete degradability is also retained.

The invention discloses a poly epsilon-caprolactone/poly (beta-hydroxybutyrate-valerate) blend membrane and a preparation method thereof, and belongs to the field of biodegradable materials. The blend membrane is a membrane produced by irradiation modification by an electron beam produced by gamma rays or an electron accelerator, the irradiation dose is 2-70 kGy, the membrane thickness is 20 to 200 microns, and taking the total membrane mass as 100%, the PCL (polycaprolactone) content is 20-80%, and the PHBV (poly hydroxyl butyrate valerate) content is 20-80%. The preparation method is as follows: respectively dissolving PCL and PHBV in solvents to obtain a solution 1 and a solution 2; (2) mixing the solution 1 and the 2 solution to obtain a mixed solution3; (3) casting a glass plate with the mixed solution3 to make the thickness uniform, forming a membrane by solvent evaporation, and obtaining a blend membrane by vacuum drying to a constant weight; and (4) performing irradiation on the blend membrane. According to the blend membrane, mechanical properties of the PCL and the PHBV are complemented, the brittleness of the PHBV is improved, the degradation performance is adjustable, and the method is simple in process and less in environmental pollution.

The invention relates to a high-strength high-toughness fully-degradable bio-polyester composite material and a preparation process thereof. The bio-polyester composite material is characterized by being prepared from aliphatic polycarbonate, lactic acid, poly(beta-hydroxybutyrate-co-beta hydroxyvalerate), four-arm polyethylene glycol propionaldehyde, chitosan and eight-arm polyethylene glycolpolyhedral oligomeric silsesquioxane, stannous octoate, stannous chloride, a melt enhancer and an antioxidant through reactive extrusion. The biomass composite material is simple in processing technology,has excellent strength and toughness, can realize full degradation, and can be applied to packaging and industrial fields requiring high strength and toughness.

The invention discloses a detection reagent and test paper for beta-hydroxybutyrate. The detection reagent contains 3-5 KU/L of diaphorase, 9-13 KU/L of beta-hydroxybutyrate dehydrogenase, 1.2-2.5 KU/L of NAD and 0.6-1.0 KU/L of NBT. The detection reagent contains various specific enzymes for specific proportioning, thereby being capable of realizing rapid detection and more accurate detection. The test paper comprises a reaction base layer, a reaction layer, a blood filter layer and a hydrophilic layer which are stacked to form a siphon system, and rapid detection and more accurate detection are further guaranteed.

The invention discloses a food and drink composition. The food and drink composition is prepared from the following components based on specific content combination: edible vegetable oil, medium chain triglyceride, hydrolyzed small molecular protein powder, dietary fiber powder, nut meat, egg powder, polyols, sodium caseinate, mono and di-glycerin fatty acid ester, docosahexaenoic acid, arachidonic acid, taurine, phosphatidylcholine, phosphatidylserine, mineral substances, vitamins and the like, all components are interacted, the food and drink composition can promote metabolism in the body to produce acetoacetic acid, beta-hydroxybutyrate and acetone through dietary intervention to cause a series of biochemical influences on the brain under a condition of meeting primary nutrients requirement for the growth of autistic children, so as to achieve the effect of intervention treatment of infantile autism. The invention also discloses a preparation method and application of the food and drink composition.

Ketogenic compositions including beta-hydroxybutyrate (beta-hydroxybutyrate) and acetoacetate are formulated to induce, promote, or sustain ketosis in a mammal. The combined beta-hydroxybutyrate/acetoacetate compositions include an amount of acetoacetate that limits the reduction in available NAD⁺ in a subject without causing the formation of excess acetone in the bloodstream. In some aspects a composition for promoting and/or sustaining ketosis in a mammal contains a dietetically or pharmaceutically acceptable carrier and a beta-hydroxybutyrate/acetoacetate mixture of about 5% to about 45% acetoacetate by weight of the mixture and about 55% to about 95% beta-hydroxybutyrate by weight of the mixture.

The invention relates to a cyclophorase determining method and a determining kit for beta-hydroxybutyrate. According to the method, beta-hydroxybutyrate is specifically oxidized by beta-hydroxybutyrate dehydrogenase and Thio-NAD<+>, and acetoacetic acid and Thio-NADH are produced; beta-hydroxybutyrate and NAD<+> are produced by acetoacetic acid in presence of beta-hydroxybutyrate dehydrogenase and NADH; reactions circulate, a large amount of Thio-NADH is produced, the content of beta-hydroxybutyrate can be calculated through determination of the absorbance increase amount rate of the produced Thio-NADH under the condition that the wavelength is 405 nm, the method has an amplification action on trace beta-hydroxybutyrate and has the advantages of high sensitivity, good stability, low cost and the like. The kit comprises NADH, beta-hydroxybutyrate dehydrogenase, Thio-NAD<+>, a buffer solution, a surfactant and a stabilizer. The method can be used for determining the content of beta-hydroxybutyrate through a biochemical analyzer.

The invention provides a preparing method for a modified poly(beta-hydroxybutyrate) composite and relates to the technical field of modification of poly(beta-hydroxybutyrate) and the technical field of degradable plastic.The preparing method comprises the steps that ethylene cellulose (EC) serves as a dispersing phase and is subjected to melt blending with poly(beta-hydroxybutyrate) (PHB) with a proper technology, EC is evenly dispersed in a biodegradable polyester PHB matrix, and a high-performance green polymer material is prepared.In a cellulose-based composite, EC influences the crystal habit and crystallization rate of the matrix polymer, even changes the compatibility and interfacial properties of incompatible blend systems and finally changes the ultimate performance of the matrix polymer, and thus the mechanical property, the crystallization degree and the crystal habit of the composite are controlled.

The invention provides beta-hydroxybutyrate and beta-hydroxyvalerate copolymer powder for selective laser sintering and a preparation method thereof. According to the preparation method, a raw material of beta-hydroxybutyrate and beta-hydroxyvalerate resin powder having shape, property and the like especially suitable for selective laser sintering can be acquired by selecting proper solvent, especially specific temperature and pressure, and designing a proper heating and cooling mode.