323 results about "Cyclohexenes" patented technology

The invention belongs to the field of biological pharmacy and biological conversion, and particularly relates to a lipase mutant and application thereof. The lipase CALB mutant disclosed by the invention is obtained by carrying out single-point mutation or combined mutation on the 40th site, the 134 site, the 154 site, the 189th site, the 278th site and the 281 site of an amino acid sequence as shown in SEQ ID NO.1. Compared with a wild type, the mutant has the advantage that the stereoselectivity is greatly improved when the mutant is used for catalyzing racemization 3-cyclohexene-1-methyl formate to produce (S)-3-cyclohexene-1-formic acid. Compared with a traditional chemical method for preparing (S)-3-cyclohexene-1-formic acid, the lipase CALB mutant provided by the invention is high in stereoselectivity, mild in reaction condition, environment-friendly, low in equipment requirement, capable of greatly reducing the production cost and wide in application prospect in industrial application.

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

The invention discloses cyclohexene formate esterase, a mutant of cyclohexene formate esterase and application of cyclohexene formate esterase in production of (S)-3-cyclohexene-1-formic acid. According to the cyclohexene formate esterase and the mutant disclosed by the invention, 100-400g / L of racemic 3-cyclohexene-1-methyl formate can be split by taking wet thalli subjected to induced expression or crude enzyme liquid obtained by ultrasonically crushing the wet thalli as a catalyst, so that (S)-3-cyclohexene-1-formic acid with chemical purity and optical purity reaching 99% or above is synthesized. The enzyme activity of the cyclohexene formate esterase mutant provided by the invention is further improved, the reaction time and the catalyst dosage are obviously reduced compared with those of a substrate with the same catalysis concentration before mutation, the reaction condition is mild, the operation is relatively simple and convenient, and the cyclohexene formate esterase mutant has a very good industrial application prospect.

The invention provides a 2-succinyl-5-enol acetonyl-6-hydroxy-3-cyclohexene-1-carboxylic acid (SEPHCHC) synthase mutant, which is characterized in that on the basis of a bacillus subtilis SEPHCHC synthase gene MenD, 12 SEPHCHC synthase mutants are obtained by virtue of a site-specific mutagenesis PCR (Polymerase Chain Reaction) technology, and the SEPHCHC synthase gene MenD is used as a base. Recombinant bacteria of bacillus subtilis or bacillus natto or bacillus licheniformis or bacillus amyloliquefaciens for expressing the mutant are respectively constructed, and the yield of heptaene menadione fermented by the recombinant bacteria is 74%-203% of the yield of heptaene menadione fermented by the recombinant bacteria of bacillus subtilis for expressing wild type SEPHCHC synthase MenD.

The invention belongs to the technical field of chemical engineering, and relates to a method and a device for utilizing latent heat of a tower top gas phase in cyclohexanol preparation. Comprising a first separation tower, a second separation tower and the like, a tower top gas phase outlet of the second separation tower is connected with a hot side inlet of a second tower condenser, and a cold side outlet of the second tower condenser is connected with the first separation tower; a tower top gas phase outlet of the cyclohexene recovery tower is connected with the first separation tower; a tower top gas phase outlet of the cyclohexanol refining tower is connected with a hot side inlet of a refining tower condenser, and a cold side outlet of the refining tower condenser is connected with the second separation tower through a pipeline; an outlet of the hydration reaction system is connected with the first separation tower, and a tower kettle liquid phase outlet of the first separation tower is connected with an inlet of the second separation tower through a pipeline; a side line outlet of the first separation tower is connected with the hydration reaction system. The tower top gas phase latent heat of the second separation tower, the cyclohexene recovery tower and the cyclohexanol refining tower is recycled, so that the energy consumption in the cyclohexanol production process is reduced.

The invention discloses a preparation method of a pyridino-isoquinoline-2-ketone derivative, which comprises the following steps: under the protection of nitrogen, putting 1-aryl-3, 3-difluorocyclohexene, brominated N-(2-phenyl-2-oxo) ethyl isoquinolinium, alkali and a solvent into a reactor, reacting at 60 DEG C for a period of time, and then adding tert-butyl hydroperoxide to continue reacting; and after the reaction is finished, reducing pressure to remove the solvent, and carrying out column chromatography separation to obtain a pure product of the pyridino isoquinoline-2-ketone derivative. Initial raw materials are cheap, easy to obtain and wide in source, and products are complex and diversified in structure. The process flow is simple, and operation is simple and safe. Double bonds conjugated with two carbonyl groups in the target product can be further subjected to functionalization reaction, so that the target product can be conveniently subjected to diversified structural modification.

The invention relates to the technical field of power cables, and provides a high-toughness corrosion-resistant power cable which comprises a conductor, and an insulating layer, an armor layer and a sheath layer are sequentially arranged on the outer side of the conductor. The sheath layer comprises the following raw materials in parts by weight: 35-45 parts of polyethylene, 35-45 parts of methyl vinyl silicone rubber, 35-48 parts of nitrile rubber, 6-8 parts of a plasticizer, 20-30 parts of filler, 1-2 parts of an antioxidant, 1-2 parts of a vulcanizing agent and 10-13 parts of a functional aid; the functional additive is prepared from the following raw materials: zinc oxide, cinnamic acid and cyclohexenecarboxylic acid. According to the technical scheme, the problem of poor toughness of the sheath layer of the corrosion-resistant power cable in the prior art is solved.

The invention relates to the technical field of cyclohexene hydration and catalysts, and discloses a modified ZSM-5 molecular sieve and application thereof in cyclohexanol preparation through cyclohexene hydration. The modified ZSM-5 molecular sieve comprises a ZSM-5 molecular sieve inner core, the inner core is subjected to sulfonation treatment after broaching, and then the surface of the inner core is coated with SiO2 to form a core-shell structure; and carrying out hydrophobic modification on the ZrO2-SiO2 coated SO3H-ZSM-5 molecular sieve, and depositing a zirconium oxide layer on the surface of the ZrO2-SiO2 coated SO3H-ZSM-5 molecular sieve to obtain the ZrO2-SiO2 coated The molecular sieve is used as a catalyst in a cyclohexene hydration reaction, the conversion rate reaches 25% or above, the selectivity reaches 99.5% or above, the activity is still stable after the molecular sieve is recycled 6 times, the catalyst is excellent in catalytic performance, a new thought is provided for a current two-phase catalytic reaction, and meanwhile the molecular sieve is expected to be applied to a cyclohexene hydration industrial device.

The invention discloses a method for preparing adipic acid through electro-catalysis of cyclohexene. The method comprises the following steps: (I) carrying out electro-catalysis reduction on oxygen at a cathode to generate hydrogen peroxide; (2) reacting hydrogen peroxide with cyclohexene to obtain cyclohexanediol; (3) carrying out electrocatalytic oxidation reaction on cyclohexanediol at an anode to obtain adipate; and (IV) acidifying, washing and drying the adipate to obtain an adipic acid solid, and the like. According to the invention, the electrochemical reaction is driven by the electric power generated by renewable energy sources, so that the cascade reaction from cyclohexene to adipic acid is realized; the preparation method is mild in condition, green and environment-friendly and high in product selectivity, cathode oxygen reduction and anode cyclohexanediol oxidation are carried out by utilizing electric power generated by renewable energy sources, hydrogen peroxide generated by a cathode reacts with cyclohexene in a flowing system to generate cyclohexanediol, reaction liquid can be directly injected into an anode for reaction, and the yield is high. In the reaction process, only oxygen, dilute alkali solution and dilute acid solution are input except for cyclohexene, so that the use of strong acid and strong oxidant is avoided.

The invention discloses a novel compound 2-fluoropyridino-isoquinoline derivative as well as a preparation method and application thereof. The structural formula of the novel compound 2-fluoropyridino-isoquinoline derivative is as follows: # imgabs0 #, wherein Ar1 is phenyl, Ar2 is 3-chlorphenyl or Ar1 is 4-fluorophenyl, and Ar2 is phenyl; the preparation method comprises the following steps: reacting 1-aryl-3, 3-difluorocyclohexene, brominated N-(2-aryl-2-oxo) ethyl isoquinolinium, alkali and a solvent under the protection of nitrogen at the temperature of 60 DEG C; and after the reaction is finished, reducing pressure to remove the solvent, and performing column chromatography separation to obtain a pure product of the 2-fluoropyridinoisoquinoline derivative. The 2-fluoropyridinoisoquinoline derivative disclosed by the invention has better activity of inhibiting the growth of tumor cells, and has important guiding significance and application prospects for finding novel and efficient antitumor drugs.

The utility model provides a caprolactam rectification heat energy coupling utilization system, which comprises a cyclohexane refining tower, a cyclohexene separation tower and a debenzolization tower which are communicated in sequence, in the system, high-temperature gas-phase materials generated by the cyclohexane refining tower and the cyclohexene separation tower and kettle bottom liquid in the next tower are subjected to heat exchange treatment through a falling film evaporator, and the cyclohexene separation tower and the kettle bottom liquid in the next tower are separated; the feeding temperature of the next tower is increased, so that the heat utilization of high-temperature steam is improved, the use of steam is reduced, and the production cost is reduced; meanwhile, the use of fire coal is reduced, the emission of waste gas is reduced, and the environment is protected.

The invention belongs to the technical field of epoxy resin, and provides degradable epoxy resin containing a cyclic acetal structure and a preparation method and application thereof.The epoxy resin is based on alicyclic epoxy resin, the cyclic acetal structure is introduced into the alicyclic epoxy resin structure, the cyclic acetal structure has degradability under the acidic condition, and therefore the cyclic acetal structure can be degraded under the acidic condition; the rigidity of the annular structure is favorable for improving the mechanical property of the epoxy resin, and the finally obtained epoxy resin has the characteristics of good mechanical property, ultraviolet radiation resistance and suitability for the field of photocuring. According to the preparation method provided by the invention, 3-cyclohexene-1-formaldehyde and tetrahydric alcohol are taken as raw materials, and the epoxy resin is obtained through nucleophilic addition reaction and epoxidation reaction.

The invention discloses preparation of a lamellar Ti-MWW titanium silicalite molecular sieve and application of the lamellar Ti-MWW titanium silicalite molecular sieve in epoxidation reaction, and belongs to the technical field of synthesis of inorganic chemicals. According to the method, polycyclic aliphatic amines are added in the Ti-MWW molecular sieve synthesis process, the crystallization temperature is reduced in the initial crystallization stage of the molecular sieve to delay the growth speed of the C-axis of the molecular sieve, and the thin-layer Ti-MWW with the shorter C-axis is obtained, so that the diffusion performance of the Ti-MWW molecular sieve is greatly improved, the diffusion rate of reactant molecules in pore channels is increased, and the performance of the Ti-MWW molecular sieve is improved. Therefore, the catalytic performance of the molecular sieve is greatly improved, and the molecular sieve is suitable for catalyzing liquid-phase epoxidation reactions of propylene, butylene, hexene, cyclohexene and octene and the like.

The invention belongs to the technical field of cyclohexanol production, and particularly relates to a system and a method for improving the conversion rate of cyclohexanol prepared by cyclohexene hydration. The system for improving the conversion rate of cyclohexanol prepared by cyclohexene hydration comprises an alcohol tower I, a first hydration reactor and a second hydration reactor, a cyclohexene inlet and a side line extraction opening are respectively formed in the side wall of the alcohol tower I; the side line extraction port is communicated with an inlet of a first hydration reactor through a side line pipeline, a micro-interface reactor is arranged on the side line pipeline, a catalyst outlet is formed in the bottom of the first hydration reactor, and the catalyst outlet is communicated with a micro-interface mixing device through a catalyst pipeline; the first hydration reactor is communicated with the second hydration reactor through an overflow pipeline. According to the system and the method, on the premise of not changing the existing process operation, the reaction conversion rate of cyclohexanol prepared by a cyclohexene hydration method is improved, the process operation conditions are optimized, the energy consumption is reduced, and the purpose of improving the productivity is achieved.

The invention discloses a sandwich structure catalyst for preparing adipic acid through cyclohexene oxidation based on a metal organic framework material, and belongs to the technical field of chemical synthesis, the structure of the catalyst is as follows: magnetic iron oxide nanospheres are loaded with heteropolyacid nanodots, and the outer layer is coated with a porous metal organic framework shell. The catalyst has excellent magnetic recovery performance, large specific surface area and open pore channels, and has the advantages of high catalytic activity, easy recovery, stable structure and the like. The excellent performance shows that the sandwich structure catalyst has important application value in reactions for preparing adipic acid through cyclohexene oxidation and the like.

This invention relates to the field of organic synthesis technology and discloses a method for preparing 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester, comprising the steps of: S1, providing raw material: 3-cyclohexenecarboxylic acid-3′-cyclohexene methyl ester; S2, epoxidation reaction: mixing the raw material with hydrogen peroxide, a composite catalyst, and a buffer to obtain a reaction solution containing the target product; S3, separation and purification: allowing the reaction solution to stand and separate into layers, separating the organic phase, washing with water, drying, and vacuum distilling to obtain 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester. This method for preparing 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexylcarboxylic acid ester uses hydrogen peroxide as the oxygen source, resulting in no heavy metal pollution, low wastewater volume, and conforming to the trend of green chemistry. The composite catalyst requires a small amount, has high activity and good selectivity, can be recycled ≥5 times, reducing costs, requiring less equipment, and is highly safe. The product is colorless and transparent, with a high epoxy value, purity ≥98.5%, low acid value, and good stability.

The invention discloses a preparation method of tecovirimat and an intermediate thereof. The preparation method of the tecovirimat comprises the following steps: (i) cyclohexene 1 and chloroform react under the action of a catalyst M and an aqueous alkali solution to generate a compound 2; (ii) carrying out pyrolytic reaction on the compound 2 in a solvent A to generate cycloheptatriene 3; (iii) carrying out reaction on cycloheptatriene 3 and a compound 4 in a solvent B to obtain a compound 5; and (iv) carrying out amine condensation reaction on the compound 5 and a compound 6 in the presence of a solvent C to obtain tecovirimat. According to the preparation method, potential safety hazards caused by high-temperature reaction are avoided, side reactions are reduced, the yield and the product quality are improved, the process is stable, and the preparation method is suitable for large-scale production. # imgabs0 #

The invention provides a disease-resistant and growth-promoting aspergillus ochraceus AF-P9 and application thereof, and belongs to the technical field of microorganisms. The aspergillus ochraceus AF-P9 provided by the invention has salt resistance and alkali resistance, has the capabilities of producing siderophores and secreting chitinase, and has an efficient inhibition effect on a plurality of pathogenic bacteria such as fusarium oxysporum, fusarium oxysporum, fusarium tripteroides, pythium miscanthus, avena minuta, phomopsis divaricata, sclerotinia sclerotiorum, phytophthora and the like; the composition can be applied to prevention and treatment of rice damping-off. Furthermore, the metabolite of the aspergillus ochraceus AF-P9 is analyzed to obtain that the aspergillus ochraceus AF-P9 can generate a tricyclic cyclohexanone compound, a cyclohexene compound with a hydroxyl group, a phenanthrone-like compound with a hydroxyl group, a benzene ring compound with two long-chain esters, a cyclohexene compound with four parallel ring structures and the like. The aspergillus ochraceus AF-P9 provided by the invention provides a strain resource for biological prevention and control of diseases.

The present disclosure provides a pharmaceutical composition comprising (S)-1-(5-[2H,3H-[1,4]dioxyno[2,3-b]pyridin-7-sulfonyl]-1H,2H,3H,4H,5H,6H-pyrrolo[3,4-c]pyrrole-2-yl)-3-hydroxy-2-phenylpropan-1-one (“Compound 1”) in a crystalline solid form, a spray-drying dispersion, and a solid oral administration form, and a method for preparing the same.

The invention discloses a preparation method of a catalyst for preparing cyclohexene through benzene hydrogenation, and belongs to the technical field of catalyst preparation. Comprising the following steps: dropwise adding a metal salt solution containing ruthenium salt and zinc salt and a precipitant solution into an alcohol solution at the same time, and carrying out a co-precipitation reaction; carrying out in-situ reduction on a solid product obtained by the coprecipitation reaction; a product obtained after in-situ reduction is put into alkali liquor to be stirred; according to the method, the alcoholic solution is used as a coprecipitation reaction medium, does not participate in the reaction, but can adjust the microenvironment of the reaction medium, so that the microenvironment fluctuation of the solution in the precipitation process is relatively small; the catalyst with relatively uniform precipitation can be obtained, so that the activity of the prepared Ru-Zn catalyst can be improved; the problems of single precipitation process, insufficient catalyst structure uniformity, poor preparation reproducibility and the like of a traditional water phase coprecipitation method are solved; the catalyst is applied to a reaction for generating cyclohexene through selective hydrogenation of benzene.

The present invention relates to a visible-light-mediated one-step method for preparing phenol and cyclohexanone from cyclohexylbenzene (CHB). The method specifically comprises: under the irradiation of visible light, and with a hydrogen bromide solution as a catalyst and oxygen as an oxidizing agent, directly oxidizing cyclohexylbenzene in an organic solvent to break a carbon-carbon bond, so as to generate phenol and cyclohexanone. The method avoids such a process in a cyclohexylbenzene method in the prior art that cyclohexylbenzene needs to be first oxidized to obtain cyclohexylbenzene-1-hydroperoxide (1-CHBHP), then the mixture of the oxidation reaction products is treated, and then a cyclohexylbenzene peroxide is decomposed in an acidic condition to obtain phenol and cyclohexanone, and also avoids potential risks caused by the accumulation of peroxides. In addition, the method further has a great number of advantages of the operation being simple, reagents being easily available, reaction conditions being mild, easy control being achievable, the reaction being able to be scaled-up, a good selectivity being obtained, etc.

The present invention provides a catalyst, a preparation method thereof, and an application thereof in the liquid-phase alkylation of benzene and cyclohexene to synthesize cyclohexylbenzene. The catalyst uses MWW molecular sieve synthesized from inexpensive and low-toxic cyclohexylamine as the active component and silica as the binder. The prepared catalyst exhibits excellent catalytic performance in the liquid-phase alkylation reaction of benzene and cyclohexene.

The invention belongs to the field of application of cyclohexene hydration catalysts, and particularly relates to a method for improving cyclohexene hydration reaction efficiency. The method comprises the following steps: (1) weighing a catalyst, desalted water and a cosolvent, mixing, and uniformly stirring to obtain a mixed solution; (2) slowly pouring cyclohexene into the mixed solution, sealing, replacing with nitrogen, and reacting after the nitrogen is completely replaced; and after the reaction is finished, naturally cooling to room temperature, extracting by using a dichloromethane solution, and centrifuging. The method for improving the hydration reaction efficiency of cyclohexene provided by the invention can improve the conversion rate of cyclohexene and the yield of cyclohexanol, considers the feasibility of application on a device, and greatly reduces the dosage of a cosolvent, meets the actual operation condition of the device and improves the economic benefit under the condition of equal reaction efficiency compared with the prior art. The method can be widely applied to industrial production.

The present application discloses a molecular sieve, a preparation method thereof, and an application thereof in the liquid-phase alkylation reaction of benzene and cyclohexene. It at least includes the following steps: mixing raw materials containing a silicon source and an aluminum source with cyclohexylamine and water, crystallizing and calcining to obtain the molecular sieve. The MWW molecular sieve is synthesized by using cheap and low-toxic cyclohexylamine instead of highly toxic hexamethylenimine, making the synthesis process more green. The MWW molecular sieve synthesized by cyclohexylamine exhibits more excellent catalytic performance. The template agent can be removed during low-temperature calcination.

This invention relates to the field of adipic acid synthesis technology and discloses a method for producing adipic acid with low N2O tail gas emissions. The method includes: Step S1. A first contact reaction is carried out between cyclohexene, hydrogen peroxide, and a first catalyst, wherein the first catalyst is a solid catalyst comprising a tungsten-doped titanium-containing molecular sieve; the liquid phase material from the contact reaction is subjected to oil-water separation to obtain an aqueous phase containing cyclohexane oxide and an oil phase containing cyclohexene; Step S2. A second contact reaction is carried out between the aqueous phase containing cyclohexane oxide and nitric acid and a second catalyst, wherein the second catalyst is a Cu-containing... 2+ V 5+ and Mo 6+ The method utilizes ionic liquid catalysts. It results in low N2O emissions, high exhaust gas absorption rate, low production cost, and is environmentally friendly, showing promising prospects for industrial application.

The invention discloses a catalyst for preparing cyclohexylbenzene through alkylation of benzene and cyclohexene as well as a preparation method and application of the catalyst. The catalyst comprises an ultrathin layered MWW molecular sieve and heteropoly acid, and the layered thickness of the ultrathin layered MWW molecular sieve is 5-10 nm; the heteropoly acid is one or more of phosphotungstic acid, silicotungstic acid and phosphomolybdic acid. By adopting the catalyst, the selectivity can be improved, the service life of the catalyst can be prolonged, and the alkylation reaction of benzene and cyclohexene can be carried out at a lower reaction temperature, so that the selectivity of a key byproduct impurity methyl cyclopentylbenzene is reduced.

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein R1, R2, and R3 are defined herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.

The present application relates to the production field of organic chemical raw material cyclohexene, and discloses a production method of cyclohexene.The method comprises the following steps: carrying out cracking reaction on cyclohexylbenzene and / or dicyclohexylbenzene raw material and a solid acid catalyst to obtain cyclohexene and benzene; and the solid acid catalyst is selected from at least one of amorphous silicon aluminum, molecular sieve and solid supported inorganic acid.The method has the advantages of high raw material conversion rate, high cyclohexene yield and no by-product cyclohexane, etc.

The invention relates to a 2-succinyl-5-enol acetonyl-6-hydroxy-3-cyclohexene-1-carboxylic acid synthase mutant and application thereof, and belongs to the technical field of enzyme engineering. According to the invention, a key residue of 2-succinyl-5-enolacetonyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase is obtained by combining protein sequence comparison and alanine scanning strategies, the key residue is subjected to random mutation, and the menadione pathway resistant intermediate metabolite 1, 2, 3, 4-tetracarboxylic acid synthase is obtained through multiple rounds of screening. The mutant MenDW322IR323F which is subjected to feedback inhibition by using 2, 4-dihydroxy-2-naphthoic acid is synthesized, the heptaene menadione production capacity of the recombinant bacillus subtilis constructed according to the method is improved, the yield is 1.22 times that of a control strain, and the final yield reaches 186.5 mg / L. The invention not only provides a new direction for transformation of a menadione approach of bacillus subtilis, but also is beneficial to industrial expanded production of heptaene menadione.

This invention discloses a bicyclic [2.1.1]hexene compound and its preparation and application. The invention uses bicyclic [1.1.0]butanone and phosphate ester as starting materials, and potassium tert-butoxide tetrahydrofuran solution as base. The reaction is carried out under reflux at 80°C to obtain the bicyclic [2.1.1]hexene compound. The prepared compound has certain transpeptidase inhibitory activity and can effectively inhibit the infection and spread of Staphylococcus aureus.