The invention provides a manufacturing method of a high-strength anti-aging cable protection pipe. The manufacturing method comprises the following steps of a, stirring, wherein 100 parts of high-density polyethylene resin, 0.8-2.2 parts of an antioxidant, 1-4 parts of a lubricating agent, 0-40 parts of a filling agent, 6-20 parts of a plasticizer, 0.5-1.5 parts of a stabilizer and 4-8 parts of color masterbatch are weighed and placed into a stirrer for stirring treatment; b, drying, wherein a mixture is dried through a drying machine; c, extrusion and molding, wherein extrusion treatment of the mixture is carried out through an extruder, and the mixture enters a mold for molding treatment after extrusion; d, shaping, wherein shaping treatment of a semi-finished pipe is carried out; e, cooling, wherein the semi-finished pipe is cooled through cooling equipment; f, cutting, wherein the semi-finished pipe is cut through slitting equipment; g, polishing, wherein an end opening of the semi-finished pipe is polished through an end opening polishing device; h, spraying, wherein surface spraying treatment of the semi-finished pipe is carried out through a surface treatment device; and i,code spraying, wherein code spraying treatment of the semi-finished pipe is carried out through an automatic code spraying machine.