The invention discloses a preparation method of a magnesium-erbium-cerium fused fireproof profile, and relates to the technical field of fused fireproof profiles. The preparation method comprises following steps: weighing following raw materials: magnesia, erbium oxide, zirconia, and cerium oxide, wherein in the raw materials, magnesium accounts for 92.5 to 97 parts, erbium accounts for 1 to 3 parts, zirconium accounts for 0.5 to 1.5 parts, and cerium accounts for 1.5 to 3 parts; mixing and evenly stirring the raw materials in a mixing device; adding water, stirring to form a mixed material; drying the mixed material, adding the mixed material into an arc furnace at a time, fusing the mixed material, wherein during the fusion process, a microwave vibration mode is adopted, after the mixedmaterial is completely melted, taking out the electrodes, pouring the solution in the furnace into a profile grinding tool, and cooling. Cerium oxide and erbium oxide are added to improve the toughness and slag erosion resistant performance of the profile; one-time smelting and moulding is adopted, during the fusion process, a microwave vibration mode is adopted, the porosity of the profile is reduced, and the output and quality are both improved.