35 results about "N-iodosuccinimide" patented technology

The invention discloses a method for preparing 2,4-di-substituted-1,3,5-triazine. The method comprises the specific step: with substituted formamidine hydrochloride as a reaction substrate an iodine-containing compound as a catalyst, tert-butyl hydroperoxide as an oxidant, inorganic base as an acid binding agent and aliphatic ether as an organic solvent (also used as a carbon source), carrying outcarbon-hydrogen and carbon-oxygen bond deletion, nucleophilic addition, deaminizing condensation and oxidative aromatization reaction to obtain a 2,4-di-substituted-1,3,5-triazine compound, wherein achemical structural general formula of the substituted formamidine hydrochloride is shown in the description; the iodine-containing compound is selected from one of potassium iodide (KI), tetrabutylammonium iodide (TBAI), elemental iodine (I2) and N-iodosuccinimide (NIS); the inorganic base is selected from one of anhydrous potassium carbonate, anhydrous sodium carbonate, cesium carbonate, potassium hydroxide and potassium tert-butoxide; and the aliphatic ether is selected from one of methyl tert-butyl ether, ethyl ether and ethylene glycol dimethyl ether. The preparation method disclosed bythe invention has the characteristics of easily-obtained raw materials, low price and low toxicity of a catalyst, wide range of the substrate, simplicity and convenience in operation, greenness, environmental protection and the like.

The invention belongs to the technical field of organic chemistry and pharmaceutical chemistry, and in particular relates to a method for stereoselective preparation of derivatives of pyrane. The method comprises the following steps of: under the protection of inert gases, adding derivatives of 1-p-tolylthio-2-C-glyoxyl-alpha-D-glucopyranose, derivatives of 1-thiophenyl-2-C- glyoxyl-alpha-D-glucopyranose or derivatives of 1-ethylthio p-tolyl-2-C-glyoxyl-alpha-D-glucopyranose, which serve as reactants, into a reactor, adding alcohol, phenol, trimethylsilyl azide or monosaccharide derivatives, adding a solvent such as methylene chloride to dissolve the raw materials, and performing the reaction at the reaction temperature of between 40 DEG C below zero and room temperature in the presence of a catalyst which is N-iodosuccinimide, or N-bromosuccinimide, or copper bromide and tetrabutylammonium bromide, or iodine, bromine simple substance or N-iodosuccinimide and trimethylsilyl triflate, or trifluoromethanesulfonic silver, or paratoluenesulfonic acid or trifluoromethanesulfonic acid to obtain the derivatives of pyrane. The method has the advantages of simple operation, high selectivity, low cost, light environmental pollution and the like.

Provided are a 4-cyano-5-(3-indolyl) oxazole compound and a preparation method thereof. 3- (1H-indole-3-group)-3-oxy propionitrile and benzylamine are used as raw materials, and 5-(3-indole) oxazole is a heterocyclic skeleton. The formula is as shown in the description, wherein R1 is hydrogen, methyl, ethyl, tertiary butyl, tertiary butyl oxy carbonyl or benzyl, R2 is halogen, ester, carboxyl, cyano, amino or methoxy; benzylamine Ar is alkyl or alkoxy-substituted aromatic hydrocarbon, halogenated aromatics or heteroaromatic aromatics, iodisan is one of iodine, potassium iodide, sodium iodide,tetrabutyl ammonium iodide, sulfonium iodate salt, cesium iodide and N-Iodosuccinimide, oxidizing agent is one of hydrogen peroxide, peroxy tert butyl alcohol, potassium hydrogen persulfate, ditert butyl peroxide and chloramine salt, and solvent is one or two of ethyl acetate, acetonitrile, N, N-dimethylformamide, diethyl ether, dimethyl sulfoxide, 1,2-dichloroethane, methyl alcohol, ethyl alcohol, isopropanol, n-butyl ether, n-butyl alcohol, benzene, methylbenzene, 1,4-dioxane, methyl tert-butyl ether, dichloromethane, cyclohexane, petroleum ether, carbon tetrachloride, trichloromethane and tetrahydrofuran.