This invention relates to an
RNA liquid formulation comprising: (a) at least one
RNA composition comprising at least one isolated
RNA molecule and a silica carrier, and (b) an
adjuvant selected from (A), (B), and (C): (A) having the general formula (I)M j D k T l The polyglycerol ester, wherein M is [C3H5(OR'')2O 1 / 2 D is [C3H5(OR'')1O] 2 / 2 T is [C3H5O] 3 / 2 ], j=1 to 10, preferably 2 to 3, more preferably 2; k=0 to 10, preferably greater than 0 to 5, more preferably 1 to 3; l=0 to 3, preferably 0 to 1, more preferably 0; wherein, the sum of j+k+l is 1 to 20, preferably 2 to 4, more preferably 3, wherein each group R'' is independently selected from acyl groups R'-C(=O)- and H, provided that at least one group R'' is not equal to H; wherein each group R' is independently selected from monovalent aliphatic, saturated or
unsaturated hydrocarbon groups having 3 to 39, preferably 7 to 21, more preferably 9 to 17 carbon atoms; (B) Formula (II)M 1 o D 1 p D' q Among the polyether-modified siloxanes, M 1 It is P 1 3SiO 1 / 2 D 1 It is P 1 2SiO 2 / 2 D' is P 1 P 2 SiO 2 / 2 o is 2, p is between 0 and 0.1, q is between 1.0 and 1.15, P 1 Independently, it is a
hydrocarbon group having 1 to 8 carbon atoms, P 2 Independently for equation (III)—P 3 O[CH2CH2O] m [CH2CH(CH3)O] n P 5 The polyether groups have m
ranging from 3.4 to 11.0 and n
ranging from 2.5 to 8.0, and the condition is that m / n is 1.9 to 2.8, P 3 Independently, it is a
divalent hydrocarbon group having 2 to 8 carbon atoms, P 5The form is
hydrogen; and (C) is an organic modified polysiloxane of formula (IV) where a+b+c+d+2=20 to 210, a is 15 to 205, b is 1 to 12, c is 1 to 12, d is 1 to 12, R groups are each independently the same or different aliphatic or
aromatic hydrocarbon groups having 1 to 10 carbon atoms, R4 groups are each independently the same or different R, R1, R2 or R3 groups, R1, R2 and R3 groups are each independently different polyether groups of general formula (V) where e is 3 to 11, f is 6 to 30, g is 0 to 15, h is 0 to 5, i is 0 to 6, and R5 are independently the same or different, and each is a methyl, acetyl or
hydrogen group.