The present invention discloses a plasma protein powder free weaned piglet milk replacer. The milk replacer consists of the following proportioned raw materials in parts by weight: ordinary corn 9.1 parts, extruded corn 5 parts, rice 12.5 parts, shortening 1 part, extruded soybean 12.5 parts, soybean meal 8 parts, soybean oil 1 part, white granulated sugar 3 parts, fish meal 4.5 parts, calcium hydrogen phosphate 0.4 part, stone powder 0.5 part, lysine 0.45 part, methionine 0.05 part, threonine 0.15 part, tryptophan 0.05 part, choline 0.15 part, monosodium glutamate 0.2 part, cupric sulfate 0.06 part, trace mineral elements 0.2 part, yolk antibody 0.105 part, acidifier 0.5 part, mildew-proof agent 0.1 part, antioxidant 0.04 part, maltodextrin 10 parts, trace vitamins 0.4 part, flour 12.65 parts, enzymic preparation 0.13 part, glucose 5 parts, intestinal membrane protein powder 3 parts, composite yeast 1.5 parts, whey powder 7.5 parts, flavouring agent 0.1 part, sweetener 0.05 part and micro ecological preparation 0.03 part. The milk replacer avoids the risk of homologous biological safety.