The invention belongs to the technical field of nano materials, and particularly relates to a method and equipment for stripping a layered material nanosheet, and the method comprises the following steps: S1, taking out a layered crystal material, mixing the layered crystal material with a liquid phase medium, putting the mixture into wet grinding equipment for wet grinding, and obtaining a wet grinding mixture after wet grinding; S2, placing a wet grinding mixture obtained after wet grinding in the step S1 in vibration equipment to be vibrated, and achieving sufficient mixing; and S3, addingthe wet grinding mixture obtained by fully mixing in the step S2 and an organic solvent into high-pressure heating equipment, and performing stripping to obtain a suspension solution formed by the nanosheet and the organic solvent and unstripped crystal powder. According to the invention, the wet grinding mixture can be fully mixed, the stripping efficiency can be improved, the stripping time is short, the yield is high, ultrasonic-assisted stripping is not needed, nanosheet size reduction and nanosheet structure defects are avoided, high universality is achieved, the method and the equipmentfor stripping a layered material nanosheet are suitable for large-scale production, the total production efficiency is effectively improved, and the production cost is reduced.