The invention relates to preparation method of a nano multifunctional paint additive. The nano multifunctional paint additive is characterized in that a composition consists of nano zinc dioxide, 2-hydroxy-4-methoxy diphenyl ketone, silver-loaded nano zirconium phosphate, dimethyl benzyl dodecyl ammonium bromide, auxiliary materials and water. The composition contains nano zinc dioxide as well as 2-hydroxy-4-methoxy diphenyl ketone, so that ultraviolet rays can be absorbed to achieve antioxidation and preventing paint resin from being quickly pulverized; the siliver-loaded nano zirconium phosphate can achieve antibacterial action; the dimethyl benzyl dodecyl ammonium bromide can achieve mildew-proof action. and therefore, the nano multifunctional paint additive has effects of preventing mildew, preventing corrosion, sterilizing, preventing oxidization, absorbing ultraviolet rays, and the like, and can be applied to developing emulsion paint, water-borne pigment and water-borne interior and exterior wall paint. Dosage of the nano multifunctional paint additive disclosed by the invention is 0.1%-0.3% of the paint, paint mildew-proof efficiency reaches 99.1% and the sterilizing efficiency reaches 99.6%.