The invention discloses a high-strength and high-plasticity hollow aluminum profile and a preparation method thereof, and belongs to the field of aluminum profile preparation. The high-strength and high-plasticity hollow aluminum profile comprises the following raw materials of, in percentage by weight (wt%), 2.0-4.0 of Mg, 2.0-4.0 of Cu, 0.4-0.8 of Si, 0.4-1.0 of Gu, 0.8-1.0 of As, 0.2-0.6 of Ti,0.4-1.0 of Mn, 1.0-3.0 of Fe, 0.4-0.6 of Cr, 0.4-0.6 of Zn, 0.6-0.8 of Li, and the balance aluminum and inevitable impurities. By controlling the content of elements in aluminum alloy components, strengthening phases such as Al2Cu, Al2CuMg, Mg2Si and MgZn2 are formed in an aluminum alloy, the strengthening phases act synergistically, so that the effects of deoxidizing and refining grains are achieved, the obvious strengthening effect on the aluminum profile is achieved, the cracking sensitivity of a material is effectively reduced, the mechanical properties such as plasticity, toughness and fatigue resistance of the aluminum profile and the good machining performance are improved, and the performance requirement of the aluminum profile for alternate transportation can be met.