61 results about "Methoxymethylbenzene" patented technology

An oxidative hair colorant composition to be dispensed from a manually-actuable, non-aerosol dispenser as a foam. The oxidative hair colorant composition contains the free-base of 1,4-diamino-2-methoxymethyl benzene to achieve for efficient dye precursor levels in formulation and to achieve a desire rheology profile of the oxidative hair colorant composition.

The invention discloses a supported nickel-cobalt bimetallic nano-catalyst and an application of the supported nickel-cobalt bimetallic nano-catalyst in catalyzing a selective hydrogenation reaction of vanillin. On the basis of a special pore channel structure of MOF, nickel is introduced for structural modulation, then metal is reduced at a high temperature by using a carbon source of the MOF to form a carbon-loaded and coated metal structure, and the alloy is coated with a carbon layer by further combining with glucose carbonization, so that the bimetallic nickel-cobalt alloy nano-catalyst with a double-carbon-layer protection structure is constructed; and the structure can prevent oxidation and dissolution of metal particles, and the stability of the catalyst is greatly improved. The prepared bimetallic nickel-cobalt alloy nano-catalyst is novel and unique in structure, high in stability and high in catalytic activity; and when the bimetallic nickel-cobalt alloy nano-catalyst is applied to a reaction for preparing 2-methoxy-4-methylphenol through selective hydrogenation of vanillin, the conversion rate of vanillin reaches 90-100%, and the selectivity of 2-methoxy-4-methylphenol reaches 90-100%.

The invention provides a minjiang lily spice composite as a new-type lily spice composite which is characterized in that: at least one of jasmal, geranyl acetate, terpene-4-ethanol, dimethoxy methyl benzol, methyl anthranilate and anisyl acetate is added in a base composite based on the lily spice, further comprising at least one spice regulator of triethyl citrate, diisobutyl adipate, tetrahydrophthalic anhydride abietic acid methyl ester and Dihydrogenated abietic acid methyl ester.

The invention relates to a process for preparing 2,3-dimethoxy-5- methyl-1,4- benzophenone (I) by subjecting raw material 3,4,5-trimethoxytoluene (II) first with phosphorus oxytrichloride and N,N-dimethyl formamide to Vilsmeier reaction, obtaining 2,3,4-trimethoxyl-6- methyl- benzaldehyde (III) by introducing aldehydo onto phenyl ring, and oxidizing (III) into phenol (IV) with H2O2 at the presence of small amount organic acid catalysis at room temperate.

The invention relates to a medicinal composition for inhibiting angiogenesis and application thereof. The medicinal composition comprises any one composition of 2-methoxy-6-methyl-P-benzoquinone(2-methoxy-6-methyl-p-benzoquinone), 2,3-dimethoxy-5-methyl-P-benzoquinone(2,3-dimethoxy-5-methyl-p-benzoquinone) or 2-hydroxy-5-methoxy-3-methyl-P-benzoquinone(2-hydroxy-5-methoxy-3-methyl-p-benzoquinone) and appropriate pharmaceutically acceptable excipients or supporting agents; and the medicinal composition is used for inhibiting the angiogenesis and further treats or prevents angiogenesis-related diseases.

The invention relates to a Si-H polymer, a heat-conducting silica gel composition and a preparation method and application of the Si-H polymer and the heat-conducting silica gel composition. The Si-H polymer is obtained by carrying out condensation polymerization on hydrogen-containing silane containing 2 to 3 methoxy groups, methyl phenyl diethoxy silane and diphenyl silanediol; the molar ratio of the methoxy group in the hydrogen-containing silane to the diethoxy group in the methyl phenyl diethoxy silane to the hydroxyl group in the diphenyl silanediol is 1: (0.5-1.5): (0.25-1). The Si-H polymer is used as a cross-linking agent to be added into the components of the heat-conducting silica gel, so that the oil leakage problem of the cured heat-conducting silica gel can be effectively improved, and meanwhile, no obvious negative influence is brought to the flexibility of the heat-conducting silica gel. In addition, the oil leakage problem is effectively improved, so that the heat-conducting property of the heat-conducting silica gel is kept stable for a long time.

The invention discloses a synthesis method of DPA. The method comprises the following steps: (1) adding methanol, o-nitrotoluene, a catalyst, concentrated sulfuric acid, distilled water into an autoclave, performing heating with stirring to 50 DEG C, evacuating air and then introducing hydrogen, controlling a pressure in the autoclave to 0.1 MPa, carrying out a reaction for 5 h, then performing suction filtration, distilling a filtrate to remove methanol, diluting a residual solution by adding water and then adjusting pH to be neutral with ammonia water, performing extracting with toluene, washing an organic phase with a dilute sodium hydroxide solution, and performing reduced pressure distillation on the organic phase to obtain 4-methoxy-2-methylaniline; and (2) adding 4-methoxy-2-methylaniline, phenol naphthalene, cyclohexanone, and the catalyst into an autoclave, replacing air with nitrogen, performing heating to 250 DEG C, controlling a pressure in the autoclave to 1 Mpa, performing cooling to room temperature after a reaction is completed, filtering a reaction solution, and performing reduced pressure distillation on a filtrate and collecting various fractions, wherein a latter fraction is DPA. The raw materials are cheap and easy to obtain, the operation is simple, the yield is high, the energy consumption is low, and the method has practical value and economic value, andis suitable for enterprise production.

By reacting 3-methyl-2-methoxymethylaniline, etc. with a phosgene compound in the presence of a tertiary amine at 10° C. to 14° C. in at least one kind of solvent selected from a group consisting of chlorobenzene and ortho-dichlorobenzene, an isocyanate compound such as 3-methyl-2-methoxymethyl-1-isocyanatobenzene can be manufactured with good yields.

The invention discloses a purifying method of N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine. The purifying method comprises the steps as follows: adding water and acid to reaction product obtained by reaction of 3-methoxy-2-methyl benzoyl chloride and tert-butylhydrazine to carry out acidizing until pH is less than 3; keeping the hydrolysis temperature of 40 to 105 DEG C, and hydrolyzing for 0.5 to 5 hours for hydrolyzing the byproduct; filtering to remove 3-methoxy-2-methyl benzoic acid; adding alkali to the obtained mother liquor to carry out alkalizing; adjusting pH to 7 to 12; and filtering to obtain the high-purity product N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine. The purifying method disclosed by the invention is simple in production, and greatly improves the purity of the product; and moreover, the expensive intermediate 3-methoxy-2-methyl benzoic acid can be recycled, so that the producing cost is reduced; and little three wastes are produced during the processing; and the purifying method is beneficial to environmental protection, and is suitable for industrial production.

The invention provides a method for preparing 2-methoxy-4-methylphenol from biomass-based vanillin and a preparation method of the 2-methoxy-4-methylphenol. According to the method, vanillin, a catalyst and a solvent are added into a reaction kettle, chemical reaction is carried out in the reaction kettle to obtain the required 2-methoxy-4-methylphenol, the catalyst is a nitrogen-doped hollow carbon sphere loaded non-noble metal Co catalyst, the main structure of the catalyst is a hollow carbon sphere, the hollow structure is used as a carrier, and the carrier is used as a solvent. Metal particles are loaded on the carrier, and the surface of the carrier has a mesoporous structure, so that a unique confinement effect can be provided for hydrodeoxygenation reaction of vanillin, the metal nanoparticles can be stabilized, the stability of the catalyst can be improved, meanwhile, strong metal-carrier interaction can be formed, and the electronic property of the metal surface can be effectively changed; furthermore, adsorption and activation of vanillin and an intermediate vanillyl alcohol on the surface of the catalyst can be enhanced, and the selectivity of preparing 2-methoxy-4-methylphenol by hydrodeoxygenation of vanillin is improved.

The invention discloses a salt-fog-resistant silver-plated aluminum powder conductive coating and a preparation method thereof, and belongs to the technical field of conductive coating preparation. Aluminum powder is placed in a 2-methoxy-4-methylphenol aqueous solution for a surface modification reaction, a modified product is washed and then dried, and reduced aluminum powder with the surface coated with a reduction layer is prepared; the obtained reduced aluminum powder is subjected to surface activity treatment washing through a silver source, and activated aluminum powder with elemental silver on the surface is obtained after an active product is washed; the obtained activated aluminum powder is subjected to chemical silver plating treatment, and silver-plated aluminum powder is prepared; graft modification is conducted on the silver-plated aluminum powder by adopting perfluorodecanethiol to obtain a grafted product, and the obtained grafted product is washed and dried to obtain modified silver-plated aluminum powder; and the obtained modified silver-plated aluminum powder is sprayed on a coating substrate to obtain a coating, and the obtained coating is dried to obtain the salt-fog-resistant silver-plated aluminum powder conductive coating. The preparation method is simple to operate and low in cost, and the obtained product is excellent in salt spray corrosion resistance and has expanded-scale production value.

The invention discloses a synthesis process of 2-methyl-3-methoxybenzoic acid, which comprises the following steps: (1) reductive hydrogenation reaction: by taking 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitrobenzoate as a raw material, methanol as a solvent, hydrogen as a hydrogen source and palladium on carbon or platinum on carbon as a catalyst, carrying out hydrogenation reduction to prepare 3-amino-2-methyl benzoic acid or methyl 3-amino-2-methyl benzoate; (2) diazotization, hydrolysis and esterification one-pot reaction: by taking the reduction product as a raw material and methanol as a solvent, under the action of a diazotization reagent, performing diazotization, hydrolysis and esterification reaction to prepare methyl 3-hydroxy-2-methyl benzoate; (3) methylation reaction: by taking methyl 3-hydroxy-2-methyl benzoate as a raw material and dimethyl sulfate as a methylation reagent, carrying out methylation reaction in the presence of alkali to prepare methyl 3-methoxy-2-methyl benzoate; and (4) hydrolysis reaction: mixing the methyl 3-methoxy-2-methyl benzoate with alkali and water, conducting heating for hydrolysis, conducting cooling after the reaction is completed, adjusting the pH value to 1-3 by using acid, separating out a product, conducting filtering, and conducting drying to obtain 3-methoxy-2-methyl benzoic acid.

The invention provides a preparation method of a key intermediate compound 1-(2-halogeno)-2-methyl-butanone-1 for the synthesis of an oral antidiabetic medicament Repaglinide, belonging to the field of organic chemical synthesis. The preparation method comprises the following steps: under the action of phosphorus trichloride, preparing 2-halogenobenzoic acid and N-methoxy methylamine used as raw materials into 2-halogeno-N-methoxy-N-methyl benzamide in anhydrous methylbenzene used as solvent; and then, further reacting with magnesium isobutyl bromide under the protection of nitrogen gas for 2-3 hours, separating, and purifying to obtain the target compound 1-(2-halogenophenyl)-3-methyl-butanone-1. The preparation method provided by the invention has the advantages of accessible raw materials, simple process, short reaction scheme, low cost and high efficiency; the reaction is performed at room temperature, the reaction conditions are mild, no catalyst is used, and few subsidiary reaction exists in the reaction, thereby ensuring that the preparation method is green and environment-friendly; and the target product yield is high (up to 80% or above), and the product quality is high (the purity is above 99%). Thus, the preparation method is beneficial to industrial production.