63 results about "Methoxymethylbenzene" patented technology

An oxidative hair colorant composition to be dispensed from a manually-actuable, non-aerosol dispenser as a foam. The oxidative hair colorant composition contains the free-base of 1,4-diamino-2-methoxymethyl benzene to achieve for efficient dye precursor levels in formulation and to achieve a desire rheology profile of the oxidative hair colorant composition.

The invention provides a preparation method for tefuryltrione, and belongs to the technical field of compound preparation. The preparation method comprises the following steps that esterification reaction is carried out on 2-chloro-3-methyl-4-methylsulfonylbenzoic acid serving as a raw material and methanol so as to generate methyl 2-chloro-3-methyl-4- methanesulfonylbenzoate; then reaction is carried out with N-bromosuccinimide to replace one hydrogen in a methyl group on a benzene ring so as to generate methyl 2-chloro-3-methyl bromide-4-methanesulfonylbenzoate; then a product of methyl 2-chloro-4-(methylsulfonyl)-3-(((tetrahydrofuran-2-yl)methoxy)methyl) benzoate is synthesized by using a Williamson synthesis method; and then condensation reaction is carried out with cyclohexanedione under the action of ethylene diamine so as to generate enol ester, and finally, acetonitrile is added for rearrangement catalysis under the action of the ethylene diamine so as to obtain a target product of the tefuryltrione. The preparation method has the advantages of being mild in reaction conditions and simple in synthesis steps.

The invention discloses a method for synthesizing 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol through 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene and belongs to the technical field of organic synthesis. The method comprises the following steps: taking the 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene to react in a mixed solution composed of a sulfuric acid water solution and organiccarboxylic acid; carrying out ester group hydrolysis reaction on an obtained mixture under the action of inorganic alkali; carrying out methylation reaction of hydroxyl under the action of the inorganic alkali; finally, separating and purifying to obtain the 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol and recycling the 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene. According to the method provided by the invention, resource utilization of the low-value 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene is realized; meanwhile, the method has the advantages of cheap and easy-to-obtain reaction reagents, moderate reaction conditions, simplicity in operation, high synthesis yield, good product quality and the like, and has very high social and economic value.

The invention relates to a preparation method for idebenone, comprising the following steps: (1), 3,4,5-trimethoxy-toluene has friedel-crafts reaction with 10-acetoxy-decane chloride or 10-acetoxy-decanoyl- bromine to generate 6-(10-acetoxy-1-oxo-decane yl)-2,3-dimethoxy-5-methyl phenol; (2), the 6-(10-acetoxy-1-oxo-decane yl)-2,3-dimethoxy-5-methyl phenol obtained in the step (1) is reacted withhydrogen under the joint effect of palladium-carbon catalyst and dehydrating agent DCC to generate 6-(10-acetoxy-decyl)-2,3-dimethoxy-5-methyl phenol; (3), the6-(10-acetoxy-decyl)-2,3-dimethoxy-5-methyl phenol prepares 6-(10-hydroxy decyl) -2,3-dimethoxy-5-methyl phenol through hydrolysis; (4), the 6-(10-hydroxy decyl) -2,3-dimethoxy-5-methyl phenol has oxidation reaction with an oxygen-supply body under the effect of catalytic oxidizer Cu (Salen) so as to generate the idebenone. The preparation method has low cost and high yield, which is suitable for large-scale industrial idebenone production.

The invention discloses a purifying method of N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine. The purifying method comprises the steps as follows: adding water and acid to reaction product obtained by reaction of 3-methoxy-2-methyl benzoyl chloride and tert-butylhydrazine to carry out acidizing until pH is less than 3; keeping the hydrolysis temperature of 40 to 105 DEG C, and hydrolyzing for 0.5 to 5 hours for hydrolyzing the byproduct; filtering to remove 3-methoxy-2-methyl benzoic acid; adding alkali to the obtained mother liquor to carry out alkalizing; adjusting pH to 7 to 12; and filtering to obtain the high-purity product N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine. The purifying method disclosed by the invention is simple in production, and greatly improves the purity of the product; and moreover, the expensive intermediate 3-methoxy-2-methyl benzoic acid can be recycled, so that the producing cost is reduced; and little three wastes are produced during the processing; and the purifying method is beneficial to environmental protection, and is suitable for industrial production.

A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely 2-methoxymethylaniline.

The invention provides a preparation method of a key intermediate compound 1-(2-halogeno)-2-methyl-butanone-1 for the synthesis of an oral antidiabetic medicament Repaglinide, belonging to the field of organic chemical synthesis. The preparation method comprises the following steps: under the action of phosphorus trichloride, preparing 2-halogenobenzoic acid and N-methoxy methylamine used as raw materials into 2-halogeno-N-methoxy-N-methyl benzamide in anhydrous methylbenzene used as solvent; and then, further reacting with magnesium isobutyl bromide under the protection of nitrogen gas for 2-3 hours, separating, and purifying to obtain the target compound 1-(2-halogenophenyl)-3-methyl-butanone-1. The preparation method provided by the invention has the advantages of accessible raw materials, simple process, short reaction scheme, low cost and high efficiency; the reaction is performed at room temperature, the reaction conditions are mild, no catalyst is used, and few subsidiary reaction exists in the reaction, thereby ensuring that the preparation method is green and environment-friendly; and the target product yield is high (up to 80% or above), and the product quality is high (the purity is above 99%). Thus, the preparation method is beneficial to industrial production.