23 results about "Methoxymethylbenzene" patented technology

Described herein are pharmaceutical formulations of a farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, and methods of using such pharmaceutical formulations in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Described herein is the farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts, solvates, and formulations thereof.

This article describes pharmaceutical formulations of the farnesol X receptor agonist 3-hydroxyazacyclobutane-trans-1-carboxylic acid 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octane-1-yl)methyl)carbamoyl)cyclohexyl ester, and methods of using such pharmaceutical formulations to treat conditions, diseases, or symptoms associated with farnesol X receptor activity.

The invention is applicable to the technical field of biomass energy catalysis and conversion, and provides a high-activity and high-stability nickel-cobalt alloy catalyst and a synthesis method and application thereof, and the synthesis method comprises the following steps: preparing S-1 zeolite; the preparation method comprises the following steps: mixing S-1 zeolite with an aqueous solution of Ni (NO3) 2.6 H2O and an aqueous solution of Co (NO3) 2.6 H2O for dipping, placing the mixture in a tetrapropylammonium hydroxide solution for hydro-thermal treatment, and performing static calcination to obtain a NixCoyO at S-1 nanocrystal; mixing the NixCoyO (at) S-1 nanocrystal with polymers P123, F127, dopamine hydrochloride and 1, 3, 5-trimethylbenzene, performing ultrasonic dispersion in a mixed solvent of water and ethanol, adding ammonia water for reaction, and collecting NixCoyO (at) S-1 (at) mPDA; and carrying out carbonization and reduction on the NixCoyO (at) S-1 (at) mPDA to obtain the NixCoy (at) S-1 (at) mC catalyst. The prepared catalyst has excellent hydrodeoxygenation performance, vanillin can be efficiently converted into 2-methoxy-4-methylphenol (MMP) under mild conditions, and the yield exceeds 94%.

The invention belongs to the technical field of structural bonding, and particularly relates to a preparation method of epoxy modified silicone oil and application of the epoxy modified silicone oil in a temperature-resistant structural adhesive. According to the invention, gamma-glycidyl ether oxypropyl methyl dimethoxy silane, dimethoxy (methyl) phenyl silane and hexamethyl dimethoxy silane are used as raw materials to prepare methyl phenyl epoxy modified silicone oil (Ph-EpSO), and the methyl phenyl epoxy modified silicone oil (Ph-EpSO), 170 type epoxy resin, a dicyandiamide curing agent and an auxiliary agent are used to prepare the temperature-resistant structural adhesive (TRSA). By optimizing the ratio of the epoxy group to the phenyl group in the synthesized methyl phenyl epoxy modified silicone oil, the temperature-resistant structural adhesive does not crack after being subjected to cold and hot impact at the temperature of 40-140 DEG C for 24 rounds, and meanwhile, the bending part does not have cracking and whitening phenomena; the direct current breakdown voltage and the alternating current breakdown voltage at the bending part after 24 rounds of hot and cold shock are 4.21 kV and 3.05 kV respectively; the shearing force is 6.091 Mpa, and the adhesive has relatively good temperature resistance, pressure resistance and adhesive property.

The present invention relates to formulations of farnesol X receptor agonists. Specifically, described herein are pharmaceutical formulations of the farnesoid X receptor agonist 3-hydroxyazetidine-trans-1-carboxylic acid 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl) pyridin-2-yl) ((4-(4-methoxy-3-methylphenyl) bicyclo [2.2. 2] octane-1-yl) methyl) carbamoyl) cyclohexyl, and methods for preparing the pharmaceutical formulations of the farnesoid X receptor agonist 3-hydroxyazetidine-trans-1-carboxylic acid. And methods of treating conditions, diseases, or conditions associated with farnesoid X receptor activity using such pharmaceutical formulations.

The application discloses a preparation method and application of a three-dimensional hierarchical ordered mesoporous zeolite limited NiCo alloy catalyst, and belongs to the technical field of lignin model compound catalytic upgrading. The catalyst forms a bimetallic active component by using metal Ni and Co, and forms a coating limitation for the active component in the process of synthesizing three-dimensional hierarchical ordered mesoporous 3DZSM-5 zeolite, so that the prepared catalyst has small metal particle size and high dispersity. The existence of the three-dimensional hierarchical ordered mesopore is beneficial to the contact, diffusion and transfer of reactants in the pore. The catalyst prepared by the application is used for preparing 2-methoxy-4-methylphenol by carrying out vanillin hydrodeoxygenation, and excellent catalytic performance is exhibited. In the recycling process of the catalyst, there is almost no metal leaching, subsequent separation is simple, cost is low, and the catalyst is beneficial to industrial production.

To provide pharmaceutical formulations and methods of use thereof in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.SOLUTION: Pharmaceutical formulations of a farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, and methods of using such pharmaceutical formulations in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity are disclosed.SELECTED DRAWING: Figure 1

The present application relates to a kind of preparation method of furan sulfonyl ketone and its intermediate, with 2-chloro-3-methyl-4-methylsulfonyl benzoic acid as raw material, directly bromination is obtained 2-chloro-3-bromomethyl-4-methylsulfonyl benzoic acid;Then 2-chloro-3-bromomethyl-4-methylsulfonyl benzoic acid and tetrahydrofurfuryl alcohol substitution reaction is obtained 2-chloro-4-(methylsulfonyl)-3-(((tetrahydrofuran-2-yl) methoxy) methyl) benzoic acid;Then intermediate acyl chloride is formed;Acyl chloride intermediate and cyclohexanedione are condensed under the action of triethylamine, finally catalyst acetone cyanohydrin is added and rearrangement reaction is obtained target product furan sulfonyl ketone.Compared with prior art, the present application reduces the esterification protection of raw material 2-chloro-3-methyl-4-methylsulfonyl benzoic acid in the step of preparing furan sulfonyl ketone and the deprotection step in subsequent step, and the bromide removed in the reaction can be recycled and reused, shorten the reaction step, improve the overall yield, more green and environmental protection.

The invention discloses a synthesis method of a diene liquid crystal monomer, which comprises the following steps: S1, Grignard addition reaction: carrying out Grignard addition reaction on substituted cyclohexyl N-methoxy-N-methyl benzamide and a substituted cyclohexyl methyl chloride Grignard reagent to obtain a ketone intermediate; s2, the ketone intermediate sequentially reacts with 5, 5-dibromobarbituric acid for a bromination reaction, then sodium formate is added into an alcohol solvent for a hydroxylation reaction, then sodium borohydride is added for a reduction reaction, and a vicinal diol intermediate is obtained; and S3, carrying out an orthoformate reaction on the vicinal diol intermediate obtained in the step S2 and triethyl orthoformate in a fluorine-containing alcohol solvent, then heating to reflux, and carrying out an elimination reaction to obtain the target diene liquid crystal monomer. According to the invention, a traditional double bond construction strategy of multiple Wittig reactions is abandoned, a new synthesis route which takes the Grignard reaction as a starting point and finally constructs a diene structure by a one-pot method through a low-temperature orthoformate / elimination reaction carried out in a specific fluorine-containing solvent is designed, the route is simple, the total yield is high, and the overall cost is lower.

The present invention relates to an improved process for the preparation of phenyl-substituted 3- difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-2-phenyl-ethyl]-amides, in particular, an improved process for the preparation of 3-(difluoromethyl)-N-methoxy-1-methyl-N-[(RS)- 1-methyl-2-(2,4,6-trichlorophenyl)ethyl]-1H-pyrazole-4-carboxamide.

The invention relates to the technical field of cloth preparation, and provides a manufacturing process of antistatic grey cloth. The invention relates to an antistatic gray fabric which is obtained by sequentially carrying out padding treatment on a gray fabric through an antistatic finishing agent and an anti-ultraviolet finishing agent, the anti-ultraviolet finishing agent is prepared from the following components in parts by weight: 20 to 25 parts of 2-hydroxy-4-methoxy-5-benzophenone sulfonate, 5 to 6 parts of 4-methoxy isoamyl cinnamate, 15 to 18 parts of zinc oxide, 2 to 4 parts of a surfactant, 1 to 3 parts of a de-foaming agent, 3 to 6 parts of a methoxy-containing phenolic compound, 15 to 20 parts of ethanol and 80 to 85 parts of water; the phenolic compound containing the methoxy group comprises 2-methoxy-4-methylphenol and 4-ethyl-2-methoxyphenol, and the weight ratio of the 2-methoxy-4-methylphenol to the 4-ethyl-2-methoxyphenol is (1-9): 1. According to the technical scheme, the problem that the anti-ultraviolet performance of the gray fabric is poor in the prior art is solved.

The application belongs to the technical field of fine chemical industry, and particularly relates to a synthesis method of 4-methoxy-2-methylaniline, which comprises the following steps: (1) synthesis: 4-methoxy-2-methylaniline, chlorobenzene, a catalyst, an acid binding agent and an imidazole-based catalyst are sequentially added into a reaction kettle, and after stirring until the system is uniformly dispersed, heat preservation is carried out for reaction, after the reaction is completed, the system is cooled to room temperature, and after post-treatment, an oily substance is obtained; (2) recrystallization: a mixed solvent of ethanol and water is added into the oily substance obtained in step (1), the system is heated to reflux and heat preserved for 0.5 h, then the cooling speed and stirring speed are controlled for crystallization, when the temperature of the system is reduced to 10 DEG C, the system is aged for a period of time, and then filtration and washing are carried out to obtain 4-methoxy-2-methylaniline. The product obtained by the method has a yield of 97.2% and a purity of more than 99%, has the advantages of less waste, high economic benefit, high atomic economy and the like, and is easy to implement in industrialization.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a synthesis method of 4-methoxy-2-methyldiphenylamine, which comprises the following steps: (1) synthesis: sequentially adding 4-methoxy-2-methylaniline, chlorobenzene, a catalyst, an acid-binding agent and an imidazole cocatalyst into a reaction kettle, stirring until the system is uniformly dispersed, keeping the temperature for reaction, and cooling to room temperature to obtain 4-methoxy-2-methyldiphenylamine; after the reaction is finished, cooling to room temperature, and carrying out post-treatment to obtain an oily substance; and (2) recrystallization: adding a mixed solvent of ethanol and water into the oily substance obtained in the step (1), heating to reflux, keeping the temperature for 0.5 h, then controlling the cooling speed and the stirring speed to crystallize, growing the crystal for a period of time when the temperature of the system is reduced to 10 DEG C, and then filtering and washing to obtain the 4-methoxy-2-methyldiphenylamine. The yield of the product obtained by the method can reach 97.2%, and the purity can reach 99% or above; the method has the advantages of few three wastes, high economic benefit, high atom economy and the like, and is easy for industrial implementation.

The invention discloses a synthesis method of an aromatic intermediate, namely 1-bromo-2-methoxy-4-methyl-5-nitrobenzene. The synthesis method comprises the following steps: adding a catalyst into a reaction kettle; the method comprises the following steps: by taking o-toluidine as an initial raw material, acetylating and fluorinating, removing acetyl, reacting with sodium methoxide to obtain 4-methoxy-2-methylaniline, oxidizing amino into nitryl by using 30% hydrogen peroxide, and finally catalyzing by using methanesulfonic acid-thianthrene as a catalyst to obtain the 1-bromo-2-methoxy-4-methyl-5-nitrobenzene. The method for synthesizing the 1-bromo-2-methoxy-4-methyl-5-nitrobenzene, provided by the invention, is novel and has simple steps. The method is simple, mild, low in cost, high in product purity and stable in yield.

This invention discloses a method for synthesizing 3-bromo-6-methoxy-2-methylbenzoic acid, belonging to the field of pesticide intermediate synthesis. The synthesis method involves mixing methanol, acid, 3-nitro-2-methylbenzoate, and a metal catalyst, reacting them in a hydrogen atmosphere, and then post-processing to obtain compound B. Compound B, hydrobromic acid solution, and sodium nitrite solution are mixed and stirred, and a hydrobromic acid solution containing a copper catalyst is added, followed by a first-stage stirring reaction and a second-stage stirring reaction, and then post-processing to obtain compound C. Compound C, methanol, water, and alkali are mixed and hydrolyzed, and then post-processed to obtain 3-bromo-6-methoxy-2-methylbenzoic acid. This invention uses 3-nitro-2-methylbenzoate as a raw material and synthesizes the target product through three steps, which has the advantages of simple steps and ease of industrialization.

The application discloses a nitrogen-doped carbon supported cobalt monatomic / nanocluster dual-size catalyst and a preparation method and application thereof, and belongs to the technical field of biomass catalytic conversion. The preparation method provided by the application comprises the following steps: A) mixing a cobalt salt, a carbon source and a nitrogen source in water, stirring at normal temperature, then high-temperature stirring and evaporating to dryness, and obtaining a mixture one after drying; grinding the mixture one and performing carbonization under an inert atmosphere to obtain a nitrogen-doped carbon supported cobalt monatomic catalyst; B) adding the nitrogen-doped carbon supported cobalt monatomic catalyst into a cobalt salt aqueous solution, stirring at normal temperature, then high-temperature stirring and evaporating to dryness, and obtaining a mixture two after drying; grinding the mixture two and performing high-temperature reduction under a reducing atmosphere, and the catalyst is obtained. The catalyst has the advantages of simple preparation process, easily available raw materials and low preparation cost. When the catalyst is applied to the preparation of 2-methoxy-4-methylphenol by vanillin hydrogenation and deoxidization, the catalyst has high catalytic activity and good cycle stability.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of a fenerenone intermediate 4-cyano-2-methoxybenzaldehyde. The method comprises the following steps: adding 3-methoxy-4-methylbenzonitrile into chlorobenzene, adding N, N-dimethylformamide dimethyl acetal while stirring, carrying out a heating reaction, after the reaction is finished, carrying out vacuum concentration to remove the chlorobenzene, adding an organic solvent and water, adding sodium periodate at a controlled temperature, after the heat preservation reaction is finished, carrying out centrifugal filtration to remove sodium iodate, and separating the filtrate to obtain the 3-methoxy-4-methylbenzonitrile. And concentrating and drying an organic phase, adding a saturated alkane solvent, and crystallizing to obtain the 4-cyano-2-methoxybenzaldehyde. The method has the advantages of simple synthetic route, convenience in operation, low cost, small amount of three wastes, environment friendliness, recyclable solvent and high product purity, and is more suitable for industrial mass production.

The invention discloses a preparation method of 3-bromine-2-methoxyl-6-methyl benzoic acid. The 3-bromine-2-methoxyl-6-methyl benzoic acid is an important intermediate for medicine synthesis. A route is shown as follows: m-methylphenol is taken as a raw material, tert-butyl occupation is introduced to positions 2 and 4 through Fokker alkylation, then etherification reaction is performed, 2-methoxy-6-methyl-4, 6-di-tert-butyl benzoic acid is generated under the condition of carbon dioxide by preparing a Grignard reagent, and the 2-methoxy-6-methyl-4, 6-di-tert-butyl benzoic acid is prepared. Finally, the final product 3-bromine-2-methoxy-6-methyl benzoic acid is obtained through a Focker alkylation reverse reaction and bromination. The synthesis method provided by the invention overcomes the defects of the prior art, improves the production safety and shortens the reaction time. And by introducing tert-butyl, the generation of byproducts in the subsequent bromination reaction process is effectively avoided, and the reaction yield is remarkably improved.

The present invention relates to formulations of farnesol X receptor agonists. Specifically, described herein are pharmaceutical formulations of the farnesoid X receptor agonist 3-hydroxyazetidine-trans-1-carboxylic acid 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl) pyridin-2-yl) ((4-(4-methoxy-3-methylphenyl) bicyclo [2.2. 2] octane-1-yl) methyl) carbamoyl) cyclohexyl, and methods for preparing the pharmaceutical formulations of the farnesoid X receptor agonist 3-hydroxyazetidine-trans-1-carboxylic acid. And methods of treating conditions, diseases, or conditions associated with farnesoid X receptor activity using such pharmaceutical formulations.

Novel compounds, such as phenethylamines having a 5-methoxymethyl or 5-hydroxymethyl substituent, are provided. In some aspects, pharmaceutical compositions comprising the compounds, methods of synthesizing the compounds, and methods of using such compounds, including their administration to subjects, are also provided. In some aspects, useful features of the compounds include neuromodulatory and / or anti-inflammatory activity, for example via activation of serotonin receptors. In some further aspects, the compounds are useful as therapeutic agents for treating medical conditions, such as psychiatric disorders and inflammatory conditions, including inflammation and inflammatory diseases and disorders.

The invention relates to the field of composite materials, in particular to an epoxy carbon fiber sheet, E51 type epoxy resin is subjected to methoxy-terminated methyl phenyl organic silicon graft modification to optimize the toughness and heat resistance of a matrix, carbon fibers are subjected to concentrated nitric acid ultrasonic treatment and then modified with a silane coupling agent KH-560 to enhance the interface bonding force between the carbon fibers and the matrix, and the epoxy carbon fiber sheet is prepared. The preparation method comprises the following steps: performing maleic anhydride grafting modification on ethylene propylene diene monomer to improve the overall impact resistance of the sheet, matching the three modified raw materials with a curing agent, a compatilizer, a dispersing agent and the like according to a reasonable ratio, preparing a resin premixing system, preparing a carbon fiber prepreg, and performing segmented hot-pressing curing to obtain the product. The problems that an epoxy resin matrix and a carbon fiber product are too long in forming time and too many people are used are effectively solved, the product efficiency is remarkably improved, the cost is reduced, the mechanical strength, heat resistance and aging-resistant stability of the sheet are improved, and the sheet can be widely applied to the fields of industrial structure reinforcement, traffic equipment manufacturing and the like and has wide application prospects.

The invention relates to a preparation method of (S)-3-hydroxy-4-methoxy-5-methyl phenylalaninol and a preparation method of the (S)-3-hydroxy-4-methoxy-5-methyl phenylalaninol. Specifically, 5-bromo-2-methoxy-3-methylphenol is taken as a starting raw material, (S)-3-hydroxy-4-methoxy-5-methyl phenylalaninol is prepared through a five-step reaction, a chiral center is introduced through a key step a1, a chiral product is high in yield and good in purity, reaction conditions are mild, a route is short, and industrial production is easy.