11 results about "Methoxymethylbenzene" patented technology

Described herein is the farnesoid X receptor agonist, 4-((4-(1-(tert-butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts, solvates, and formulations thereof.

The invention is applicable to the technical field of biomass energy catalysis and conversion, and provides a high-activity and high-stability nickel-cobalt alloy catalyst and a synthesis method and application thereof, and the synthesis method comprises the following steps: preparing S-1 zeolite; the preparation method comprises the following steps: mixing S-1 zeolite with an aqueous solution of Ni (NO3) 2.6 H2O and an aqueous solution of Co (NO3) 2.6 H2O for dipping, placing the mixture in a tetrapropylammonium hydroxide solution for hydro-thermal treatment, and performing static calcination to obtain a NixCoyO at S-1 nanocrystal; mixing the NixCoyO (at) S-1 nanocrystal with polymers P123, F127, dopamine hydrochloride and 1, 3, 5-trimethylbenzene, performing ultrasonic dispersion in a mixed solvent of water and ethanol, adding ammonia water for reaction, and collecting NixCoyO (at) S-1 (at) mPDA; and carrying out carbonization and reduction on the NixCoyO (at) S-1 (at) mPDA to obtain the NixCoy (at) S-1 (at) mC catalyst. The prepared catalyst has excellent hydrodeoxygenation performance, vanillin can be efficiently converted into 2-methoxy-4-methylphenol (MMP) under mild conditions, and the yield exceeds 94%.

The invention discloses a synthesis method of a diene liquid crystal monomer, which comprises the following steps: S1, Grignard addition reaction: carrying out Grignard addition reaction on substituted cyclohexyl N-methoxy-N-methyl benzamide and a substituted cyclohexyl methyl chloride Grignard reagent to obtain a ketone intermediate; s2, the ketone intermediate sequentially reacts with 5, 5-dibromobarbituric acid for a bromination reaction, then sodium formate is added into an alcohol solvent for a hydroxylation reaction, then sodium borohydride is added for a reduction reaction, and a vicinal diol intermediate is obtained; and S3, carrying out an orthoformate reaction on the vicinal diol intermediate obtained in the step S2 and triethyl orthoformate in a fluorine-containing alcohol solvent, then heating to reflux, and carrying out an elimination reaction to obtain the target diene liquid crystal monomer. According to the invention, a traditional double bond construction strategy of multiple Wittig reactions is abandoned, a new synthesis route which takes the Grignard reaction as a starting point and finally constructs a diene structure by a one-pot method through a low-temperature orthoformate / elimination reaction carried out in a specific fluorine-containing solvent is designed, the route is simple, the total yield is high, and the overall cost is lower.

The present invention relates to an improved process for the preparation of phenyl-substituted 3- difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid methoxy-[1-methyl-2-phenyl-ethyl]-amides, in particular, an improved process for the preparation of 3-(difluoromethyl)-N-methoxy-1-methyl-N-[(RS)- 1-methyl-2-(2,4,6-trichlorophenyl)ethyl]-1H-pyrazole-4-carboxamide.

The invention relates to the technical field of cloth preparation, and provides a manufacturing process of antistatic grey cloth. The invention relates to an antistatic gray fabric which is obtained by sequentially carrying out padding treatment on a gray fabric through an antistatic finishing agent and an anti-ultraviolet finishing agent, the anti-ultraviolet finishing agent is prepared from the following components in parts by weight: 20 to 25 parts of 2-hydroxy-4-methoxy-5-benzophenone sulfonate, 5 to 6 parts of 4-methoxy isoamyl cinnamate, 15 to 18 parts of zinc oxide, 2 to 4 parts of a surfactant, 1 to 3 parts of a de-foaming agent, 3 to 6 parts of a methoxy-containing phenolic compound, 15 to 20 parts of ethanol and 80 to 85 parts of water; the phenolic compound containing the methoxy group comprises 2-methoxy-4-methylphenol and 4-ethyl-2-methoxyphenol, and the weight ratio of the 2-methoxy-4-methylphenol to the 4-ethyl-2-methoxyphenol is (1-9): 1. According to the technical scheme, the problem that the anti-ultraviolet performance of the gray fabric is poor in the prior art is solved.

The application belongs to the technical field of fine chemical industry, and particularly relates to a synthesis method of 4-methoxy-2-methylaniline, which comprises the following steps: (1) synthesis: 4-methoxy-2-methylaniline, chlorobenzene, a catalyst, an acid binding agent and an imidazole-based catalyst are sequentially added into a reaction kettle, and after stirring until the system is uniformly dispersed, heat preservation is carried out for reaction, after the reaction is completed, the system is cooled to room temperature, and after post-treatment, an oily substance is obtained; (2) recrystallization: a mixed solvent of ethanol and water is added into the oily substance obtained in step (1), the system is heated to reflux and heat preserved for 0.5 h, then the cooling speed and stirring speed are controlled for crystallization, when the temperature of the system is reduced to 10 DEG C, the system is aged for a period of time, and then filtration and washing are carried out to obtain 4-methoxy-2-methylaniline. The product obtained by the method has a yield of 97.2% and a purity of more than 99%, has the advantages of less waste, high economic benefit, high atomic economy and the like, and is easy to implement in industrialization.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a synthesis method of 4-methoxy-2-methyldiphenylamine, which comprises the following steps: (1) synthesis: sequentially adding 4-methoxy-2-methylaniline, chlorobenzene, a catalyst, an acid-binding agent and an imidazole cocatalyst into a reaction kettle, stirring until the system is uniformly dispersed, keeping the temperature for reaction, and cooling to room temperature to obtain 4-methoxy-2-methyldiphenylamine; after the reaction is finished, cooling to room temperature, and carrying out post-treatment to obtain an oily substance; and (2) recrystallization: adding a mixed solvent of ethanol and water into the oily substance obtained in the step (1), heating to reflux, keeping the temperature for 0.5 h, then controlling the cooling speed and the stirring speed to crystallize, growing the crystal for a period of time when the temperature of the system is reduced to 10 DEG C, and then filtering and washing to obtain the 4-methoxy-2-methyldiphenylamine. The yield of the product obtained by the method can reach 97.2%, and the purity can reach 99% or above; the method has the advantages of few three wastes, high economic benefit, high atom economy and the like, and is easy for industrial implementation.

This invention discloses a method for synthesizing 3-bromo-6-methoxy-2-methylbenzoic acid, belonging to the field of pesticide intermediate synthesis. The synthesis method involves mixing methanol, acid, 3-nitro-2-methylbenzoate, and a metal catalyst, reacting them in a hydrogen atmosphere, and then post-processing to obtain compound B. Compound B, hydrobromic acid solution, and sodium nitrite solution are mixed and stirred, and a hydrobromic acid solution containing a copper catalyst is added, followed by a first-stage stirring reaction and a second-stage stirring reaction, and then post-processing to obtain compound C. Compound C, methanol, water, and alkali are mixed and hydrolyzed, and then post-processed to obtain 3-bromo-6-methoxy-2-methylbenzoic acid. This invention uses 3-nitro-2-methylbenzoate as a raw material and synthesizes the target product through three steps, which has the advantages of simple steps and ease of industrialization.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of a fenerenone intermediate 4-cyano-2-methoxybenzaldehyde. The method comprises the following steps: adding 3-methoxy-4-methylbenzonitrile into chlorobenzene, adding N, N-dimethylformamide dimethyl acetal while stirring, carrying out a heating reaction, after the reaction is finished, carrying out vacuum concentration to remove the chlorobenzene, adding an organic solvent and water, adding sodium periodate at a controlled temperature, after the heat preservation reaction is finished, carrying out centrifugal filtration to remove sodium iodate, and separating the filtrate to obtain the 3-methoxy-4-methylbenzonitrile. And concentrating and drying an organic phase, adding a saturated alkane solvent, and crystallizing to obtain the 4-cyano-2-methoxybenzaldehyde. The method has the advantages of simple synthetic route, convenience in operation, low cost, small amount of three wastes, environment friendliness, recyclable solvent and high product purity, and is more suitable for industrial mass production.

Novel compounds, such as phenethylamines having a 5-methoxymethyl or 5-hydroxymethyl substituent, are provided. In some aspects, pharmaceutical compositions comprising the compounds, methods of synthesizing the compounds, and methods of using such compounds, including their administration to subjects, are also provided. In some aspects, useful features of the compounds include neuromodulatory and / or anti-inflammatory activity, for example via activation of serotonin receptors. In some further aspects, the compounds are useful as therapeutic agents for treating medical conditions, such as psychiatric disorders and inflammatory conditions, including inflammation and inflammatory diseases and disorders.

The invention relates to the field of composite materials, in particular to an epoxy carbon fiber sheet, E51 type epoxy resin is subjected to methoxy-terminated methyl phenyl organic silicon graft modification to optimize the toughness and heat resistance of a matrix, carbon fibers are subjected to concentrated nitric acid ultrasonic treatment and then modified with a silane coupling agent KH-560 to enhance the interface bonding force between the carbon fibers and the matrix, and the epoxy carbon fiber sheet is prepared. The preparation method comprises the following steps: performing maleic anhydride grafting modification on ethylene propylene diene monomer to improve the overall impact resistance of the sheet, matching the three modified raw materials with a curing agent, a compatilizer, a dispersing agent and the like according to a reasonable ratio, preparing a resin premixing system, preparing a carbon fiber prepreg, and performing segmented hot-pressing curing to obtain the product. The problems that an epoxy resin matrix and a carbon fiber product are too long in forming time and too many people are used are effectively solved, the product efficiency is remarkably improved, the cost is reduced, the mechanical strength, heat resistance and aging-resistant stability of the sheet are improved, and the sheet can be widely applied to the fields of industrial structure reinforcement, traffic equipment manufacturing and the like and has wide application prospects.