107results about How to "Three wastes are produced less" patented technology

The invention discloses a method and a device for continuously producing dyes. The method comprises the following steps: adding diazotization reaction raw materials into an ingredient kettle, controlling temperature in the kettle, allowing the materials to flow in a tubular reactor through an overflow orifice, detecting the reaction state through an online detection device, continuously discharging the diazotization compound solution obtained through the reaction, continuously feeding the diazotization compound solution and a coupling component solution according to a specified ratio, allowing the materials to flow into the tubular reactor through the overflow orifice, detecting the reaction state through the online detection device, transferring the coupling reaction materials into a crystal transformation kettle, performing crystal transformation, and performing filter pressing to obtain a dye filter cake, wherein the filter cake mother solution and the wash water are circulated for preparing the coupling component solution. The reaction temperature, material flow and reaction state detection device are automatically subjected to interconnected control. According to the method, automatic and continuous dye production is realized, the production capacity, the product quality and yield are improved, the labor intensity and working conditions of workers are improved, the waste water, water gas and waste residue amounts in the dye production process are greatly reduced, and circular economy and cleaner production process are realized.

The invention provides a preparation method of high purity trifluridine. The method is as below: reacting a raw material of a compound 2 with HMDS under the action of trimethylchlorosilane to obtain a compound 3; subjecting the compound 3 and a compound 4 to condensation in the presence of a catalyst copper difluoride; conducting ethanol recrystallization to obtain a compound 5; and finally conducting deprotection on the compound 5 under the effect of sodium methylate; and recrystallizing by a mixed solvent of ethanol and acetone (1:1) to obtain the high purity object compound 1. The method has the advantages of high purity of the product, simpleness, easy purification and less industrial pollution.

The invention relates to a synthetic method of 2-cyanogroup-4-nitro-6-bromaniline diazosalt, solving the technical problems of simple technique and operation, low requirement for production field andequipment, and low energy consumption and low 'three wastes'. The invention comprises the following steps: using o-cyanogroup paranitroaniline as a raw material, pulping in the sulphuric acid at the mass percent of 10% to 98%, adding brominated compound and oxidant for bromination, and directly diazotizing the mixture with the diazotized agent after bromination to obtain the product, wherein the molar ratio of o-cyano paranitroaniline sulphuric acid, brominated compound, oxidant and diazotized agent is 1:3.0 to 20.0:0.5 to 1.5:0.4 to 1.5:1.0 to 2.0.

The invention discloses a method and a device for automatic-control continuous production of dye. The method comprises that raw materials are metered, are continuously fed into a tubular reactor and undergo a reaction and the products are discharged continuously. The device is characterized in that a reactor is provided with multiple reaction state detection devices; through multipoint automatic control, the reaction liquid obtained by the reaction is timely transferred to a next process; and abnormal materials in blending are timely pumped back to a blending kettle and then are re-blended. The method and the device realize accurate and automatic-control continuous production of dye, guarantee stable product quality, shorten production time, improve production efficiency, reduce a production cost, reduce three wastes, realize pollution and energy consumption reduction, and realize recycling economy and clean production.

The invention relates to a method for preparing 4-trifluoromethylphenyl piperazine, which comprises the following steps of: firstly, reacting diethanol amine with thionyl chloride to obtain bis(2-chloroethyl)amine, reacting 4-trifluoromethylaniline with bis(2-chloroethyl)amine in normal butanol or diethylene glycol monomethyl ether under the heating condition to obtain 4-trifluoromethylphenyl piperazine hydrochloride, and neutralizing with an alkaline to obtain the 4-trifluoromethylphenyl piperazine. The method for preparing the 4-trifluoromethylphenyl piperazine has the advantages of high reaction yield, less production of three wastes, easy reaction control, small production danger, simple product purification, high content and the like.

The invention belongs to the technical field of preparation of materials with protection functions, and particularly relates to a preparation method of an attapulgite-based full-wave-band ultravioletshielding material. The preparation method comprises the steps that a cation surfactant solution is added into attapulgite slurry, then a coupling agent solution is added, full mixing and heat-preservation curing are conducted, and organic surface-modified attapulgite is prepared; obtained attapulgite is dispersed in ethyl acetate, MBBT is added, full mixing and heating are conducted to remove ethyl acetate, and the ATPatMBBT composite material, namely the attapulgite-based full-wave-band ultraviolet shielding material, is obtained.

The invention discloses a 3,4-difluorobenzonitrile preparation method. The 3,4-difluorobenzonitrile preparation method comprises the following steps of taking 3,4-difluorobenzonitrile as a raw material, potassium fluoride as a fluorinated reagent and bis-(N,N'-1,3-dimethyl-2-imidazolinyl)-chloride ammonium salt as a phase transfer catalyst, then adding a reducing agent and a dispersant, and performing reaction to prepare the 3,4-difluorobenzonitrile. In the method, the temperature of fluorination reaction is relatively low, the reaction time is short, the total molar yield can reach about 90 percent, and the solvents and the catalyst can be recycled; produced potassium chloride in reaction becomes a pure product with the purity being 99 percent or above after recrystallization, and the pure product can be directly sold, so that the production cost is reduced; in addition, the technology is safe and environmentally friendly, is small in quantities of three wastes (waste water, waste solid and waste gas) and is suitable for industrial production.

The invention belongs to the technical field of aluminum melting insulating furnaces, in particular to an aluminum melting insulating connecting furnace. The aluminum melting insulating connecting furnace comprises a box body which is internally provided with a cuboid aluminum melting insulating pool. A plurality of molten aluminum partition blocks are arranged at the upper end inside the aluminum melting insulating pool at intervals, the upper end of the box body is provided with an integrated upper cover, and a charging port, a gas vent and a liquid taking port are formed in the upper cover. A ceramic filtering plate is arranged on one side inside the aluminum melting insulating pool below the liquid taking port, and a plurality of electric heating devices are arranged on the box body. According to the aluminum melting insulating connecting furnace, thermal loss can be effectively reduced, the insulating effect is improved, energy consumption is reduced, production cost is saved, industrial wastewater, waste gases and residues are reduced, and energy and resource consumption of the society is reduced, the environment is protected, and the atmosphere pollution is reduced.

The invention relates to a synthetic method of piribedil. The synthetic method is a brand new process comprising the steps of synthesizing piperonyl piperazine in one step under the effects of pentamethyleneamine, piperazine pyrimidine and paraformaldehyde, and reacting by virtue of piperonyl piperazine and dichloropyrimidine so as to synthesize piribedil. Piperonyl piperazine has not been synthesized by virtue of the synthetic method before. Compared with a traditional synthetic method of piribedil, the synthetic method has the advantages that synthetic steps are simplified, the three wastes are reduced, the utilization ratio of pentamethyleneamine is remarkably increased, and the after-treatment is relatively environment-friendly.

The invention relates to a method of continuously preparing 3,5,5-trimethyl-3-cyclohexene-1-one (beta-isophorone) by utilization of a heterogeneous catalyst. 3,5,5-trimethyl-2-cyclohexene-1-one is adopted as a raw material, and is subjected to an isomerization reaction by adoption of a reactive distillation column under conditions of a solid alkali catalyst without adding other organic alkalis to obtain the 3,5,5-trimethyl-3-cyclohexene-1-one. The method has advantages of high conversion ratio, good selectivity, less heavy components, easy catalyst recovery, and the like and is a green synthetic process.

The invention relates to the field of organic synthesis, in particular to a preparation method of a trifluoroacetophenone derivative. Substituted aniline is used as a raw material, and preparation of the trifluoroacetophenone derivative is completed through three steps including diazotization reaction, coupling reaction and hydrolysis reaction. The preparation method has the advantages of simple process, high yield and less three wastes generated by the whole reaction, and is suitable for large-scale industrial production.

A method for preparing 5-acetoxyl-3-indole carboxylic acid ethyl ester. The invention relates to a method for preparing the 5-acetoxyl-3-indole carboxylic acid ethyl ester which is a key intermediate of a widely-used antiviral drug Arbidol Hydrochloride. The method successively comprises the following steps that, by using 3-chlorine-4-nitrophenol as raw materials, phenolic hydroxyl groups are reacted with an acetylation reagent, then products obtained are subjected to a substitution reaction with sodium salt of malonate, and at last a hydrogenated cyclization reaction is carried out under pressurized conditions to get the 5-acetoxyl-3-indole carboxylic acid ethyl ester. The method provides a novel synthesizing route, and has advantages of concise steps, simple technology and cheap and easily-available raw materials. Each reaction step is relatively conventional operations and production cost can be effectively reduced.

The invention provides a preparation method of 4-nitro-3-trifluoromethylaniline. The preparation method comprises the following steps: nitrifying m-trifluoromethyl)phenyl]acetamide obtained by reacting m-(trifluoromethyl)aniline with acetylchloride in a non-protic solvent so as to obtain 4-nitro-3-trifluoromethylacetanilide; and removing acetyl protection in ethanol solution by potassium carbonate so as to obtain the 4-nitro-3-trifluoromethylaniline. The preparation method has the advantages that reaction yield is high, generated three wastes are less, reaction is easy to control, impurities in product position positional isomers are less, yield is high, rectification is simple and the like.

The invention relates to a preparation method for N-[2-(2-hydroxyethoxy)-4-nitrophenyl] ethanol amine. The preparation method comprises the following steps: mixing 2-amino-5-nitrophenol used as a raw material with an alkali and a solvent, then adding a hydroxyethylation reagent, and reacting at certain pressure and temperature to generate 2-(3-nitro-6-aminophenoxy) ethanol; and then reacting 2-(3-nitro-6-aminophenoxy) ethanol with chloroethyl chloroformate under the action of a catalyst, and obtaining N-[2-(2-hydroxyethoxy)-4-nitrophenyl] ethanol amine through condensation and hydrolysis. The N-[2-(2-hydroxyethoxy)-4-nitrophenyl] ethanol amine disclosed by the invention has the advantages of being high in yield, high in purity, good in quality, moderate in production process, less in three-waste generation, and the like; the preparation method disclosed by the invention is economical and environmentally friendly, and suitable for industrialized production.

The invention discloses a preparation method of 2-azanoradamantane-N-Oxyl (Nor-AZADO). The method comprises the following steps: placing acetonedicarboxylic acid, glutaraldehyde and benzylamine in an aqueous hydrophosphate solution, and carrying out condensation and decondensation to obtain 9-benzyl-9-azabicyalo-[3,3,1]-nonyl-3-one; carrying out condensation dehydration on 9-benzyl-9-azabicyalo-[3,3,1]-nonyl-3-one and benzene or benzene ring substituted sulfohydrazide, and adding an alkali to obtain 2-(9-benzyl-9-azabicyalo-[3,3,1]-nonane-3-ylidene)-1-benzene or benzene ring substituted sulfohydrazide sodium/potassium salt; carrying out refluxing ring closing on the 2-(9-benzyl-9-azabicyalo-[3,3,1]-nonane-3-ylidene)-1-benzene or benzene ring substituted sulfohydrazide sodium/potassium salt in an organic solvent to obtain N-benzyl-2-azanoradamantane; debenzylating N-benzyl-2-azanoradamantane to obtain 2-azanoradamantane; and oxidizing 2-azanoradamantane by a peroxide oxidant to obtain the Nor-AZADO. The preparation method has the advantages of great increase of the synthesis yield, greenness and environmental protection, high efficiency, low cost, and easiness in industrial large-scale production.

The invention provides a refining method of high-purity propofol, which comprises the following steps of: adding an organic solvent into an industrial propofol crude product, then adding an inducer, freezing and crystallizing, filtering to remove impurities which are still liquid, heating and melting a filter cake, repeating the step until the requirements of related substances are met, carrying out reduced pressure distillation, and collecting stable fractions to obtain the high-purity propofol. The method is ingenious in conception, simple in process and suitable for industrial production, the single impurity of the prepared propofol is smaller than 0.05%, and the liquid phase purity can reach 99.9% or above.