35results about How to "Has potential application value" patented technology

The invention relates to a 4-phenyl-6H-1,3-oxazine-6-one derivative, a preparation method and application thereof, and provides a class of 4-phenyl-6H-1,3-oxazine-6-one derivatives represented by a formula (III). According to the invention, the preparation method is mild in condition, simple and safe to operate and relatively high in yield, and the 4-phenyl-6H-1,3-oxazine-6-one derivative obtainedby the invention has aggregation-induced emission (AIE) characteristics and can be applied to the photoelectric field.

The invention provides a method for classifying and extracting xylogen and xylo-oligosaccharide in papermaking black liquid. The method mainly comprises the following steps: diluting papermaking blackliquid, regulating the pH value, ageing, standing, and performing centrifugal separation to obtain centrifugate and a solid precipitate; performing rotary evaporation concentration on the centrifugate, dripping ethanol to precipitate, and performing centrifugal separation to obtain solid xylo-oligosaccharide; purifying and dissolving the solid precipitate with a methanol / acetone mixed solution; dripping an ethyl acetate solvent to precipitate, and performing centrifugal separation to obtain xylogen F1 and centrifugate; performing rotary evaporation concentration on the centrifugate, drippingan ethyl acetate / petroleum ether mixed solution to precipitate, and performing centrifugal separation to obtain xylogen F2 and centrifugate; and performing rotary evaporation concentration on the centrifugate, dripping petroleum ether to precipitate, and performing centrifugal separation, thereby obtaining xylogen F3 and xylogen F4 in the centrifugate. The method disclosed by the invention is capable of realizing classification and separation of xylogen and recycling of the xylo-oligosaccharide in bagasse papermaking black liquid, is wide in application range, simple in process and reliable intechnology and has actual application and popularization value.

The invention discloses a preparation method of [1,2,4]oxadiazinoindoline-3-one derivatives, comprising the following steps: (1) preparing an o-nitrophenylacetylene compound, a catalyst and a first organic After the solvents are mixed, react at room temperature for 3-6h; (2) add α-halogenated hydroxamate compound, sodium carbonate and hexafluoroisopropanol to the material obtained in step (1), and react for 10 h at room temperature ‑12h; or mix o-nitrophenylacetylene compound, catalyst, α‑halogenated hydroxamate compound, sodium carbonate and hexafluoroisopropanol and react at 55‑65°C for 10‑12h. The invention can synthesize [1,2,4]oxadiazinoindoline-3-one derivatives with various substituents which are difficult to synthesize by other methods, and has far-reaching significance from the perspective of organic chemistry.

The invention discloses an antibody type molecular chaperone capable of inhibiting Tau protein from being aggregated. The antibody type molecular chaperone scFv T1 can effectively inhibit Tau aggregation, is strong in specificity, high in efficiency and low in toxicity and easy to eliminate in the body, and has the advantages of being humanized, convenient for antibody screening, easy to prepare and the like compared with monoclonal or polyclonal antibody prepared by using the traditional method; compared with common immune globulin, the single-stranded antibody has smaller molecules, is easier to express in animal cells in-vitro or in-vivo cultured in model organism, can break through blood brain barrier, has low toxic and side effects, cannot cause immunoreactions easily, can facilitate the research on cell and animal levels and the clinical treatment and applications of Alzheimer disease, thus providing a new direction for treatment of Alzheimer disease, and having potential application values for treating AD, and good medical application prospects.