The invention discloses a maifanite-containing double-effect multi-component organic / inorganic compound mixed fertilizer and a manufacturing method thereof. The maifanite-containing double-effect multi-component organic / inorganic compound mixed fertilizer is low-carbon and environment-friendly and produced by organic combination of natural components including humic acid, maifanite, bentonite, potassium oxide, ammonium phosphate, ammonium chloride, borax, zinc sulfate, aluminum potassium sulfate, and traditional Chinese medicines for agricultural use (including aloe, Tripterygium wilfordii, onion juice, tobacco stem, Radix Glycyrrhizae, Aconitum kusnezoffii and Pyreyhrum), biological enzyme activators and a PASP plant growth promoter at normal temperature and pressure. The manufacturing method comprises the following steps: grinding multiple raw materials in the formula to powder of about 120 to 200 meshes, thoroughly mixing according to the given ratio in a stirring machine, conveying to a granulating machine through a conveyor, chelating by spraying a PASP aqueous solution and curing and drying at a high temperature by use of a drying machine, sieving to obtain the fertilizer product which has a diameter of 2.5 to 4.5 mm, a strength of 5 to 6 n and a free moisture of less than 10%, and quantitatively bagging after the product passes the quality test. The fertilizer product has complete nutrients and balanced nutrition, is rich in organic matters and amino acids, can activate and utilize residual fertilizers in the soil, improves yield and quality of crops, produces green and organic agricultural products, helps increase farmer's incomes, well solves the problems and difficulties caused by long-term use of chemical fertilizers in agricultural production and farming, overcomes the defects of chemical fertilizers, and truly meets the national industrial policy requirements for economic and social benefits of green, organic and environment-friendly sustained- / controlled-release fertilizers.