The invention relates to the field of disease and pest control, and provides a green and safe disease and pest control method. Staging control is carried out according to different growth periods of plants. The specific control sequences and steps are as follows: (1), disease and pest control in the early stage comprises: control on damping-off, sheath blight and stubby root nematode before soil is not cultivated, and control on pests having relatively high mobility or needing adults to lay eggs and hatch, such as locusts, armyworms and moths, before plants are planted; (2), disease and pest control in seedling raising and seedling stages comprises: selection and use of disease-resistant varieties and health seedlings, disinfection of seeds and substrates, and control on whiteflies, flea beetles and cutworms in the seedling stage; and (3), disease and pest control in field planting and after field planting comprises: environmental management, water and fertilizer management, and adoption of different botanical fungicides and methods for different diseases and pests. Besides, the invention specifically discloses specific disease and pest control methods of Chinese cabbages, tomatoes, strawberries and hami melons. The green and safe disease and pest control method in the invention has the benefits that: a disease and pest control system is formed; and the method is wide in application range, good in effect and free from pesticide residue.