37 results about "Sugar absorption" patented technology

The invention provides a preparation method and application of fructus cannabis protein peptide with a sugar absorption blocking effect, and belongs to the technical field of functional active peptides, and the preparation method comprises the following steps: crushing fructus cannabis, and degreasing through low-temperature continuous phase change to obtain degreased fructus cannabis meal after degreasing; the degreased hemp seed meal is hydrolyzed through polysaccharase and protease in sequence, low-temperature salting-out is carried out after hydrolysis is finished, drying and sterilization are carried out, and the hemp seed protein peptide is obtained. The fructus cannabis protein peptide obtained by the technical scheme and the preparation method disclosed by the invention has the following effects: 1, the fructus cannabis protein peptide prepared by the preparation method disclosed by the invention can be used for remarkably inhibiting the activity of alpha-amylase and alpha-glycosidase (the maximum inhibition rates can respectively reach 84.2% and 75.1%), so that digestion and absorption of a human body on carbohydrates such as starch, dextrin and disaccharide are blocked; and 2, double-blind clinical test results show that the fructus cannabis protein peptide prepared by the invention can effectively reduce the postprandial blood sugar peak value and peak area, and the effective sugar breaking rate can reach 30-60%.

The present invention provides an oral composition that can be used for anti-obesity, suppressing fat absorption, suppressing an increase in neutral fat, suppressing sugar absorption, suppressing an increase in blood sugar level, reducing body fat, or reducing BMI. An oral composition containing gallic acid and catechins, The oral composition has a mass ratio of gallic acid:catechins=1:0.1 to 5. The oral composition preferably further contains ellagic acid. It is also preferably used for anti-obesity, suppression of fat absorption, suppression of increase in neutral fat, suppression of sugar absorption, suppression of increase in blood glucose level, reduction of body fat, or reduction of BMI.

The invention relates to the technical field of sugar control and sugar reduction, and discloses a compound sugar control and sugar reduction mixture which is prepared from the following raw materials in parts by mass: shiny-leaved yellowhorn, Chinese yam, rhizoma polygonati, radix puerariae, fructus lycii, folium mori, poria cocos and pericarpium citri reticulatae. The dosage of the shiny-leaved yellowhorn is 2.0-3.5 times that of the Chinese yam, and the dosage of the rhizoma polygonati is 0.8-1.2 times that of the radix puerariae; the dosage of the mulberry leaves is 0.5-0.8 time that of the poria cocos, and the dosage of the dried orange peel is 0.3-0.6 time that of the Chinese wolfberry fruits; the dosage range of the raw materials is as follows: 250 to 550 parts of the shiny-leaved yellowhorn, 80 to 250 parts of the Chinese yam, 80 to 250 parts of the rhizoma polygonati, 120 to 350 parts of the radix puerariae, 120 to 350 parts of the fructus lycii, 80 to 180 parts of the folium mori, 120 to 350 parts of the poria cocos and 30 to 120 parts of the pericarpium citri reticulatae. The active ingredients generate a synergistic effect on the molecular level, the xanthoceras sorbifolia bunge saponin activates an energy metabolism pathway, the Chinese yam polysaccharide delays intestinal sugar absorption, and the polygonatum sibiricum polysaccharide repairs the islet cell function, so that three-dimensional intervention on the pathological link of diabetes is realized, and the limitation of a single ingredient or a single action mechanism is broken through.

The invention relates to the technical field of sugar permeation control, in particular to a sugar permeation processing control method and system for low-sugar preserved fruits, and the method comprises the following steps: S1, pretreating raw materials, and conveying the pretreated raw materials to a sugar permeation unit; s2, obtaining a weight parameter P of the raw materials entering the sugar permeation unit; s3, according to the raw material weight parameter P, calculating a target value C1 of the concentration of the sugar liquid in the sugar supply unit; s4, adjusting the concentration of the sugar solution in the sugar supply unit according to the target value C1 of the concentration of the sugar solution; and S5, monitoring the sugar content of the preserved fruits in the sugar permeation unit, stopping the sugar permeation process when the sugar content of the preserved fruits in the sugar permeation unit is monitored to reach the standard, completing discharging, and quantifying the state of the raw materials into computable parameters by capturing the initial weight and dynamic weight change of the preserved fruits. And accurate adjustment of the concentration is realized through calculation of a sugar solution concentration target value, so that the sugar solution concentration can be adapted in real time along with the sugar absorption or dehydration state of the preserved fruits, and the final sugar degree of the preserved fruits is stabilized in a low-sugar range.

The application belongs to the technical field of biological medicine, and particularly relates to a micro binding protein targeting sodium-glucose cotransporter 2 and a construction method and application thereof. The amino acid sequence of the micro binding protein is shown in SEQ ID NO. 5, and the micro binding protein is a triple helix structure. The micro binding protein targeting sodium-glucose cotransporter 2 (sglt2) provided in the application can be combined with the sglt2 protein as a tool protein, is used for regulating cell glucose absorption, and can be used for fluorescence detection of the sglt2 protein through the micro binding protein marked with a specific label. The micro binding protein in the application can be applied to sglt2 function regulation and fluorescence label detection as a novel sglt2 tool.

The present invention provides an oral composition that can be used for anti-obesity, suppressing fat absorption, suppressing an increase in neutral fat, suppressing sugar absorption, suppressing an increase in blood sugar level, reducing body fat, or reducing BMI. [Solution] An oral composition containing gallic acid and ellagic acid, wherein the mass ratio of gallic acid to ellagic acid in the composition is gallic acid:ellagic acid = 1:0.01 to 0.7. The oral composition is preferably used for one or more purposes selected from anti-obesity, suppression of fat absorption, suppression of increase in triglyceride levels, suppression of sugar absorption, suppression of increase in blood glucose levels, reduction of body fat, and reduction of BMI. The oral composition preferably further contains chebulic acid.

The invention belongs to the field of molecular biology, and particularly relates to application of an MdHT13.2 gene in regulation and control of plant growth. According to RNA-seq (Ribonucleic Acid-Seq) data analysis, MdHT13.2 with high expression quantity in apple leaves is screened out. Mutant yeast sugar absorption complementation experiments show that MdHT13.2 not only has transport activity on hexose such as glucose, fructose and the like, but also has stronger transport capacity on cane sugar. The results of in-situ hybridization of apple leaves and GUS staining experiments of arabidopsis show that MdHT13.2 has a high expression level in the phloem of the vein. The MdHT13.2 as a member in a hexose transporter gene family can regulate and control sugar accumulation in plants and promote growth of the plants.

The invention discloses vegetable paste and a preparation method thereof, and relates to the technical field of food processing, and the vegetable paste comprises the following raw materials in parts by weight: 20-40 parts of spinach, 15-30 parts of pumpkin, 15-25 parts of mushroom, 8-15 parts of lotus root starch, 3-8 parts of olive oil, 10-25 parts of apple, and 55-120 parts of drinking water. The preparation method comprises the following steps: preparing the food materials, cooking the food materials, stirring the food materials, and performing cryopreservation. The vegetable and fruit raw materials are scientifically compounded, so that the balanced combination of rapid and slow carbohydrates is realized, the sugar absorption is delayed, and the relative stability of the blood sugar level is maintained. The prepared vegetable paste is rich in dietary fibers, pectin and various vitamins and minerals, can enhance satiety and improve intestinal health, and has the characteristic of relatively low blood glucose response on the whole. The product can provide healthy, delicious and nutrient-balanced dietary choices for people who control sugar, people who have difficulty in eating after operation, and old people and children who need energy balance.

The invention provides a pharmaceutical composition helpful for reducing blood glucose as well as a preparation and application thereof, and relates to the field of medicines. The pharmaceutical composition helpful for reducing blood glucose comprises the following raw materials in parts by weight: 15-20 parts of pomegranate, 8-13 parts of turmeric, 1-2 parts of bear gall, 1-2 parts of schisandra chinensis, 10-15 parts of dendrobe, 5-10 parts of folium eriobotryae, 8-12 parts of radix puerariae, 5-10 parts of dandelion, 8-15 parts of herba epimedii, 8-12 parts of polygonum cuspidatum, 5-8 parts of gynostemma pentaphyllum, 4-8 parts of inula flower and 3-5 parts of cortex lycii radicis. The pharmaceutical composition disclosed by the invention effectively inhibits sugar absorption of intestinal tracts, enhances insulin sensitivity, improves insulin resistance, promotes activity of glucose transporter protein, regulates glycolipid metabolism balance, inhibits liver glycogen decomposition to reduce liver glucose output and reduces interference of inflammatory factors on insulin signal channels through a multi-channel synergistic effect; therefore, the whole metabolic regulation is optimized, the blood sugar level is remarkably reduced, the number of pancreatic beta cells is increased, and the compound can be applied to preparation of drugs for treating diabetes.

The invention discloses a mulberry leaf fermentation composition helpful for reversing insulin resistance and a preparation method thereof, relates to the technical field of mulberry leaf fermentation treatment, and solves the problem that in the prior art, a technology for preparing auxiliary materials for assisting diabetes treatment from mulberry leaves and related products do not exist. The mulberry leaf fermentation composition is prepared from a mulberry leaf extract, a highland barley extract, a bitter gourd extract, hawthorn powder, yam flour, lemon powder, fructo-oligosaccharide, water-soluble dietary fibers, resistant dextrin and a fermentation microbial preparation, wherein the highland barley extract is prepared by mixing a highland barley flavone extract and a highland barley polysaccharide extract according to a mass ratio of (4-6): 1. Through multi-channel combination of'inhibiting sugar absorption, enhancing insulin signals, protecting islet cells and improving metabolism ', insulin signal channels can be effectively improved, inflammatory oxidative stress can be relieved, glucose and lipid metabolism disorder can be regulated, and insulin resistance can be reversed.

The present invention relates to a rice cake composition having low sugar and low glycemic index characteristics and a method for manufacturing the same. It controls the rate of sugar absorption using substitute sugars and indigestible components, reduces the rate of digestion and absorption in the body through a resistant starch induction process that rearranges the structure of starch, and simultaneously suppresses the hardening phenomenon caused by low-temperature aging, thereby enabling the suppression of glucose spikes that occur when consuming carbohydrates without relying on chemical additives to prevent diabetes and obesity, which are chronic diseases of modern people.

The invention discloses a blood sugar reducing composition containing rumex hanus as well as a preparation method and application thereof, and the blood sugar reducing composition containing rumex hanus is prepared from the following raw materials in parts by weight: 19 to 21 parts of rumex hanus extract, 29 to 31 parts of white kidney bean extract, 8 to 10 parts of arabinose and 30.4 to 49.6 parts of auxiliary components. The invention relates to a preparation method and application of a hypoglycemic composition containing rumex hanus. According to the hypoglycemic composition based on the theory of homology of medicine and food provided by the invention, various plant extracts are scientifically proportioned to play a synergistic effect, so that a multi-way hypoglycemic effect of inhibiting exogenous sugar absorption, regulating endogenous sugar metabolism, improving pancreas islet function and resisting oxidative damage is realized; the composition has the advantages of high safety, small side effect, lasting effect and the like.

The invention relates to the field of functional foods, and discloses a preparation method of a composition for assisting in reducing blood sugar of diabetes based on shiny-leaved yellowhorn leaves. The composition comprises the following components in percentage by mass: 2.00% of rutin, 1.00% of ursolic acid, 3.00% of charantin, 0.05% of chromium picolinate, 2.00% of a mulberry leaf extract, 2.00% of puerarin, 8.00% of an astragalus membranaceus extract, 10.00% of Chinese yam powder, 2.00% of a ginseng extract, 20.00% of oligosaccharide, 48.45% of soluble dietary fibers, 1.00% of erythritol and 0.50% of microcrystalline cellulose. The Xanthoceras sorbifolia leaf double-component extraction is adopted, multiple natural functional factors and a low-GI matrix are matched, and the effect of assisting in reducing blood sugar is achieved through multi-channel synergy of regulating intestinal flora, delaying sugar absorption, enhancing insulin sensitivity and the like. The composition has the advantages of high safety and natural components, can be industrially granulated and produced, and is suitable for auxiliary conditioning of prediabetic people and patients with type 2 diabetes mellitus. The invention also discloses a preparation method and action verification data of the composition.

The invention provides China-hemp peptide nutritional fat-reducing coffee and a preparation method thereof. According to the China-hemp peptide nutritional fat-reducing coffee disclosed by the invention, an efficient and safe fat-reducing effect is realized through a synergistic effect of multiple components. The China-hemp peptide inhibits adipocyte differentiation and promotes fatty acid beta-oxidation, the China-hemp peptide and chlorogenic acid in coffee form a complementary mechanism, the former regulates adipogenesis gene expression, and the latter accelerates existing lipolysis. Body fat accumulation can be reduced through the energy supply characteristic of the hemp seed oil microcapsule powder, and the bioavailability is remarkably improved through emulsification combination of the hemp seed oil microcapsule powder and the hemp peptide. The hemp seed protein powder indirectly reduces fat synthesis by blocking sugar absorption, and the resistant dextrin prolongs satiety and controls heat from an intake end. And the vitamin B group is used as a metabolic coenzyme, so that the energy conversion efficiency is maximized. In the preparation process, directional enzymolysis and gradient mixing technologies solve the industrial problems of bitter taste and instability of the China-hemp peptide.

The invention relates to the technical field of special diet food and diabetes nutrition support, and discloses low-GI diabetes special nutrition formula powder which is prepared from the following components in parts by weight: 22-36 parts of buckwheat, 3-18 parts of yellow millet, 1-5 parts of quinoa flour, 1-6 parts of konjak, 1-6 parts of resistant starch, 1-6 parts of soybean protein isolate, 6-10 parts of wheat germ and 3-8 parts of phaseolus calcaratus. The special nutritional formula powder for the low-GI diabetes mellitus is prepared by compounding low-GI whole grains and medicinal and edible raw materials, so that sugar absorption can be delayed, postprandial blood sugar can be stabilized, sudden rising of the blood sugar can be avoided from the source, and the metabolic requirements of patients can be met. The formula is balanced in nutrition, can supplement high-quality protein, dietary fibers and trace elements, improves nutritional imbalance, is optimized by a process, is good in solubility and fine and smooth in taste, solves the problem of poor eating compliance, and is stable to store. The formula has nutrition and conditioning effects, can improve insulin sensitivity, and provides special support for both sugar control and nutrition for diabetics.

The invention relates to an inonotus obliquus fermentation product and application of the inonotus obliquus fermentation product in hypoglycemic drugs, and belongs to the technical field of inonotus obliquus fermentation products. A component culture medium is prepared from 10-15 parts of plant flour, 3-6 parts of glucose, 0.8-1.2 parts of dipotassium phosphate, 1-2 parts of magnesium sulfate, 5-8 parts of protein peptide, 4-8 parts of agar and 60-80 parts of purified water; the component B culture medium is prepared from the following raw materials in parts by weight: 12-15 parts of plant starch, 2-4 parts of glucose, 1-3 parts of oxytetracycline, 1-3 parts of chloramphenicol, 8-16 parts of sodium hyaluronate and 60-80 parts of purified water. Through the multi-target synergistic effect of improving insulin resistance, protecting islet cells, inhibiting sugar absorption and the like, the hypoglycemic effect is obvious, and the prepared inonotus obliquus fermentation product is simple in process, low in operation difficulty, suitable for industrial production and capable of being applied to the fields of cosmetics, textile industry and medicine.

The invention discloses an auricularia auricula polysaccharide-based tablet candy capable of relieving hyperglycemia and a preparation method of the auricularia auricula polysaccharide-based tablet candy, and relates to the technical field of biology, the auricularia auricula polysaccharide-based tablet candy comprises the following raw materials by weight: 20-30 parts of auricularia auricula polysaccharide; 35 to 45 parts of a filling agent; 20 to 30 parts of a disintegrating agent; 3-8 parts of a functional auxiliary material; 0.5 to 1.5 parts of a lubricant; 2-5 parts of an adhesive; wherein the auricularia auricula polysaccharide is extracted by adopting a targeted enzymolysis technology, the weight-average molecular weight is 1.0 * 10 <-2.0 > * 10 < Da >, and the bioavailability is high; the functional auxiliary material comprises an insulin secretion promoting factor and a sugar absorption inhibiting factor, and is specifically a compound of chromium yeast and a mulberry leaf extract according to a mass ratio of (1-3): 1. All the components are prepared into the tablet candy through a specific process, all the active components have a synergistic effect, and the blood sugar reducing effect can be achieved in multiple ways and multiple targets of promoting insulin secretion, inhibiting sugar absorption, improving insulin sensitivity and the like. The product is good in taste, fast in disintegration and convenient to take, can be used for preparing functional food for assisting management of type 2 diabetes, and has the blood sugar reducing effect obviously better than that of a traditional product with extracted polysaccharide or single functional factor.

The invention belongs to the technical field of tobacco additives, and provides a method for regulating and controlling the smoke concentration of tobacco leaves and a regulating and controlling agent thereof.The regulating and controlling agent comprises a first regulating and controlling stock solution used for providing a first substrate for a Maillard reaction and promoting tobacco leaf saccharide absorption and a second regulating and controlling stock solution used for providing a second substrate for the Maillard reaction and an alkaline reaction environment, wherein the first regulation and control stock solution comprises monosaccharide and a surfactant, and the second regulation and control stock solution comprises L-amino acid and a surfactant. The tobacco aroma precursor substance can be increased, the smoke concentration is increased, the style and characteristics of tobacco are improved, and the method is suitable for different aroma types of tobacco.

The application discloses a surface-engineered Gouqi-source exosome ophthalmic preparation for treating ocular surface diseases, and belongs to the technical field of ocular surface drug delivery and plant-source exosome preparation. The preparation takes Gouqi-source exosomes as the main body, takes a mucin-related peptide-anchor molecule complex capable of combining with, adsorbing, intertwining or anchoring the ocular mucosa, epithelial sugar absorption or mucin network, and having an ocular surface repair effect as a surface modification unit, and is used for improving the residence capacity of the exosomes on the ocular surface and enhancing the ocular surface repair effect.

The invention belongs to the technical field of traditional Chinese medicine tea drinks, and discloses medicinal and edible Jerusalem artichoke flower and fruit health-care tea for preventing and treating diabetes mellitus and a preparation method of the medicinal and edible Jerusalem artichoke flower and fruit health-care tea. Mulberry leaf superfine powder; a sophora flower extract; chinese wolfberry fruit microencapsulated powder; a hawthorn flavone concentrate; pericarpium citri reticulatae volatile oil microspheres; and dipotassium glycyrrhizinate. The content of inulin in the jerusalem artichoke reaches 15-20%, a beta-(2, 1) fructan structure of the jerusalem artichoke can selectively promote proliferation of bifidobacteria, and insulin secretion is adjusted through an intestine-pancreatic axis; butyric acid generated by fermentation of the jerusalem artichoke sugar can activate an AMPK channel, and the glucose uptake rate of 3T3-L1 fat cells can be increased; the synanthrin and the mulberry leaf DNJ are combined for use, so that dual targets of alpha-glucosidase (small intestine) and liver glucose-6-phosphatase (liver) can be inhibited at the same time; the synergistic effects of the helianthus tuberosus (intestinal flora regulation), the folium mori (sugar absorption inhibition), the flos sophorae (capillary protection) and the fructus lycii (beta cell repair) are integrated, so that the diabetes mellitus is really prevented and treated.

The invention provides tableted candies capable of blocking sugar absorption as well as a preparation method and application of the tableted candies, and relates to the technical field of functional foods. The tablet candy capable of blocking sugar absorption sequentially comprises an enteric-coated layer, a slow-release layer and a quick-release layer from inside to outside, the enteric-coated layer accounts for 25-35% of the total mass of the tablet candy, the slow-release layer accounts for 40-50% of the total mass of the tablet candy, and the quick-release layer accounts for 20-30% of the total mass of the tablet candy. By means of the three-layer structure, the whole-course coverage from preprandial prevention, in-meal blocking to postprandial adjustment is achieved, the action time can last for 2-3 h, and the action time is highly matched with a typical postprandial blood sugar fluctuation curve. Meanwhile, by adopting a tablet candy dosage form, the tablet candy is convenient to take and good in taste, and can be taken without water. The product is stored for 12 months under a normal-temperature sealing condition, the content of each active component is kept at 95% or above, the integrity of the microcapsule is good, and the quality requirements of commercial products are fully met.

The invention discloses a composite substitutional tea drink bag with a blood sugar reducing function and a preparation method thereof, the components of the composite substitutional tea drink bag are scientifically matched, the raw materials are synergistic, sugar absorption can be effectively inhibited, insulin resistance can be improved, and the composite substitutional tea drink bag is suitable for daily conditioning of people with high blood sugar and people with abnormal sugar tolerance; the composite substitutional tea drink bag is simple in preparation process and suitable for large-scale popularization.

The invention discloses a formula of composite fruit and vegetable powder soft sweets and a preparation process of the composite fruit and vegetable powder soft sweets. Comprising the following raw materials: 55%-60% of maltitol liquid, 12%-16% of maltitol powder, 14%-16% of polydextrose, 0.8%-1.2% of inulin, 2%-3% of fructo-oligosaccharide, 6%-7% of gelatin, 0.08%-0.12% of agar, 0.5%-1% of apple powder, 0.5%-1% of carrot powder, 0.4%-0.6% of fingered citron powder, 0.15%-0.25% of lime essence, 0.8%-1.2% of citric acid, 0.04%-0.06% of sodium copper chlorophyllin, 0.1%-0.2% of vitamin C and 0.15%-0.25% of glazing oil. According to the invention, maltitol, polydextrose and fructo-oligosaccharide are adopted to construct a sweet system, which accords with low-sugar and low-GI standards and is suitable for sugar-controlled populations such as diabetic patients and obese populations; meanwhile, polydextrose and fructo-oligosaccharide are used as soluble dietary fibers, so that sugar absorption can be delayed, and calorie intake can be reduced.

This invention discloses a food formula for stabilizing blood sugar in diabetic patients, belonging to the field of functional foods and fermentation engineering technology. The formula consists of the following ingredients in parts by weight: 15-25 parts of purple wheat bran (No. 2), 5-10 parts of soybean flour, 5-10 parts of black soybean flour, 5-10 parts of peanut flour, 10-15 parts of walnut kernel flour, 10-20 parts of purple jujube powder, 0.5-2 parts of Haematococcus pluvialis astaxanthin microcapsule powder, 0.3-1.5 parts of lutein ester microcapsule powder, 2-5 parts of *Lactobacillus plantarum* post-biotic powder, 3-8 parts of psyllium husk powder, 3-8 parts of resistant dextrin, 0.3-1 part of chromium-enriched yeast powder, 2-6 parts of pumpkin powder, 1-4 parts of shiitake mushroom powder, and 3-8 parts of purple onion powder. This invention's formula synergistically intervenes in blood sugar metabolism through multiple pathways, including protecting pancreatic β-cells, regulating intestinal flora, alleviating oxidative stress, and delaying sugar absorption. It is safe for long-term consumption without side effects, providing diabetic patients with a dietary option to help stabilize blood sugar.

The invention discloses a composition with multiple hypoglycemic mechanisms. The composition comprises a membrane separation balsam pear polysaccharide extract, a membrane separation balsam pear saponin extract, a mulberry leaf extract, a momordica grosvenori extract and inulin, the membrane separation balsam pear polysaccharide extract and the membrane separation balsam pear saponin extract have an inhibition effect on the key enzyme fructose-1, 6-diphosphatase in the gluconeogenesis path; the mulberry leaf extract and the inulin have an inhibition effect on a key enzyme alpha-glucosidase in a sugar absorption path; the momordica grosvenori extract and the inulin enhance the insulin sensitivity; the invention further discloses a preparation method of the composition with the multiple hypoglycemic mechanisms. According to the invention, through synergistic interaction of triple pathways for inhibiting gluconeogenesis, inhibiting sugar absorption and improving insulin sensitivity, a dual hypoglycemic mechanism of'blocking endogenous sugar generation from a source and inhibiting exogenous sugar absorption from a terminal 'is formed, and the hypoglycemic efficiency is obviously improved compared with that of a single mechanism formula.

In the field of biomedicine, the importance and potential value of the carbon-glycoside compounds are increasingly prominent. Carbon-glucoside widely existing in medicinal plants shows remarkable physiological activity in the aspects of oxidation resistance, inflammation resistance, bacteria resistance and the like; wherein the natural product of beta-acyl-carbon-glucoside, namely Sclerpentasides A-F, is separated from a semi-parasitic plant Dendrophthoe pentras, and is used for treating the hypertension and the diabetes mellitus in the Thailand traditional medicine, so that the Sclerpentasides A-F can be used for treating the hypertension and the diabetes mellitus. Beta-acyl-carbon-glycoside is formed by acyl and glycosyl, keto carbonyl of the beta-acyl-carbon-glycoside has potential chemical conversion capacity, and a new thought is provided for modification of existing carbon-glycoside drugs. In pharmaceutical chemistry, carbon-glycosides are often used as stable mimetics of oxygen-glycosides and nitrogen-glycosides, which are designed according to the characteristics that carbon-glycosides are used as electron isosteres of oxygen glycosides in pharmaceutical chemistry and can resist hydrolase and other decomposition pathways in vivo. A high-efficiency synthetic route is designed, and beta-acyl-carbon-glucoside can be successfully constructed through two-step reaction from sugar bromoglycoside. Wherein the beta-acyl-carbon-glucoside has excellent SGLT2 inhibitory activity, can effectively inhibit glucose absorption, and can be used for controlling blood sugar and treating diabetes mellitus.

The invention belongs to the technical field of biological medicines, and particularly relates to application of dehydroandrographolide in preparation of a medicine for treating diabetic cardiomyopathy. It is found that DA can significantly reduce the weight and blood sugar of diabetic mice and improve oral glucose tolerance tests and insulin tolerance tests. Meanwhile, cardiac hypertrophy is relieved, and cardiac output is increased. Liver metabolism and transcriptomics prompt that DA affects obesity and diabetes related metabolites, especially tyrosine metabolism. Cell tests show that DA promotes sugar absorption, and an insulin signal channel and a metabolic process are enhanced by inhibiting PTPRF protein. Actinomycete ketone and immunoprecipitation prompt that PTPRF is oxidized and degraded, and magnesium ions need to participate in the process. Cardiac transcriptome analysis shows that DA can inhibit a diabetes pathway and activate tricarboxylic acid circulation, an insulin pathway and carbon and fat metabolism.

The invention relates to the field of food health-care products, in particular to a composition with a sugar control effect, a preparation method of the composition and application of the composition to the food health-care products. Comprising the following components in parts by weight: 5-15 parts of a rhodiola rosea extract, 15-25 parts of prebiotics, 10-20 parts of a mulberry leaf extract, 20-40 parts of Chinese yam powder, 3-8 parts of vitamin B family, 1-5 parts of lipoic acid, 5-15 parts of anthocyanin and 5-15 parts of an adhesive. Through synergism of multiple components of the rhodiola rosea extract, the prebiotics, the mulberry leaf extract, the Chinese yam powder, the vitamin B family, the lipoic acid and the anthocyanin, natural plant extracts are used as main materials, and necessary synthetic nutrients are used as auxiliary materials, so that auxiliary control of blood sugar from three dimensions of inhibiting sugar absorption, regulating metabolism and protecting pancreas islet functions can be realized, and the effect of preventing and treating pancreas islet is achieved. In addition, by reducing oxidative stress and release of inflammatory factors, nerves and blood vessels can be effectively protected, and complications of diabetes mellitus can be prevented or delayed.

The present invention provides a method for preparing a hemp seed protein peptide having the effect of blocking sugar absorption and its application, belonging to the technical field of functional active peptides, comprising the following steps: crushing the hemp seed and then defatting it through a low-temperature continuous phase change to obtain defatted hemp meal after defatting, the defatted hemp meal being hydrolyzed by polysaccharidase and protease in succession, and then subjected to low-temperature salting out after the hydrolysis is completed, and then dried and sterilized to obtain the hemp seed protein peptide. The hemp seed protein peptide obtained by the technical solution and preparation method of the present invention has the following effects: 1. The hemp seed protein peptide prepared by the present invention can significantly inhibit the activity of α-amylase and α-glycosidase (the maximum inhibition rate can reach 84.2% and 75.1% respectively), thereby blocking the human body's digestion and absorption of carbohydrates such as starch, dextrin, and disaccharides. 2. The results of double-blind clinical tests show that the hemp seed protein peptide prepared by the present invention can effectively reduce the peak blood sugar level and peak area after a meal, and the effective sugar-free rate can reach 30-60%.

The invention provides double-jade sugar granules and a preparation process thereof, belongs to the technical field of sugar product preparation, and solves the technical problems that the existing double-jade sugar granules are low in preparation efficiency, cannot effectively reduce blood sugar and the like. The preparation process of the double-jade sugar granules comprises the following preparation steps: taking and adding materials; soaking raw materials; decocting for the first time; filtering for the first time and taking liquid; decocting for the second time; filtering for the second time and taking liquid; combining and concentrating; performing primary sieving; measuring the content; secondary charging and sieving; performing spray drying; granulating and finishing the granules; and packaging. The double-jade sugar granules are prepared by the preparation process. According to the process, the utilization rate of raw materials can be increased, the transfer rate of effective components of double decoction is high, the production energy consumption is low, the whole line is designed in a modularized mode, continuous production is supported, the production efficiency is high, the double-jade sugar granules can remarkably reduce postprandial blood sugar, improve traditional Chinese medicine syndromes, play a role in reducing blood sugar by adjusting the pancreas islet function, sugar absorption and metabolism utilization rate through multiple targets, and have a good application prospect. Especially, the effect on islet injury type diabetes mellitus is obvious.