The invention relates to a novel solid sterilizing and disinfecting material, and preparation and application thereof. The novel sterilizing and disinfecting material is prepared from the following main raw materials: quaternary ammonium salt, polyamine, cetanol polyethylene ether and guanidine salt; the novel sterilizing and disinfecting material can quickly kill all bacteria and viruses in surroundings within a short time by a purely physical method, the whole process is quick, clean and complete, and the purely physical process does not have any toxic or side effect; the novel sterilizing and disinfecting material can be widely applied to the fields of medical and health industry, food packaging and refreshing industry, aquaculture industry, aquarium fish and landscape water treatment, sterilization and disinfection of silkworm breeding utensils and the surroundings, long-range fishing operation, water treatment industry, aerospace and the like; the novel sterilizing and disinfecting material can be produced into many products having significant impacts on human life and production, such as nonwoven fabric, a filter screen, a film, a respirator, a sanitary napkin, underwear, socks, patient clothes, beddings and water pipes with excellent bactericidal performance.