36results about How to "Reduced scavenging" patented technology

The invention discloses a tumor microenvironment response nanoparticle based on peptides dendrimer modified fluorescence carbon dots. A preparation method of the tumor microenvironment response nanoparticle comprises the following steps: (1) preparation of nanometer fluorescence carbon dots; (2) surface sulfhydrylation modification of the fluorescence carbon dots; (3) preparation of second-generation peptides dendrimer grafted by arginine-lysine; (4) surface modification of the second-generation peptides dendrimer with fluorescence carbon dots; (5) preparation of a zwitterionic polymer polycarboxylate betaine methacrylate; (6) preparation of drug-loading carbon dots; (7) preparation of a drug-loading nanoparticle. The drug-loading nanoparticle prepared with the method has the specific fluorescent property of the carbon dots and dual high-sensitive responsiveness for an acid environment of a tumor site and high-concentration glutathione, high-selectivity rapid drug release in tumor cells can be achieved, and the drug-loading nanoparticle is high in anti-tumor efficiency and good in safety; in addition, integration of diagnosis and treatment of tumors is expected to achieve.

The invention discloses deer blood wine and a preparation method of the deer blood wine and belongs to the technical field of nutritional Baijiu. Fresh deer blood and deer whips are used as main raw materials and are scientifically compounded with lycium ruthenicum, fructus lycii, mulberry fruit, fructus jujubae, longan, liquorice root and the like; a whole process adopts low-temperature processing technologies of freeze-drying, carrying out biological enzymolysis by a complex enzyme, degassing and deodorizing in vacuum, freezing, carrying out low-temperature fermentation by functional saccharomyces cerevisiae, carrying out ultrasonic processing, carrying out high-voltage pulse electric field processing and the like; the utilization rate of effective components of deer products is effectively improved, and the loss of nutrients and health-care substances is reduced; the original color and luster, flavor and the content of bioactive components and nutrient substances of the deer products are kept to the greatest extent. Finally, the deer blood wine which has no odor, high stability, coordinated taste, mellowness, softness, long aftertaste, moderate flavor, high bioactive components and nutrient value and good health-care effect and is clarified and transparent is prepared.

The invention relates to a polyelectrolyte modified graphene oxide anti-cancer drug preparation and a preparation method thereof. The method comprises the following steps: utilizing a charge attracting principle to respectively coat poly allylamine hydrochloride PAH with positive charges, polyacrylic acid PAA with negative charges and cysteine CYs onto a graphene oxide GO surface loaded with an anti-cancer drug and lastly acquiring PAA-CYs / PAH-GO-X. The preparation provided by the invention is coated with two layers of polyelectrolyte, so that the drug can be protected under a strong acidic environment and ultrahigh strong acid resistance stability is represented; the surface is coated with the PAA-CYs, so that the drug preparation is adhered to the inner wall of intestinal tract and a better intestinal absorption effect is achieved; in vitro release and pharmacokinetics prove the preparation has a certain slow release effect; a drug carrier system provided by the invention can effectively promote the orally taken bioavailability of the anti-cancer drug, can be applied to anti-cancer research and has ultrahigh application value for clinical research.

The invention discloses an air conditioner comprising a dust catch filter interposed between an inlet and a heat exchanger, a cleaning unit (5) for removing dust caught by the filter, and filter driver (18) for reciprocally driving the filter with respect to the cleaning unit (5). The cleaning unit (5) has a dust box (21) having a cleaning brush for removing dust caught on the surface of the filter and a filter hold plate that is attached to the dust box (21) and that holds a rear surface of the filter. The air conditioner is provided with cleaning brush driver (20) that draws the cleaning brush from the dust box (21) and brings the cleaning brush into contact with the filter during cleaning of the filter and that separates the cleaning brush from the filter and puts the cleaning brush in the dust box (21) when the filter is not cleaned.

The invention discloses low-fat low-lipide-digestibility artificial butter. The low-fat low-lipide-digestibility artificial butter comprises the following components in parts by weight: 20-70 parts ofmicronized whey protein dispersed liquid, 10-30 parts of a xanthan gum system, and 10-60 parts of oil phase. The artificial butter not only has the characteristic of being low in fat (10-60%), but also can restrain contact of lipases and oil drops in digestive tracts of human bodies, and can prevent free fatty acids from being released, so that the lipide digestibility can be reduced. According to a method, whey protein and xanthan gum are used as raw materials, and damp and hot treatment, a micronizing technique, a compounding technique and an emulsifying homogenizing technique are adopted for preparing oil in water emulsion. The digestion suppression ratio of the artificial butter for lipide is as high as 60%. The low-fat low-lipide-digestibility artificial butter has smooth and soft mouth feel of butter, and white fine and smooth appearance, has similar processing characteristics of plasticity, stability and the like as cream sold in the market, and can be widely applied to processing of various foods through replacing cream.

The invention relates to a separation and purification method of a Basidiomycetes antifungal component; the antifungal component is composed of two amide-type substances, and the molecular weight of the two substances is 5732.39 and 7187.01; the separation and purification process comprises the following steps: Basidiomycetes entity authentication, strain separation and purification, strain identification, mycelium liquid culture, antifungal component extraction, antifungal component separation, antifungal component purification. The method can inhibit chrysosperma mycelium growth and spore germination with 100 percent of inhibition rate, and has obvious inhibiting function to Pinus sylvestris germ at the same time. The Basidiomycetes antifungal substance affects the activity of seven enzymes of pathogenicbacteria, reduces the activity of hexokinase, improves the activity of pyruvate kinase, succinic acid, lactate dehydrogenase and ATP enzyme, and speeds up the respiration of germs.

The invention discloses a preparation method of a fruit / vegetable pesticide residue purification microbial inoculant. The preparation method comprises the following steps: after culturing a lactobacillus strain, carrying out centrifugal cleaning, and adding a sodium chloride water solution, wherein the lactobacillus strain is collected by China General Microbiological Culture Collection Center (CGMCC for short), and the collection number is CGMCC No.10574. The sodium chloride solution added into the lactobacillus strain can reduce the damage of low temperature to the strain, and can also inhibit growth of the lactobacillus. The strain is easy to control and convenient and easy to acquire. The microbial inoculant has the advantages of low production cost, high safety, no harm and favorable pesticide residue purification effect.

The present invention relates to a method for extracting anthocyanin from yin-fragrant fruit, including the following steps: (1) to put the yin-fragrant fruit in a vessel, adding water until submerging the fruit, to heat until boil and take out, to cool until room temperature, to beat so as to make the sarcocarp and fruit stone to separate; (2) to add the yin-fragrant fruit and the fruit stone into alcohol solution, and to regulate the pH value of the mixing liquid, dipping beating, filtering and collecting filtering liquid; (3) to decompress and distill the filtrate so as to recover alcohol solvent, to make the alcohol chroma of the filtrate decrease until 10 percent, then to fetch clear liquid after placing whisht, to obtain yin-fragrant anthocyanin extracting liquid; (4) to absorb and separate the yin-fragrant anthocyanin extracting liquid with big-holes adsorption resin, to wash with alcohol solution, at the same time to collect washing liquid to decompress and dry, to produce powder shape yin-fragrant fruit anthocyanin. The yin-fragrant anthocyanin pigment has high stability, stable anti-oxidation activity and simple technics as well as raw material has low cost.

The invention provides a novel bionic nano material for sonodynamic / gas synergistic anti-tumor treatment. Gold nanoparticles (AuNPs) are loaded in situ by using black phosphorus quantum dot hybrid mesoporous silicon nanoparticles, and CO gas prodrug molecules CORM-401 are loaded by using rich porous structure advantages of the gold nanoparticles, and a macrophage membrane is further used for wrapping to obtain the bionic nano material N-coated CAu-BMSN. The utilization of the macrophage membranes in the bionic nano-material can effectively avoid the phagocytosis and removal effects of macrophages in vivo on N-coated CAu-BMSN, and improve the enrichment of the nano-material in a tumor area; and meanwhile, under the intervention of local ultrasonic waves, CO gas and 1O2 can be effectively generated in tumor cells in situ by the nano-material core and are used for inducing tumor cell apoptosis and activating an organism immune system, thereby realizing sonodynamic / gas synergistic anti-tumor treatment.

The invention provides polymer nanoparticles double-loaded with docetaxel and flavonoid compounds. The polymer nanoparticles, with a PEG-PCL material as a carrier, are loaded with docetaxel and flavonoid compounds, thereby realizing slow-release of drugs in vivo, reducing drug resistance of tumors, and reducing the dosage of the drugs. The invention further provides a method for preparing the polymer nanoparticles double-loaded with docetaxel and flavonoid compounds, and the method has the characteristics of simple process and relatively high yield. The polymer nanoparticles have considerableprospects in the application of antitumor drugs.

The invention belongs to the technical field of resource and environment protection, and in particular relates to an algae pond-constructed wetland-ecological pond environment-friendly treatment method for tail water of urban sewage treatment plants, the tail water of urban sewage treatment plants roughly flows through an algae pond, a constructed wetland and an ecological pond in sequence, and organisms in the algae pond comprise algae which can directly utilize hydrophilic components of dissolved organic matters in the tail water and bacteria which convert hydrophobic components of the dissolved organic matters in the tail water into forms usable by the algae. The constructed wetland comprises a pond body, the pond body is filled with a matrix, aquatic plants are also planted in the wetland, and an ecological floating bed is constructed in the ecological pond.

The invention discloses a scenic spot introduction display device for agricultural sightseeing tour. The scenic spot introduction display device structurally comprises an automatic and rapid display mechanism, a display board, two fixed frames, a connecting seat and self-locking castors, wherein the cross sections of the automatic and rapid display mechanism and the display board are respectivelyof a rectangular structure; the back end of the display board is fixedly buckled at the surface of the front end of the automatic and rapid display mechanism, and forms an integral forming structure with the automatic and rapid display mechanism; the two fixed frames are horizontally welded at both sides of the lower end of the automatic and rapid display mechanism. The scenic spot introduction display device has the advantages that the protection effect on a display cloth is improved; under the cooperation function of a drive motor, a screw rod, an adjusting rod and a hollow groove, the height can be adjusted according to the use and display requirements, and the comfortability in tour is higher; when the display cloth is cleaned, the effect of clearing dust near the display cloth in theproduct display process can be realized under the cooperation functions of the bearing block, a second motor, a rotary shaft and fan blades, the product is further protected, the quality of the display cloth is improved, and the troublesome of a worker is reduced.

The invention provides application of a compound preparation of ascorbic acid and metformin in preparing a chemotherapeutic drug. The mass ratio of the ascorbic acid to the metformin is (1.76 to 3.52)to (1.66 to 6.62). In an application solution of the compound preparation, the concentration of the ascorbic acid is 10mmol / L to 20mmol / L, and the concentration of the metformin is 10mmol / L to 40mmol / L. The compound preparation provided by the invention integrates the ascorbic acid and the metformin so as to be used as the chemotherapeutic drug for high-efficiently killing tumor cells, so that achemotherapeutic effect is improved. The chemotherapeutic drug provided by the invention not only has a higher inhibiting effect on tumor cells and higher selectivity, and is less in damaging normal cells, but also can be beneficial to great reducing of patient hospitalizing cost due to cheap prices of the two medicines; the invention provides the safer and more effective chemotherapeutic drug with a higher popularization value.

The invention provides an antiscale agent for a brine transportation pipeline. The antiscale agent is prepared from starch phosphate, sodium lignin sulfonate, gluconic acid-malic acid-sodium pyrophosphate telomere and purified water according to a certain proportion. When the antiscale agent is used by three domestic salt plants, it is proved that undissolved salt crystals can be effectively prevented from being produced by high-concentration Ca2+ and Mg2+ in original brine after the antiscale agent is added to the original brine conveyed by the pipeline, and therefore it is avoided that when scales are produced by Ca2+ and Mg2+ in the pipeline for conveying the original brine, brine is not smoothly conveyed by the pipeline, the brine conveying resistance is eliminated, the brine mobility is improved, the brine conveying efficiency is effectively improved, and energy consumption is lowered; after long-term use, the agent has a certain effect on cleaning away existing scales. Meanwhile, non-toxic and harmless food additives are selected as the raw material, the residual antiscale agent in finished salt only accounts for one thousandth of the permissible dose in food, and human health is not influenced after the antiscale agent is eaten.

The invention relates to a drug composition for treating multiple sclerosis, in particular to a nasal glatiramer acetate gel composition. The drug composition is prepared from glatiramer acetate, gel substrate and pharmaceutically acceptable auxiliary materials, wherein other acceptable auxiliary materials comprise 0.9%-1.75% of bio-adhesive materials, and the bio-adhesive materials are one or more of starch, chitosan, glucan, and xanthan gum.

The invention relates to a cream cosmetic, which adds quinoa composition prepared from quinoa as raw material, and reacts quinoa protein with dextran to make the cream cosmetic break through the effect of adding quinoa polypeptide traditionally, has high efficiency of scavenging free radicals, and has excellent performance in anti-aging performance.

The invention discloses a traditional Chinese medicine compound composition with an anti-fatigue function and application of the traditional Chinese medicine compound composition. The traditional Chinese medicine compound composition with the anti-fatigue function is prepared from rhodiola rosea, polygonatum kingianum, hairyvein agrimony, ginger, cassia twig and broadleaf holly leaf according to a certain weight percentage. The traditional Chinese medicine compound composition has an obvious effect on improving energy, and is a safe and effective dietary supplement.

Methods and systems are provided for adjusting amount of directly injected fuel scavenged via a second exhaust manifold of a split exhaust engine system. In one example, a method may include adjustinga start of injection of a fuel direct injection into an engine cylinder, the cylinder including a first exhaust valve coupled to a first exhaust manifold and a second exhaust valve coupled to a second exhaust manifold, the second exhaust manifold coupled to an intake of the engine, based on a closing timing of the second exhaust valve and dependent on an operating condition, and adjusting a position of a bypass valve of the second exhaust manifold based on the adjusted start of injection. In this way, the amount of scavenged fuel may be increased or decreased based on the operating condition.

The present invention provides a novel biomimetic nanomaterial for acoustic power / gas synergistic anti-tumor therapy, which mainly utilizes black phosphorus quantum dot hybrid mesoporous silicon nanoparticles to load gold nanoparticles (AuNPs) in situ, and utilizes Its rich pore structure is advantageous for loading CO gas prodrug molecule CORM‑401, and further using macrophage membrane for coating to obtain the biomimetic nanomaterial N@CAu‑BMSN. The utilization of the macrophage cell membrane in the biomimetic nanomaterial can effectively avoid the phagocytosis and clearance of N@CAu‑BMSN by macrophages in the body, and improve the enrichment of the nanomaterial in the tumor area; at the same time, under the intervention of local ultrasound, the nanomaterial The inner core can effectively generate CO gas in situ in tumor cells and 1 o 2 It is used to induce tumor cell apoptosis, activate the body's immune system, and realize sonodynamic / gas synergistic anti-tumor therapy.

The invention provides a micro-environment response type nano composite material for efficiently removing tumor cells as well as a preparation method and application of the nano composite material. According to the nano composite material disclosed by the invention, iron oxychloride nano points (FeOCl NDs), doxorubicin (DOX) and bovine serum albumin (BSA) are loaded on polymer nanogel (PAD), so that the PAD-coated FeOCl / DOX-BSA nano composite material, which is called PFDB for short, is prepared. The material can be degraded under the action of excessive glutathione (GSH) in a tumor microenvironment, and FeOCl NDs and DOX are released. FeOCl NDs can catalyze H2O2 to generate hydroxyl radicals (OH) with strong oxidizing property to damage tumor cells; dOX can realize chemotherapy of tumors and synergistically enhance the treatment effect. The PFDB provided by the invention not only can effectively inhibit and remove tumor cells, but also has good colloidal stability and biological safety. In conclusion, the invention provides the tumor microenvironment response type nano composite material, and the efficient removal of tumor cells can be realized.

The invention discloses a degradable cleansing tablet material for a removable denture. The degradable cleansing tablet material is prepared from the following raw materials: dandelion extract, triethyl citrate, polyethylene glycol, polysorbate, polyvinyl pyrrolidone, sodium alginate, xanthan gum, cyclodextrin, hydroxymethyl cellulose, methyl p-hydroxybenzoate, propionyl glycerol monopalmitate, radix puerariae arrow root powder, sodium citrate, sodium pyrophosphate, natrium aceticum, sodium stearyl fumarate, tea extract and quicklime powder. The degradable cleansing tablet material for the removable denture disclosed by the invention is an anti-bacterial stain removal denture cleansing tablet material which is high in cleaning efficiency, quick in disintegration time, cheap in price and elegant in fragrance, and can quickly and effectively remove dirt and bacteria from the removable denture.

The invention discloses the use of hsa-miRNA-423-5p in the preparation of an autophagy maturation inhibitor, and the use of the hsa-miRNA-423-5p inhibitor in the preparation of a drug for treating tuberculosis. The expression level of hsa-miRNA-423-5p provided by the present invention in the serum of tuberculosis patients is significantly higher than that of healthy controls, and it is confirmed that when hsa-miRNA-423-5p is highly expressed, it can lead to obvious autophagy maturation blocking phenomenon; hsa When the expression of ‑miRNA‑423‑5p is inhibited, the phenomenon of autophagy maturation inhibition is relieved. Therefore, hsa‑miRNA‑423‑5p can be used as a good target for the treatment of tuberculosis. Moreover, hsa-miRNA-423-5p is a small molecule that exists by itself, so it is superior to chemical drugs in terms of side effects, and will not cause drug-resistant tuberculosis due to repeated medication.

The invention discloses a mica air guide purification and noise reduction wallpaper. The mica air guide purification and noise reduction wallpaper comprises a bottom layer and a pattern layer, wherein the pattern layer is arranged on the bottom layer. The mica air guide purification and noise reduction wallpaper is characterized in that an air guide layer is arranged below the pattern layer, the air guide layer is formed by arranging multiple rows of air guide holes, a glue surface layer is arranged on the pattern layer, a sand grain layer is arranged on the glue surface layer, an air purification layer is arranged on the sand grain layer, an adhesive sticker layer is arranged below the bottom layer, a release paper layer is arranged below the adhesive sticker layer, the bottom layer is made of mica sheet material, the glue surface layer is 0.4mm in thickness, the air purification layer is made of photocatalyst, the air purification layer is 0.3mm in thickness, the bottom layer is 0.2mm in thickness, and each air guide hole is 0.03mm in radius. The mica air guide purification noise reduction wallpaper is good in electrical insulating property, poor in electrical conductivity, high in security coefficient, high in removal efficiency and long in efficacy time, easily discharges bubbles, has a sound absorption and noise reduction function, enables a habitant to feel comfortable, and can purify indoor air.

The invention relates to a method for preparing a spice salt for inhibiting the oxidation of salted preserved duck. The method comprises the following steps: 1) pulverizing a mixed spice of flos caryophylli, 20%-30% of galangal, pepper and netmeg, sieving, adding an ethanol solution, the weight of which is 10 to 30 times the weight of the spice powder, soaking at 30 to 80 DEG C for 2-5 hours, andcarrying out pressure filtration, so as to obtain spice extract liquid; 2) adding the spice extract liquid, the weight of which is 1 to 6 times the weight of salt, into the salt, separately adding beta-cyclodextrin, the weight of which accounts for 2% to 10% of the weight of the salt, and maltodextrin, the weight of which accounts for 2% to 10% of the weight of the salt, into the salt, heating forconcentrating, recovering ethanol, and heating while stirring until moisture is totally dried and the material is completely crystallized, so as to obtain a spice salt cocrystallized embedding material; and 3) crushing and sieving. The method can effectively prevent the loss of antioxidant components in spices, active components can be evenly distributed on the surface of a duck body along with the salt and the salt penetrates into the duck body fast, the surface of the duck body has no fines of spices and does not need to be cleaned, and thus the standardized green production of salted preserved duck is easy to be realized.

The invention discloses an adsorption enhanced dialyzer. The adsorption enhanced dialyzer comprises a hemodialysis cavity (1), wherein a plurality of first hollow fiber membrane filaments (2) and a plurality of second hollow fiber membrane filaments (3) are arranged in the hemodialysis cavity (1), and the membrane flux of the second hollow fiber membrane filaments (3) is larger than that of the first hollow fiber membrane filaments (2). By applying the technical scheme provided by the embodiment of the invention, macromolecular substances in a patient are removed by improving the adsorption effect in the hemodialysis process of the patient; meanwhile, a perfusion device does not need to be additionally adopted, additional replacement liquid does not need to be added, the extracorporeal circulation blood volume of the patient can be reduced while the burden of the patient is relieved, and the cardiovascular burden of the patient is relieved; and besides, due to the internal filtration performance of the high-performance dialyzer, the problem that the flux of the specially-made adsorptive hollow fibers is reduced is effectively delayed, and the capacity of the dialyzer for scavengingmedium-molecular and macromolecular substances is enhanced.

The invention discloses a method of refining ambroxol hydrochloride for injection; the method comprises the steps of heating crude ambroxol hydrochloride with hydrochloric acid solution, reflux-dissolving, filtering, recrystallizing filtrate, washing, and drying to obtain the ambroxol hydrochloride for injection. The method is simple to perform, low in cost, high in product purity and high in yield, impurities B can be effectively removed, the content of other single impurities can also be controlled to 0.01% and below, and all yields reach 90% and above.

The invention provides an antiscale agent for a brine transportation pipeline. The antiscale agent is prepared from starch phosphate, sodium lignin sulfonate, gluconic acid-malic acid-sodium pyrophosphate telomere and purified water according to a certain proportion. When the antiscale agent is used by three domestic salt plants, it is proved that undissolved salt crystals can be effectively prevented from being produced by high-concentration Ca2+ and Mg2+ in original brine after the antiscale agent is added to the original brine conveyed by the pipeline, and therefore it is avoided that when scales are produced by Ca2+ and Mg2+ in the pipeline for conveying the original brine, brine is not smoothly conveyed by the pipeline, the brine conveying resistance is eliminated, the brine mobility is improved, the brine conveying efficiency is effectively improved, and energy consumption is lowered; after long-term use, the agent has a certain effect on cleaning away existing scales. Meanwhile, non-toxic and harmless food additives are selected as the raw material, the residual antiscale agent in finished salt only accounts for one thousandth of the permissible dose in food, and human health is not influenced after the antiscale agent is eaten.

The invention discloses a preparation method of a fruit / vegetable pesticide residue purification microbial inoculant. The preparation method comprises the following steps: after culturing a lactobacillus strain, carrying out centrifugal cleaning, and adding a sodium chloride water solution, wherein the lactobacillus strain is collected by China General Microbiological Culture Collection Center (CGMCC for short), and the collection number is CGMCC No.10574. The sodium chloride solution added into the lactobacillus strain can reduce the damage of low temperature to the strain, and can also inhibit growth of the lactobacillus. The strain is easy to control and convenient and easy to acquire. The microbial inoculant has the advantages of low production cost, high safety, no harm and favorable pesticide residue purification effect.

The invention discloses a removal device for adhering sand in a mold cavity of a pig iron casting. The removal device comprises an ignition box body, and a motor room is arranged at the center of thebottom wall of the ignition box body. A motor and a driving shaft are arranged in the motor room, and the top of the driving shaft is fixedly connected with a rotating sieve plate. A heating plate isarranged on the bottom wall of the ignition box body, and an igniter, a gasoline pipe, a suck-back water pipe and a drain pipe are arranged on the side wall of the ignition box body in sequence. The suck-back water pipe and the drain pipe communicate with a water storage box, and the gasoline pipe is connected with a pressure pump and the bottom position of a gasoline tank. A sealing cover body isarranged at the top of the ignition box body. The removal device is specially aimed at the difficult problem that the adhering sand on the inner wall of the casting with a complex mold cavity structure cannot be cleaned. The gasoline is fully infiltrated into the surface of the casting and then is ignited to carbonize grease on the surface of the casting, so the adhesion between the adhering sandand the surface of the casting is greatly reduced. Moreover, the negative pressure phenomenon during fire extinguishing is utilized to enable the suck-back water pipe to wash and cool the casting, sothe removal efficiency and removal effect of the adhering sand are greatly reduced, and the cleanliness of the inner part of the mold cavity of the casting is ensured.

The invention discloses a preparation method of a proton exchange membrane. The preparation method of the proton exchange membrane comprises the following steps: grafting hindered amine onto the surface of unmodified carbon quantum dots to obtain hindered amine modified carbon quantum dots; The hindered amine-modified carbon quantum dots, the perfluorosulfonic acid resin and the alcohol solution are uniformly mixed to obtain a polymer slurry; according to the polymer slurry, a proton exchange membrane is obtained. The invention grafts hindered amine and perfluorosulfonic acid resin on the basis of unmodified carbon quantum dots, and can prepare a proton exchange membrane with strong oxidation resistance, thereby improving the chemical stability and service life of the proton exchange membrane.