The invention discloses efficient bio-organic fertilizer which comprises straw, livestock excrement, leftovers, winery sewage, lees, bagasse, discarded traditional Chinese medicine, mildewed grain, magnesium nitrate, egg shells, waste paper, wheat bran, rape seed cake, bean pulp and strains. The efficient bio-organic fertilizer is free from toxicity, harmless, environmentally friendly and antibacterial, prevents diseases, and can improve and repair soil, increase organic matter of soil, improve the water and fertilizer preserving ability of the soil, increase the yield, prevent water from being polluted and protect environment; waste is used as a raw material, the problem of environmental pollution caused by industry, agriculture and life garbage is reduced, the waste is turned into wealth, nutritional ingredients of the organic fertilizer can be increased, crops grow well, and the yield and the nutritional ingredients of the crops are increased; multiple compound bacteria are fermented to form the fertilizer, the content of effective living bacteria is high, fermentation time is shortened obviously, working efficiency is improved, the multiple bacterial strains grow coordinately, and the shelf life can be prolonged to be 5 years.