The invention relates to a medicine composition for treating respiratory tract infection and application thereof. The medicine composition is prepared from lasiosphaera seu calvatia, Aristolochia debilis Sieb. et Zucc, Fibraurea recisa Pierre, Asparagus cochinchinensis(Lour.)Merr, liquorice roots, Terminalia chebula Retz, dandelion, scutellaria baicalensis, Forsythia suspense, radix isatidis, mulberry twigs, shaddock ped, pepper, folium artemisiae argyi, Agastache rugosa (Fisch. et Mey.)O. Ktze, fortune eupatorium herb, dahurian angelica roots, tangerine peel, poria cocos, endothelium corneum gigeriae galli, hawthorn, ginger, schizonepetae herba, divaricate saposhnikovia roots, Heracleumhemsleyanum, Bupleurum chinense, rhizoma chuanxiong, fructus aurantii, balloon flowers, Areca catechu L. and Trichosanthes kirilowii Maxim.. The medicine composition is a traditional Chinese medicine preparation, traditional Chinese medicines which are gentle in flavor are carefully selected, unpleasant tastes of the traditional Chinese medicine cover one another, the taste is good for patients, and the compliance of patients is improved.