142 results about "Known Coronary Artery Disease" patented technology

The invention discloses a non-invasive central aortic blood pressure measuring method and device. The non-invasive central aortic blood pressure measuring method includes, according to a human artery network model based on viscous fluid mechanics, a method of calculating artery network model personalized parameters of a measured person through measured radial artery and brachial artery pulse wave signals and arm blood pressure values, a method of calculating an ascending aorta-radial artery transfer function and a method of calculating central arterial pressure waveforms through measured central arterial pressures. The non-invasive central aortic blood pressure continuous measuring device comprises a pulse wave signal processing and analysis unit and a radial artery and brachial artery pulse wave signal acquisition unit worn on a wrist. The method is different from an existing general transfer function method, the artery network model parameters of each person to be measured are measured and calculated and the artery network model parameters are numerical characteristics of the cardiovascular system states of the person to be measured with the calculated central arterial pressure waveforms, and the method and device has important meanings in prevention, curing and control of cardiovascular diseases, especially high-risk diseases, such as hypertensions and coronary heart diseases.

The invention discloses health-care vinegar which is prepared from the following preferable raw materials of barbary wolfberry fruits, honeysuckle flowers, dates, momordica grosvenori, ginger, hawthorns, licorice roots, mint and red-rooted salvia roots by the following steps of: pulverizing; adding water to soak; decocting; filtering decocted liquid; adding table vinegar to the liquid with a total weight part; fermenting; adding white sugar and a food additive; and sterilizing at high temperature, wherein the table vinegar is rice vinegar produced by the enterprise or Zhenjiang spiced vinegar (mature vinegar), and the food additive is potassium sorbate. The health-care vinegar is convenient to prepare and has the health-care effects of improving the immune competence, sterilizing, diminishing inflammation, digesting, reducing the blood pressure and the blood sugar, preventing coronary heart diseases and diabetes, and the like.

The invention provides mulberry leaf and tartary buckwheat fine dried noodles. The mulberry leaf and tartary buckwheat fine dried noodles are prepared from 55-70 parts by mass of tartary buckwheat flour, 15-30 parts by mass of wheat gluten, 5-15 parts by mass of high gluten wheat flour, 3-10 parts by mass of mulberry leaf powder, 0.5-1.5 parts by mass of edible salt, 0.3-0.7 part by mass of sodium carbonate, 0.1-0.3 part by mass of konjac gum, 0.1-0.3 part by mass of xanthan gum and 35-42 parts by mass of drinking water. A preparation method of the mulberry leaf and tartary buckwheat fine dried noodles comprises the processes of preparation of a noodle improver solution, dough kneading, ripening, tabletting, drying, packaging and the like. The products are unique in formula, have excellent taste, are rich in nutrients, have prominent health care functions and are suitable for all kinds of people to eat, especially patients with constipation, obesity, diabetes mellitus, hypertension and coronary heart diseases.

The invention discloses an application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy, which can be used for treating vascular nerve cephalalgia, cerebral thrombus, cerebrovascular angiosclerosis, coronary heart diseases, angina pectoris, hypertension, or asomnia, or common cold, or women's dysmenorrheal.

A method of treating or inhibiting depression in a patient with cardiovascular disease, especially a patient suffering from coronary artery or vascular disease, the method including administering, preferably orally, to the patient a therapeutically effective amount of an essential fatty acid composition comprising preferably more than 25% by weight of eicosapentanoic acid ethyl ester (EPA), of docosahexaenoic acid ethyl ester (DHA), or of a mixture of eicosapentanoic acid ethyl ester (EPA) and docosahexaenoic acid ethyl ester (DHA), especially a mixture of EPA and DHA in an EPA / DHA ratio in the range from about 0.9 to about 1.5 at a dosage of from about 0.7 g to about 6 g per day.

The invention discloses a method for preparing edible salt added with froggrass. Healthcare salt comprises commercial salt as a main ingredient and froggrass as a healthcare ingredient. The method comprises the following steps: drying commercial salt, adding a certain amount of froggrass into the salt, uniformly stirring, adding a certain amount of dextrin and seasonings into the salt, adding a proper amount of an anti-caking agent into the salt according to different needs, and performing subsequent operations of adding iodine, packaging and the like. The method is simple; the produced functional healthcare salt can be used for effectively overcoming the disadvantage of high possibility of diseases such as hypertension and coronary heart diseases due to excessive intake of sodium in traditional salt and bringing a healthcare effect of the froggrass into play to the hilt while ensuring a seasoning effect; the salt prepared by using the method is suitable for being used by various people.

The invention relates to the field of medicine synthesis and discloses an exenatide analog. The exenatide analog disclosed by the invention is used for preparing a medicine composition for treating diseases. The invention discloses application of medicine composition in preparing medicines for treating at least one of the following diseases: type-II diabetes, impaired glucose tolerance, type-I diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive disorder, atherosclerosis, myocardial infarction, coronary heart diseases, cardiovascular diseases, stroke, inflammatory intestinal tract syndrome and / or dyspepsia or gastric ulcer, hepatic fibrosis diseases and pulmonary fibrosis diseases.

The invention relates to an imaging method and a device for visualizing coronary heart disease, in particular cardiac infarction lesions, in which at least one image of the heart or heart region comprising at least the myocardium is recorded and reproduced using computed tomography part. The method is characterized in that, by windowing the measured data of the image or the data derived therefrom in the region of the myocardium, regions with insufficient blood supply and / or damage are segmented and displayed in the image in a distinctive manner. In particular, the method according to the invention and the associated device can be used to graphically display the extent of damage after a heart attack.

The invention provides combinations of multiple genetic single nucleotide polymorphism sites related to individualized medication of statins and application thereof. The combinations specifically comprise combinations of multiple genetic single nucleotide polymorphism sites respectively related to individual risks of coronary heart diseases, individual sensitivity to pharmacological action of statins on lowering of cholesterol (LDL-C) and individual susceptibility to adverse reaction of statins. The invention also provides a detection method directed at the combinations of the single nucleotide polymorphism sites and application of the combinations to construction of three-dimensional detection apparatuses and assessment and treatment apparatuses used for predicating and assessing individual risks of coronary heart diseases and statin intervention earnings, sensitivity to pharmacological action and dosage adjustment, and susceptibility to adverse reaction and management and control.

The invention provides a rosa davurica total flavone extract, its extracting method and its medical use, and relates to a traditional Chinese medicine extract in effective medical parts, an extracting method thereof and the medical use thereof. The invention comprises the following steps: drying and crushing traditional Chinese medicine rosa davurica and performing a heat backflow extraction by 65% to 75% of ethanol, putting an extraction solution into 30 to 60 meshes of polyamide column, washing to colorless and eluting with ethanol of the concentration of 65 to 75 %, collecting an eluent and recovering ethanol to obtain raw material medicines used for the research of new medicines of traditional Chinese medicine. According to the invention, the total flavone content in the extract detected by using an UV spectrophotometry method is more than 50%. The rosa davurica total flavone extract which is extracted and purified by the invention has the functions of treating coronary heart diseases, cardiac muscle ischemia, arrhythmia, hyperlipidemia and the like.

The present invention relates to a method for establishing a diagnosis if an individual has suffered from or a prognosis if an individual is at risk of suffering from a coronary heart event, which method comprises determining the concentration of sCD40L in a body fluid of the individual; determining the concentration of a proximal inflammatory marker, preferably PAPP-A or Lp-PLA2 comparing the values obtained with reference values; and establishing the diagnosis or the prognosis in respect to the cardiovascular event. The combination according to the invention can be used with further markers selected from further inflammatory markers, anti-inflammatory markers and / or neurohumoral markers.

The invention provides a micro RNA group related to Th17 differentiation. The micro RNA group comprises micro RNA 4426, micro RNA 3615, micro RNA 106b, micro RNA 590 and micro RNA 573. The micro RNA changes remarkably in the Th17 differentiation process and can be used as Th17 control targets for preparing drugs for treating or preventing Th17-related diseases including lupus erythematosus, dermatomyositis, vasculitis, sicca syndromes, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, scleroderma, multiple sclerosis, malaria, solar dermatitis, eczema, leucoderma, psoriasis, atopic dermatitis, lichen planus, diabetes, coronary heart diseases, hyperlipemia and the like. The micro RNA group is sensitive to hydroxychloroquine intervention and can serve as a sensitive index for judgment of the clinical effect of hydroxychloroquine, and the micro RNA is convenient to test clinically and can be rapidly used for judging the clinical effect of hydroxychloroquine.

The invention discloses a human myeloperoxidase enzyme activity and total quantity detection kit, a detection method and a preparation method. The detection kit comprises a solid-phase carrier, a zymolysis substrate, buffer solution, an enzyme antibody reagent, a plurality of calibration products, cleaning solution, a chromogenic substrate and stop solution, the solid-phase carrier is coated with 200-400ng / hole of anti-MPO (myeloperoxidase) non-restraining antibodies, the zymolysis substrate comprises 0.1-50mmol / L of H2O2, the enzyme antibody reagent contains anti-MPO (myeloperoxidase) restraining antibodies marked by horse radish peroxidase, the usage amount of the antibodies is 1:2000-1:8000, the antigen content of myeloperoxidase of the calibration products is 0-1000ng / ml, the chromogenic substrate at least comprises chromogenic substrate A solution and chromogenic substrate B solution, the chromogenic substrate A solution contains 0.015-0.02% of peroxide, and the chromogenic substrate B solution contains 0.25-0.32g / L of TMB (tetramethylbenzidine). According to the detection kit, the conditions of the myeloperoxidase in human bodies can be accurately responded, and the detection kit provides more accurate basis for clinical diagnosis and early warning of coronary arteries diseases, particularly, and unstable coronary heart diseases.

The invention discloses placebo for coronary heart disease and a preparation method thereof. The placebo contains malto dextrin, caramel pigment, sunset yellow pigment, tartrazine, sucrose octaacetate, tangerine essence, agastache rugosus essence, Beta-cyclodextrin and non-decoction coronary heart disease particles. The preparation method comprises the following steps: taking the Beta-cyclodextrin and adding water for dissolving, then adding the tangerine essence and the agastache rugosus essence and mixing uniformly, arranging the mixture into a colloid mill for milling ten minutes so as to obtain essence compound; taking the malto dextrin, the caramel pigment, the sunset yellow pigment, the tartrazine, and the sucrose octaacetate and adding water for dissolving, then adding the essence compound in the mixture and mixing uniformly, spraying and drying the mixture liquid so as to obtain spray drying powder; and sieving the spray drying powder by a sieve with 100 meshes, and mixing the spray drying powder with the non-decoction coronary heart particles uniformly, mixing the obtained drying powder is mixed, granulating by a drying method, packaging and then obtaining the placebo. The placebo for the coronary heart disease is more similar to the non-decoction coronary heart particles in smell, taste and color, is not easy to be taken as a placebo by a tester, so that blindness breaking of a double-blind experiment can be guaranteed to be difficult.

A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient.Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and / or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and / or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.

A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and / or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and / or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.

The invention discloses a method for refining water extract of a traditional Chinese medicine (TCM) composition. The TCM composition is composed of TCMs such as ginseng, radix ophiopogonis, fructus corni, salvia miltiorrhiza, fried spina date seeds, parasitic loranthus, red paeony root, ground beetle and rhizoma nardostachyos and can effectively treat premature ventricular contraction of coronary heart diseases. The method has the following beneficial effects: an inorganic ceramic membrane is adopted for filtration to refine the extract of the TCM composition; the active ingredients have high transfer rate; the extract can be industrially produced; the material liquid is simple to process; and the inorganic ceramic membrane is convenient to wash and can be regenerated.

The invention relates to bitter gourd and kudzuvine root yoghurt and a preparation method thereof. The preparation method comprises the following steps: mixing a milk product with bitter gourd juice, kudzuvine root liquid, a stabilizer and sucrose, and performing bacterial fermentation. The bitter gourd and kudzuvine root yoghurt contains various probiotics and active ingredients such as saponins and flavones, has the effects of clearing heat and toxic materials, dispelling the effects of alcohol, benefiting the stomach, protecting the liver and the like, and is capable of effectively reducing blood fat, blood pressure and blood sugar and assisting in treatment of coronary heart diseases and angina pectoris.

The invention relates to a lipid-lowering intestine-moistening vinegar drink and a preparation method thereof, belonging to the field of brewage. The lipid-lowering intestine-moistening vinegar drink is prepared from ginkgo fruit, rhodiola root, Dendrobium nobile Lindl., haw juice, blueberry juice, sea-buckthorn fruit juice, ginseng, wolfberry, Chinese yam juice, Chinese-date, Cordyceps militaris, stevioside, xylooligosaccharide, vitamin, selenium-rich tablet and millet vinegar. On the basis of a secret prescription handed down from ancestors and summary of clinical experience of years, the vinegar drink is developed through repeated experiments; and the vinegar drink exerts unique curative effect on intractable hyperlipidemia as well as on hypertension, hyperlipidemia, constipation, encephalatrophy, cerebral thrombus, coronary heart diseases, cerebral arteriosclerosis and sequela of apoplexy, and has the advantages of fast action, a short treatment course, a high cure rate and low cost.

The invention relates to traditional Chinese medicine extract for treating stagnation of blood stasis as well as a preparation and a preparation method thereof. The traditional Chinese medicine extract is prepared by extracting 20 material medicines including red flowers, roots of common peony, ligusticum wallichii and the like. The traditional Chinese medicine extract has a very high curative effect for heart and cerebral vusculer diseases including cerebral infarction, coronary heart diseases and the like which are caused by stagnation of blood stasis, a small side effect and does not apply virulent animal medicines; a solid preparation prepared from the traditional Chinese medicine extract and auxiliary materials is preferably a pill or a tablet which has good stability, formability and effectiveness.

The invention discloses a method for processing donkey meat. The method comprises the following steps: after washing the donkey meat, putting clean water; after adding yellow wine and aromatic vinegar for soaking, putting a stockpot on fire, pouring clean water and boiling, and then putting in cold water for cooling; pickling the donkey meat in salt, flour, starch, monosodium glutamate, black pepper, anise, fennel, onion powder, garlic powder, ginger powder, cinnamon, pericarpium citri reticulatae, clove, cool ginger, amomum tsao-ko, nutmeg, radix angelicae, rhizoma kaempferiae and water; after pickling, directly putting the donkey meat and juice in a pot for marinating; after marinating, retaining freshness at constant temperature; finally, carrying out cold cutting, sterilization and vacuum packaging. The method is simple in processing process, and the donkey meat is ready to enjoy when being opened, has high protein, low fat, high amino acid and low cholesterol, and has a good health care effect on arteriosclerosis, coronary heart diseases and hypertension.

The invention discloses a health-care green tea capable of reducing blood pressure and blood fat. The health-care green tea is prepared from the following raw materials in parts by weight: 20-40 parts of green tea, 5-10 parts of radix puerariae, 5-8 parts of gynostemma pentaphyllum, 10-15 parts of bitter gourds, 4-7 parts of ginkgo leaves, 3-6 parts of honeysuckles, 7-10 parts of mulberry leaves, 2-5 parts of glabrous greenbrier rhizomes, 2-6 parts of cortex fraxini, 4-10 parts of purslane and 3-7 parts of natural indigo. The health-care green tea capable of reducing blood pressure and blood fat, provided by the invention, is good in mouth feel, can expand cerebral artery vessels and coronary artery vessels and reduce the stickiness of blood so as to achieve the purpose of adjusting the blood fat after being drunk for a long term, is significant in effects, is extremely suitable for treating high blood fat, and has a good effect of preventing and treating coronary heart diseases, high blood pressure and diabetes.

The invention discloses a Chinese medicinal composition for preventing or treating coronary heart diseases. The composition can safely and effectively prevent or treat coronary heart diseases. The composition comprises red sage roots extract taking total phenolic acid of red sage roots as effective parts, radix pseudo-ginseng extract taking total saponin of radix pseudo-ginseng as effective parts, long pepper extract taking total alkaloid of long pepper as effective parts, as well as succinum extract taking total diterpene of succinum as effective parts, and utilizes the therapeutical effect of the compatibility of the components on coronary heart diseases to give play to multi-link multi-channel multi-target effect of promoting blood circulation to remove blood stasis, activating collaterals and relieving pain. The composition can be medically acceptable solid oral preparations, such as tablets, capsules (soft capsules or hard capsules), granules and other types of preparations. The composition is used for treating coronary heart diseases, heart failure, arrhythmia and the like, and has the advantages of use safety, effectiveness, stability, controllability and convenience.

The invention discloses an LDCT image super-resolution enhancement method and device based on a residual convolutional neural network. According to the method, firstly, a network structure of an improved hybrid cascade task convolutional neural network (taking U-Net as an example) is designed, and then according to the designed network structure, a large number of LDCT low-resolution images and truth-value high-resolution images are provided for network training. The network training process is formed by performing feature extraction, error calculation and error back propagation on an improved hybrid cascade task U-Net, and back propagation is performed on an error value. The specified learning rate is 0.0001, the optimizer is ADAM, the learning rate adopts a stage decreasing strategy, and the loss between the super-resolution CT image and the true-value high-resolution image is continuously reduced. The method can be suitable for screening, detecting and analyzing three diseases (pulmonary nodules, chronic obstructive pulmonary diseases and coronary heart diseases) and the spine through one-time chest LDCT scanning in the medical field, and extra high-precision CT scanning does not need to be conducted on a certain local part of the chest with the higher spatial resolution requirement.

The invention discloses a Docynia delavayi polyphenol extract which has polyphenol content of 91.24 to 91.34% (w / w). The invention also provides a preparation method for the extract. With extraction conditions provided in the invention, polyphenol substances can be maximally extracted from Docynia delavayi, and an extraction rate is as high as 18.54%. High-purity polyphenol and phlorizin can be obtained by further purifying a crude extract with the purifying method provided by the invention. Pharmacological experiments show that the Docynia delavayi polyphenol extract can substantially reduce the levels of cholesterol TC, triglyceride TG, high-density lipoprotein HDL-C and low-density lipoprotein LDL-C in the serum of mice; thus, the Docynia delavayi polyphenol extract can effectively prevent and treat diseases related to abnormal lipids metabolism, such as obesity resulting from abnormal blood fat content, hyperlipidemia, atherosclerosis and coronary heart diseases.

The invention discloses Chinese medicinal powder for treating an ischemic heart disease, which is prepared from six Chinese medicinal materials: American ginseng, root of red-rooted salvia, notoginseng root, dwarf lilyturf tuber, Chinese angelica and shizandra berry. In the Chinese medicinal powder has a formula of medicines, and is scientific and reasonable in compatibility; and the Chinese medicinal powder achieves the effects of nourishing heart, nourishing blood, promoting blood circulation and invigorating yang to consolidate constitution by nourishing heart and blood, invigorating yang to consolidate constitution and strengthening body resistance under the combined and synergistic action of the medicines, so the Chinese medicinal powder is particularly suitable for treating the ischemic heart disease and also has the obvious curative effect on other heart diseases, pulmonary heart diseases and emphysema. By the Chinese medicinal powder, the problem that the medicines for treating the ischemic heart disease have large side effect and the problem that coronary heart diseases and other heart and pulmonary diseases cannot be treated by one medicine but must be treated under the combined action of the medicines are solved; and various heart diseases caused by myocardial ischemia can be cured fundamentally to solve the problem that the ischemic heart disease is relapsed repeatedly after the treatment of the conventional medicine for treating the ischemic heart disease, and one medicine with multiple medicinal effects also relieves economic burdens for patients.

The invention relates to a pu-er tea ferment soft capsule which is capable of regulating yin-yang, sedating, and lowering blood pressure and is used for various vascular hypertensions and various complicating diseases of heart, brain and kidney caused by vascular hypertension. The medicament comprises pu-er tea extract, aweto, lumbricus, black-snakes, monascus purpureus, rhizoma dioscorea, wolfberry fruit, cassia seeds, tortoise shells, fleece-flower roots, roots of red rooted salvia, round cardamom, angelica dahurica, tangerine peels, spine date seeds, ginkgo biloba, safflower, hawthorn, and the like. The production method comprises the following steps: hydrolyzing pu-er tea to prepare pu-er tea extract by using the purification and zymohydrolysis method, mixing the sundried powders such as aweto, lumbricus, tortoise shells, fleece-flower roots, roots of red rooted salvia, and the like to make soft capsules. In the invention, effective components are largely reserved due to the adoption of the purification and zymohydrolysis method, the medical value of the soft capsule can be fully improved; the preparation can improve blood oxygen saturation, is suitable for the diseases such as vexation, chest distress, short breath, hypertension, hyperlipidemia, arteriosclerosis, arrhythmia, myocardial ischemia, angina pectoris, coronary heart diseases, strokes, and the like.

The invention discloses application of NADPH in preparation of drugs used for treating or preventing cardio-cerebrovascular diseases. Research results show that NADPH can protect vascular endothelial cells and maintain normal vascular permeability and is a candidate drug used for treating or preventing cardio-cerebrovascular diseases, especially thrombotic diseases, hypertension, coronary heart diseases, vascular sclerosis and vascular sclerosis caused by damage of vascular endothelial cells.

The present invention discloses soda sandwich biscuit capable of enhancing human body metabolic functions and a preparation method thereof. The soda sandwich biscuit comprises the following raw materials: wheat flour, palm oil, wafer sandwich, edible corn starch, white granulated sugar, shortening, cheese powder, edible salt, sodium hydrogen carbonate, yeast, edible essence and calcium hydrogen phosphate; wherein the cheese powder comprises the following raw materials: cheese, white granulated sugar, edible corn starch, capsanthin, silicon dioxide and edible essence; and wherein the wafer sandwich comprises the following raw materials: whole milk powder, sodium glutamate, citric acid, modified soybean phospholipids and turmeric. The produced biscuit is mellow in aroma, stable in color andluster, good in taste, and rich in linoleic acid and vitamin E, can effectively lower cholesterol, prevents hypertension and coronary heart diseases, can more effectively promote intestinal peristalsis, inhibits absorption of toxic substances, and enhances human body metabolic functions.

The invention provides an antiarrhythmic traditional Chinese medicine composition, which is characterized in that it is made of the following raw materials in parts by weight: 40-200 parts of ginseng, 100-500 parts of astragalus, 400-650 parts of salvia miltiorrhiza, 50-400 parts of red peony , 50-450 parts of Ophiopogon japonicus and 1.5-4.5 parts of borneol. The present invention also provides a preparation method for the above-mentioned traditional Chinese medicine composition tablet, which includes the following steps: extracting active ingredients from five kinds of medicinal materials: ginseng, astragalus, salvia miltiorrhiza, red peony root, and radix japonicus to obtain a clear ointment; mixing the above-mentioned clear ointment, and preparing Granules: crush borneol, add to the above granules together with auxiliary material glidants, mix uniformly, compress into tablets, and coat with film to obtain Chinese medicine composition tablets. The traditional Chinese medicine composition provided by the invention is mainly suitable for treating arrhythmia of coronary heart disease, has definite curative effect, has no toxic and side effects, and has good safety; it is usually made into tablets and is convenient to take; it does not contain sugar and is suitable for patients.