13 results about "Fluroxene" patented technology

The invention discloses a low-damping PVC-U electrical conduit and a processing technology thereof, and belongs to the technical field of conduit preparation. The low-damping PVC-U electrical conduit is prepared from the following components in parts by weight: 70 to 80 parts of PVC resin, 30 to 42 parts of light calcium carbonate, 8 to 15 parts of ethylene-vinyl acetate copolymer, 0.5 to 1 part of ethylene bis stearamide, 3 to 6 parts of epoxy compound and 4 to 7 parts of compound stabilizer, the preparation method comprises the following steps: preparing an epoxy compound from ethyl benzoylacetate, 2-(trimethylsilyl) phenyl trifluoromethane sulfonate, p-toluenesulfonyl azide, p-aminophenol, p-toluenesulfonyl chloride, iodobenzene diacetic acid and rhodium diacetate as raw materials, and preparing the compound stabilizer from 2-(2-aminoethoxy) ethanol, 4-fluorophenol and xylene alkane diisocyanate as raw materials. The PVC-U electrical conduit prepared from the substances has the advantages of low damping, excellent stability, excellent mechanical property and excellent aging resistance.

The invention discloses a preparation method of a tergorazan intermediate, which comprises the following steps: (1) 3, 5-difluorophenol and 3-chloro-1-propanol are dissolved in isopropanol, the molar ratio of the 3-chloro-1-propanol to the 3, 5-difluorophenol is (1-1.5): 1, alkali is added, and heating reflux reaction is performed; (2) 3-bromo-1-propanol is added into the reaction system in the step (1), the molar ratio of the 3-bromo-1-propanol to the 3, 5-difluorophenol is (0.1-0.15): 1, and heating reflux reaction is continued; and (3) after the reaction is finished, filtering and concentrating under reduced pressure to obtain the intermediate compound 3-(3, 5-difluorophenoxy)-1-propanol of the tergorazan. According to the method, dangerous reagents are not used, the industrial production cost can be reduced, the yield is high, and the product purity is high.

The invention is applicable to the technical field of drug synthesis, and provides a preparation method of a regorafenib intermediate, which comprises the following steps: under the protection of nitrogen, adding N-methyl-4-chloro-2-pyridinecarboxamide, 4-amino-3-fluorophenol, N-methyl pyrrolidone and tetrahydrofuran into a reaction device for mixing, dissolving and clarifying, and heating to 80-90 DEG C; the method comprises the following steps: dissolving potassium tert-butoxide by using N-methyl pyrrolidone to obtain a potassium tert-butoxide solution; and when the internal temperature of the reaction device reaches 80-90 DEG C, quickly adding a potassium tert-butoxide solution for full reaction, and cooling and crystallizing to obtain the regorafenib intermediate. According to the method disclosed by the invention, the contents of process impurities I and II are greatly reduced, the conversion rate and the yield are remarkably improved, the dosage of N-methyl pyrrolidone is reduced, the production cost is reduced, the obtained regorafenib intermediate is high in yield and purity, the product quality strictly meets the standard, and the method is suitable for industrial production. And a technical scheme with economical efficiency and reliability is provided for industrial production.

The invention provides a novel green and efficient method for defluorination hydroxylation of a carbon-fluorine bond of polyfluorinated aromatic hydrocarbon. According to the method, the selective carbon-fluorine bond activation and hydroxylation reaction of the polyfluorinated aromatic hydrocarbon is realized by taking sodium hydroxide which is low in price and easy to obtain as an accelerant under the mild condition without participation of transition metal. In addition, the method has the characteristics of mild conditions, good functional group tolerance, simple post-treatment, green steps, low pollution, high economic benefits and the like.

The application belongs to the technical field of polyurethane elastomers, and particularly relates to a fluorine-containing polyurethane elastomer for harsh environments and a preparation method thereof. The elastomer is prepared by adding a chain extender to a fluorine-containing polyurethane prepolymer prepared from a fluorine-containing polyether polyol or a mixture of the fluorine-containing polyether polyol and a non-fluorine-containing polyether polyol and diisocyanate, and then vulcanizing after curing. The preparation method of the fluorine-containing polyether polyol comprises the following steps: polymerizing fluorine-containing phenolic compounds and INOVOL C304 as a composite initiator with propylene oxide under the action of a DMC catalyst to obtain the fluorine-containing polyether polyol; and the fluorine-containing phenolic compounds are one of 3,4,5-trifluorophenol, pentafluorophenol or heptafluoro-2-naphthol. The fluorine-containing polyurethane elastomer has excellent high-temperature resistance, hydrolysis resistance and chemical resistance; and the preparation method is simple and easy to implement, and is suitable for large-scale production.

The present invention relates to a process for providing halogenated 3,4-difluorophenol and 3,4,5-trifluorophenol. Further it relates to a process for converting it to substituted azine compounds with herbicidal activity.

This invention relates to the field of coating technology and discloses a two-component carbon-based waterproof coating and its preparation method. The coating includes component A: by mass parts: 80-120 parts chitosan-modified polyurethane, 4-8 parts chitosan, 10-12 parts filler, 0-0.1 parts wetting agent, and 0-0.1 parts defoamer; component B: by mass parts: 10-15 parts hydrogen-containing silicone oil and 0.01-0.02 parts catalyst; the preparation steps of chitosan-modified polyurethane are as follows: polytetrahydrofuran ether diol and isophorone diisocyanate are added to ethyl acetate and stirred evenly, dibutyltin dilaurate is added dropwise, and the reaction is carried out at 75-77°C for 2-4 hours, chitosan composition is added, dibutyltin dilaurate is added again, and the reaction is continued at 75-77°C for 4-8 hours, fluorophenol is added, and the reaction is kept at this temperature for 0.5-2 hours. The solvent is removed to obtain chitosan-modified polyurethane.

The invention discloses a preparation method of 1-(3, 5-difluoro-2-hydroxybenzene) ethyl-1-ketone, which comprises the following steps: (1) taking a compound (III) 2, 4-difluorophenol as an initial raw material, and carrying out substitution reaction on the compound (III) 2, 4-difluorophenol and acetyl chloride to generate a compound (II) 2, 4-phenyl difluoroacetate; and (2) carrying out an intramolecular Friedel-Crafts reaction on the compound (II) 2, 4-phenyl difluoroacetate to prepare a compound (I), namely the 1-(3, 5-difluoro-2-hydroxybenzene) ethyl-1-ketone. Compared with a traditional method, the preparation method disclosed by the invention has the following advantages: firstly, reaction conditions are mild, and dangerous chemical reactions are not involved; 2, the operation is simple, complicated purification modes such as column chromatography are avoided, and kilogram-level preparation is facilitated; 3, the raw materials are cheap and easy to obtain, the cost is lower, the steps and atom economy are better, and efficient synthesis economics is met; and 4, the total yield is high, and the method has great economic value.

The invention discloses a method for continuously preparing p-fluorophenol, which comprises the following steps of: salifying p-fluoroaniline and dilute sulphuric acid in a first static mixer, diazotizing the salified solution and nitroso sulfuric acid in a second static mixer to form a diazonium salt solution, injecting the diazonium salt solution and an extracting solvent into a pressurized tower reactor for hydrolysis, according to the present invention, the reaction process is simple and efficient, the whole-process continuous production can be achieved, the production risk is low, the controllability is good, the three wastes are less, the pollution is less, the investment is low, the product p-fluorophenol is rapidly separated by using the thin film flash evaporation, and the method is suitable for industrial production. The thermal decomposition of the product under the condition of high temperature and long time is obviously reduced, the total yield of the prepared p-fluorophenol is 90% or above, and the purity is 99.5% or above.

The present invention relates to an improved process for preparing halophenols from haloaryl halides by copper-catalyzed hydroxylation reactions using suitable ligands. More specifically, the present invention relates to a method for preparing 3-chloro-2-fluorophenol from 3-chloro-2-fluoroiodobenzene, 1-bromo-3-chloro-2-fluorobenzene, or 1, 3-dichloro-2-fluorobenzene, by means of a copper catalyzed hydroxylation reaction using suitable ligands, to a process for preparing 3-chloro-2-fluorophenol from 3-chloro-2-fluoroiodobenzene, 1-bromo-3-chloro-2-fluorobenzene, or 1, 3-dichloro-2-fluorobenzene.

The present invention is entitled "A Continuous Flow Preparation Method for Tegoragen Intermediates", belonging to the field of chemical synthesis technology. The technical problem to be solved is that the existing preparation methods have safety risks, long reaction time and low yield. The key points of the technical solution are as follows: The continuous flow preparation method of the present invention is as follows: (1) 3,5-difluorophenol and 3-chloropropanol are dissolved in organic solvents to form solutions, and then reacted with organic amines in a microreactor. After the reaction is completed, the material is discharged and the organic layer 1 is separated; (2) 2,2,6,6-tetramethylpiperidine oxide is added to the organic layer 1, and then reacted with sodium hypochlorite solution and sodium chlorite solution in a microreactor for oxidation reaction. After the reaction is completed, the material is discharged and the organic layer 2 is separated; (3) The organic layer 2 is then reacted with concentrated sulfuric acid in a microreactor. After the reaction is completed, the material is washed with water and the organic layer 3 is separated. After concentration and recrystallization, the tegoragen intermediate 5,7-difluorobenzodihydropyran-4-one is obtained.

The utility model discloses a trifluorophenol sampling device, and belongs to the field of sampling devices.The trifluorophenol sampling device comprises a base, supporting legs are fixedly connected to the bottom of the base, a C-shaped plate is fixedly connected to the upper ends of the supporting legs, an air cylinder is fixedly connected to the upper end of the C-shaped plate, and a sampling barrel is fixedly connected to the output end of the air cylinder; a sampling box is fixedly connected to the upper end of the base, a connecting pipe is fixedly connected to the side face of the sampling box, the other end of the connecting pipe is fixedly connected with a sampling barrel, and an adjusting device is arranged in the base and comprises a rotating shaft. By arranging the adjusting device, through the rotating shaft and the connecting rod mechanism, the distance between the mounting plates can be adjusted according to different sampling environments. Due to the flexibility, the equipment can adapt to different sampling requirements, power steering and transmission of the motor A are effectively achieved, it is ensured that the movement direction of the rotating shaft can be adjusted according to actual requirements, and the operability of the equipment is enhanced.

The invention belongs to the technical field of polyurethane elastomers, and particularly relates to a fluorine-containing polyurethane elastomer for a severe environment and a preparation method of the fluorine-containing polyurethane elastomer. The elastomer is prepared by the following steps: preparing a fluorine-containing polyurethane prepolymer from fluorine-containing polyether polyol or a mixture of fluorine-containing polyether polyol and non-fluorine polyether polyol and diisocyanate, adding a chain extender into the fluorine-containing polyurethane prepolymer, curing, and vulcanizing. The preparation method of the fluorine-containing polyether polyol comprises the following steps: taking a fluorine-containing phenolic compound and INOVOL C304 as composite initiators, and polymerizing the composite initiators with epoxypropane under the action of a DMC catalyst to obtain the fluorine-containing polyether polyol, the fluorine-containing phenol compound is one of 3, 4, 5-trifluorophenol, pentafluorophenol or heptafluoro-2-naphthol, and the fluorine-containing phenol compound is one of fluorine-containing phenol, pentafluorophenol and heptafluoro-2-naphthol. The fluorine-containing polyurethane elastomer disclosed by the invention has excellent high temperature resistance, hydrolysis resistance and chemical resistance; the preparation method disclosed by the invention is simple and feasible, and is suitable for large-scale production.