16 results about "Metabolism proteins" patented technology

The invention relates to the technical field of medical health management, in particular to a chronic kidney disease and diabetes collaborative nutrition monitoring and early warning method and system.The method comprises the steps that multi-dimensional physiological indexes, nutrition intake and sleep data of a patient are obtained, and a dynamically-coupled metabolic state topological space is constructed; based on the space, constructing a dual-disease metabolism coupling matrix, analyzing stability characteristics of a metabolism state trajectory, identifying stable and unstable attractors, and calculating a multi-dimensional risk score; a sleep-metabolism synchronism risk prediction model is introduced, and a personalized early warning threshold value is dynamically adjusted; when the risk score exceeds a threshold value, early warning is triggered, and intervention suggestions are generated, the interactive influence of protein metabolism and glycometabolism is quantitatively described from the metabolic mechanism level, and the contradiction of chronic kidney disease and diabetic patients in nutrition management is solved; limitation of a static threshold is broken through, and dynamic risk assessment is realized; sleep factors are creatively integrated, and a new way for improving the metabolic state is provided.

The invention belongs to the technical field of biological medicines, and particularly relates to application of poecilobdella manillensis in preparation of a medicine for treating renal injury. The invention provides a new application of poecilobdella manillensis in preparation of a medicine for treating renal injury, serum biochemical index detection proves that the poecilobdella manillensis can effectively reduce serum creatinine and blood urea nitrogen levels, increase serum albumin and total protein content, remarkably improve glomerular filtration function and protein metabolism function, and improve renal function. And the improvement degree of the traditional Chinese medicine composition is superior to that of a traditional Chinese medicine contrast. Although the curative effect is slightly poorer than that of a chemical drug group, the safety advantage is remarkable. The poecilobdella manillensis can comprehensively regulate renal function metabolism indexes, relieve kidney injury and avoid common side effects of chemical drugs, provides a new choice for clinical treatment of kidney injury, and is especially suitable for chronic kidney disease patients needing long-term treatment.

The invention provides an ovarian cancer monitoring system based on iron metabolism related protein, comprising: an information monitoring module for monitoring iron metabolism protein index data and ovarian cancer core biomarker index data of a user; the abnormality determination module is used for comparing the iron metabolism protein index data and the ovarian cancer core biomarker index data with historical personal baselines of the current ovarian cancer development stage of the user, determining the variation amplitude, and triggering the ovarian cancer analysis module to perform analysis when the variation amplitude meets preset requirements; and the ovarian cancer analysis module is used for updating the ovarian cancer risk index grade based on the iron metabolism protein index data of the user and the ovarian cancer core biomarker data. According to the invention, the iron metabolism protein index is combined with the ovarian cancer core biomarker, and the biological characteristic of iron-dependent proliferation of the ovarian cancer cells is utilized, so that an index basis which is more suitable for a disease mechanism is provided for monitoring, and the possibility of early abnormality capture is improved.

The invention provides a milk flavor essence and a preparation method thereof. The method comprises the following steps: preparing an activated bacterium solution from German-type lactobacillus bulgaricus subspecies; anhydrous cream and whey powder are prepared into a fermentation substrate; adding the activated bacterial liquid into the fermentation substrate, and performing sealed fermentation to obtain a fermentation product; and carrying out first sterilization treatment on the fermentation product, carrying out centrifugal separation, and taking supernate as the milk-flavored essence. Whey powder is added when a fermentation substrate is prepared, the whey powder is rich in whey protein, lactose, vitamins and mineral substances, and glycometabolism, protein metabolism and lipid metabolism pathways are activated in the fermentation process, so that a fermentation product not only can be rich in target milk flavor substances, but also can synergistically contain various flavor compounds such as esters, alcohols and aldehydes, and the richness of the flavor substances is improved; the anhydrous cream and the whey powder are prepared into the fermentation substrate, so that a comprehensive and balanced growth environment is provided for the German-type lactobacillus bulgaricus subspecies, and the fermentation efficiency is improved.

The present invention relates to a method for producing health-functional milk, comprising the step of selecting healthy dairy cows suitable for raw milk production by analyzing their health status after performing a comprehensive health examination including blood tests on dairy cows, and milking the selected dairy cows while feeding them a feed for constitutional improvement according to the lactation period after calving; wherein the comprehensive health examination includes protein metabolism, energy metabolism, liver function, and mineral metabolism. Accordingly, compared to milk produced by conventional methods, it can exhibit effects such as a fresh taste, reduced off-flavors and fishy tastes, and immune activity.

The present application relates to the field of food or medicine, and particularly relates to a kind of food-medicinal Chinese medicine composition and Chinese medicine preparation, preparation method and application.The raw materials of the food-medicinal Chinese medicine composition of the present application include yam, fuling, radix puerariae, medlar, mulberry leaf, hawthorn, cassia, polygonatum and gardenia.The food-medicinal Chinese medicine composition of the present application takes "clearing heat and drying dampness, benefiting qi and nourishing yin, promoting blood circulation to remove meridian obstruction" as the basic principle, adjusts the function of viscera, improves sugar, lipid and protein metabolism, promotes the recovery of the body environment to normal, and fits the basic pathogenesis of the middle and late stage of type 2 diabetes, and has accurate treatment effect.

The invention provides a Chinese herbal medicine feed additive for preventing and treating diarrhea of livestock and poultry and a preparation method thereof, and relates to the field of feed additives, the Chinese herbal medicine feed additive is composed of dandelion, mahonia bealei, rhizoma alismatis, gordon euryale seed, gallnut, Chinese yam, perilla leaf, pinellia ternate, red garden burnet, galangal, indigo naturalis, shiny cinquefoil root and bidens pilosa. The Chinese herbal medicine feed additive disclosed by the invention has broad-spectrum bacteriostatic activity on common pathogenic bacteria of livestock and poultry, can be used for remarkably reducing the occurrence rate of diarrhea of weaned piglets, reducing the levels of TNF-alpha and IL-6 in serum and increasing the content of IgA and IgG, and has an anti-inflammatory immune regulation effect; meanwhile, the feed additive can improve the content of TP and ALB in serum of weaned piglets, reduce the content of BUN, reduce the activity of ALT and AST, regulate protein metabolism disorder and protect liver and kidney functions; besides, the additive can optimize the intestinal microecological balance of weaned piglets, effectively prevent and treat diarrhea, and provide a safe and efficient prevention and control strategy for the diarrhea problem of livestock and poultry in large-scale breeding.

The invention provides a feed for improving production performance of dairy cows and a preparation method of the feed. The feed comprises the following components in percentage by mass: 17.35% of alfalfa hay, 1.29-7.09% of beet grain meal, 19.84-23.44% of corn, 3.6-5.8% of whole cotton seeds, 0.82% of sodium bicarbonate, 29.57% of silage and the balance of 21.73% of concentrate supplement, and the silage comprises corn silage and tomato seedling silage. The preparation method of the feed is rapid and convenient, and the prepared feed can improve the milk fat correction milk yield, milk yield, feed conversion rate and milk protein rate of dairy cows, has positive influence on the protein metabolism capability, has no damage to the liver and kidney of an organism, and can improve anti-inflammatory factors and milk quality.

The application belongs to the technical field of microorganisms, discloses a Pseudomonas putida and application of the Pseudomonas putida as fish probiotics, and specifically discloses a Pseudomonas putida Pseudomonas putida CD, the strain has strong fat utilization capacity, can produce various beneficial extracellular metabolites, can promote fish lipid, carbohydrate and protein metabolism and weight gain, and can also improve the iron content and hemoglobin content in fish tissues. The Pseudomonas putida strain CD has good biological safety and has broad development prospects in the application as fish probiotics.

The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and / or vitamin B12 and, optionally, agents that impact heme protein metabolism.

The invention discloses a method for regulating female reproduction based on interference of insulin receptor genes. The expression quantity of the insulin receptor gene in the shrimp body can be efficiently reduced in an insulin receptor gene silencing mode, and the production process of ovary yolk of the shrimp body and the metabolism process of lipid and protein can be obviously influenced, so that the development and maturation of female gonads are regulated and controlled. The method for regulating female reproduction by the insulin receptor can obviously influence ovary development and maturation of the shrimp body, and has potential economic benefits. The invention provides a means for regulating (promoting or inhibiting) ovaries of full-eye crustaceans such as shrimps, crabs and the like, including regulating the functions of insulin receptor genes or the functions of transcription products or translation products of the insulin receptor genes.

The effects of the present invention include the effect of improving the ability to degrade soybean protein, and production activity of branched-chain amino acids such as valine, isoleucine, and leucine, as well as production activity of other amino acids including threonine, glycine, tyrosine, and lysine. Thus, effects of sarcopenia prevention and antioxidant activity can be obtained, and the effects of maintaining protein metabolism balance and ameliorating sarcopenia through muscle synthesis can also be obtained. In addition, compared to when each of the strains used in a strain mixture was used alone, the strain mixture exhibited improved autoaggregation, hydrophobicity, and adhesion to the intestines. Thus, when the strain mixture of the present invention is ingested, the corresponding strains can remain in the intestines for a long period of time.

The invention discloses a yak maintenance and growth net protein demand amount calculation method, and relates to the technical field of livestock breeding, and the method comprises the following steps: obtaining basic data of adult yaks through experiments, calculating the maintenance net protein demand amount, and building a growth net protein demand amount model; according to the method, the gradient feeding test, the nitrogen metabolism test and the comparative slaughtering test are integrated, protein metabolism and body composition first-hand data of the plateau adult yaks are directly obtained, an accurate mathematical model is established according to the data, the calculation result directly reflects the real physiological needs of the yaks, scientificity is remarkably enhanced, and based on the model, the real physiological needs of the yaks are directly reflected. By means of the method, the net protein requirement amount for maintaining the net protein and the net protein requirement amount for growth required by target weight gain of the yaks of any weight can be accurately calculated, the feed utilization efficiency can be greatly improved, the feeding cost can be reduced, nutrient emission can be reduced, and the growth performance of the yaks can be optimized.

The invention relates to the technical field of biological medicine, and provides a siRNA combination for inhibiting expression of LOC157273 and application of the siRNA combination, and the siRNA combination comprises one or more of 63 siRNA1, siRNA2, siRNA3, siRNA4, siRNA25, siRNA45, siRNA48 and the like. The siRNA composition provided by the invention can be used for targeted therapy of metabolic diseases related to the gene by inhibiting expression of the LOC157273 gene, and intervention on abnormal glucose metabolism, lipid metabolism and protein metabolism is realized.

The invention relates to the technical field of proteometabolism, and provides a proteometabolism method based on combination of complementary enzyme digestion, which comprises the following steps: firstly, selecting a key rate-limiting enzyme in a target metabolic pathway, modifying a coding sequence of the key rate-limiting enzyme, and inserting a specific protease recognition sequence; then, a pair of functional complementary protease fragments is constructed, expression strategies of the protease fragments in cells are designed respectively, one fragment achieves constant low-level expression, and the other fragment is expressed under the induction of a specific signal; when the two fragments coexist in cells, the two fragments can be combined to form an enzyme complex with cleavage activity, so that a target sequence on a rate-limiting enzyme is recognized and cleaved. And after the signal is removed, the enzyme complex is gradually decomposed, and the expression level of the target rate-limiting enzyme is recovered. In addition, according to the method, metabolic modeling and protein expression cost parameters are combined, and the expression proportion of protease to rate-limiting enzyme is synergistically optimized, so that the system stability and regulation efficiency are improved.

The invention discloses a CD73 gene and an application of a protein encoded by the CD73 gene in regulation and control of fat metabolism. A nucleotide sequence of the CD73 gene is shown as SEQ ID NO: 1. The expression quantity of the CD73 gene and the encoded protein thereof is in negative correlation with the fat content of the tissue. The CD73 gene and the encoding protein thereof influence the content of triglyceride and the number of lipid droplets and maintain the steady state of fat metabolism by regulating and controlling fat metabolism protein and fat metabolism signal channels. By increasing the expression quantity of the CD73 gene and the encoded protein thereof, fat degradation can be promoted, lipid droplets and triglyceride can be reduced, and fat deposition can be reduced. The CD73 gene and the expression quantity of the encoded protein thereof can be applied to regulation and control of pork fat deposition, improvement of carcass quality and improvement of production efficiency, and can also be used as a molecular target to develop related targeting technologies such as seed selection, identification and treatment. CD73 has a wide application prospect and a potential value in the aspect of fat metabolism regulation and control.