33 results about "Poly-L-lactic-polyglycolic acid" patented technology

The invention relates to a method for preparing polylactic acid / polyglycolic acid drug-loaded microspheres with controllable drug release. For a case of a low drug release efficiency, polylactic acid,polyglycolic acid, tea polyphenol, dichloromethane, gelatin polysorbate / 80 and deionized water are used as raw materials, a solution is prepared, the drug-loaded microspheres are prepared, suction filtering and vacuum drying are conducted to prepare the polylactic acid / polyglycolic acid drug-loaded microspheres with the controllable drug release, the degradation of drugs is effectively controlled, the phenomenon of sudden release of the drugs is relieved, the action and utilization of the drugs are effectively prolonged, and the method is advanced in process, accurate and detailed in data andhigh-purity in the prepared drugs and is an advanced preparation method for a drug slow release agent.

Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.

The invention discloses a broom-shaped hydroxycamptotecin-loaded sustained-release particle and a preparation method thereof. The preparation method comprises the following steps: dissolving hydroxycamptothecine (10-HCPT) and methoxyl-terminated polyethylene glycol- poly(dl-lactide-co-glycolide) (MePEG-PLGA) in an organic solvent, injecting into a disperse phase of a membrane emulsifier, and injecting an aqueous solution containing little polyvinyl acetate (PVA) into a continuous phase of the membrane emulsifier; leading the solution of the disperse phase to quickly enter the continuous phase at nitrogen pressure by adopting a porous glass membrane as a template to obtain suspension of the hydroxycamptotecin-loaded sustained release particle (MePEG-PLGA-HCPT); distilling the suspension in vacuum, removing the organic solvent, removing uncoated square medicinal crystal by ultrafiltration of a microporous filter membrane, and lyophilizing the suspension in vacuum in a lyophilizer for 24 hours to obtain the broom-shaped MePEG-PLGA-HCPT sustained-release particle. The method is reliable, and convenient to operate; the prepared irregular particle is high in drug-loading amount and encapsulation rate, is excellent in sustained release effect, and is particularly suitable for tumor local medication and tumor post-operation medication.

The invention relates to daidzein-entrapped polylactic polyglycolic acid (PLGA) nanoparticles and a preparation method thereof in the technical field of nanomedicines. The nanoparticles comprise the following components in percentage by mass: 0.1 to 45 percent of daidzein, 25 to 95 percent of polylactic polyglycolic acid and 1 to 65 percent of pharmaceutic adjuvant, wherein the molecular weight of the PLGA is between 8,000 and 15,000, the polylactic polyglycolic acid is long-chain macromolecules in which the ratio of the lactic acid to glycollic acid is 50:50, and the pharmaceutic adjuvant islecithin, cyclodextrin or polyvinyl alcohol (PVA). The daidzein-entrapped PLGA nanoparticles have the particle size of between 280 and 330 nanometers and concentrated particle size distribution, redissolved freeze-dried powder is not adhered, and the medicine loading rate of the PLGA nanoparticles is between 1 and 2 percent, and the encapsulating rate is between 80 and 84 percent.