5 results about "Poly-L-lactic-polyglycolic acid" patented technology

The invention relates to the technical field of oral medical materials, in particular to a tissue regeneration-guided oral repair membrane and a preparation method thereof. Comprising an outer layer and an inner layer, wherein the outer layer is a porous scaffold layer formed by a degradable polymer A, and the polymer A is selected from at least one of polylactic acid, polyglycolic acid, polycaprolactone or a copolymer thereof; the inner layer is loaded with a biocompatible hydrogel layer of a bioactive factor, and the bioactive factor is selected from bone morphogenetic protein, platelet-derived growth factor, vascular endothelial growth factor or a combination thereof. Comprising the following steps: preparing an outer layer solution; forming an outer-layer stent; preparing an inner layer precursor solution; gradient compounding and interface construction; performing crosslinking and curing; and post-processing. The invention provides a novel repairing film with intelligent degradation adaptability and precise biological factor controlled release capability.

The invention discloses a collagen composite artificial bone which is characterized in that raw materials comprise type I collagen and hydroxyapatite, and further comprise one or more of polylactic acid, polyglycolic acid, a polylactic acid-glycolic acid copolymer, polycaprolactone, poly (trimethylene carbonate), polymethyl methacrylate, hyaluronic acid and alginic acid. According to the collagen composite artificial bone, one or more specific high polymer materials are added in the preparation process of the artificial bone, so that the collagen composite artificial bone has excellent mechanical properties and stability, and the preparation method is simple, easy in expanded production, high in yield and low in cost. The artificial bone is suitable for various application fields such as various bone fractures with bone defects, nonunion or deformity healing, orthopedic bone grafting, other bone defect repair without bone grafting taboo in the orthopedics department and the like.

This invention relates to a strength-modified block copolymer based on polylactic acid (PLA) / polyglycolic acid (PEG), its preparation method, and its application, belonging to the field of block copolymer technology. It solves the technical problem in the prior art where PLA or PEG has poor compatibility with PB / AT, making it difficult for both to fully utilize their respective advantages. The preparation method of this invention involves first uniformly mixing phthalic acid, adipic acid, an aliphatic diol, a polyol with ≥3 hydroxyl groups, and an organometallic ester, then heating and reacting the mixture under reduced pressure to remove water and excess polyol, yielding an alcohol-modified poly(terephthalic acid-adipic acid-diol ester). Then, molten dehydrated lactone monomer, a catalyst, and solvent oil are added, and the mixture is heated and reacted to obtain the strength-modified block copolymer based on PLA / PEG. This block copolymer exhibits good toughness, ductility, elongation at break, heat resistance, and excellent impact performance, and can be used as a temporary plugging agent.

The invention discloses a long-acting antibacterial deodorant fabric as well as a preparation method and application thereof. The fabric comprises a fabric base material, a sustained and controlled release material and a functional material, the sustained and controlled release material and the functional material are adsorbed on the cloth base material; the controlled release material is selected from at least one of cellulose, polyolefin, acrylic acid, ethylene-vinyl acetate copolymer, polylactic acid, polyglycolic acid, polylactic acid-polyglycolic acid copolymer, polycarbonate, epoxy resin, polyamide, acetal polymer, polyester, polyurethane, polyimide and polystyrene derivative; the functional material is selected from at least one of tea polyphenol, lactic acid, a material capable of forming negative ions, soluble silver salt capable of forming Ag < + >, zinc oxide or inactivated lactobacillus and cyclodextrin. The fabric provided by the invention not only can keep excellent comfort of the fabric, but also prevents rapid failure caused by complete exposure of effective components or dissolution in contact with liquid, and realizes long-acting care of bacteriostasis and deodorization of hygienic products.

A method of repairing a bone fracture in a patient specifically configured for repairing critical-sized segmental bone fractures by utilizing patient-specific three-dimensional printed implants. The method includes imaging the bone fracture in need of repair; generating a fracture model of the bone fracture based on the imaging; forming a model of a bone repair implant based on the fracture model; manufacturing the bone repair implant using an additive manufacturing method based on the model; and surgically implanting the bone repair implant adjacent to the bone fracture in the patient. The bone repair implant includes a bone scaffold, a support plate, and a screw. The bone repair implant is constructed of a biodegradable material such as polylactic acid, polyglycolic acid, or poly lactic acid glycolic acid.