The invention relates to anti-oxidative fruit and vegetable powder and a preparation method thereof. The anti-oxidative fruit and vegetable powder disclosed by the invention is characterized by being prepared from the following raw materials in parts by weight: 2-3 parts of olive oil, 0.8-1 part of dried skim milk, 0.3-0.5 part of sanchi powder, 0.1-0.3 part of ginseng powder, 10-12 parts of bean dregs, 15-17 parts of grapes, 20-22 parts of cucumber, 18-20 parts of carrot, 20-25 parts of ponkan, 8-10 parts of walnut kernel, 1-2 parts of the root of kudzu vine, 1.5-1.8 parts of zornia gibbosa, 2-2.5 parts of eclipta alba, 2-3 parts of ginger, 1-2 parts of honeysuckle flower, 3-4 parts of fructus corni, 2.5-3 parts of medlar, 2-3 parts of Chinese angelica and 3-5 parts of seasoning liquid. The anti-oxidative fruit and vegetable powder disclosed by the invention is delicate in taste, fragrant in smell and unique in flavour and is capable of replenishing multivitamin and mineral substances for a human body; the anti-oxidative fruit and vegetable powder disclosed by the invention has the effects of resisting oxidization, promoting blood circulation, improving the functions of the digestive system, preventing cancer, resisting aging, preventing cardiovascular and cerebrovascular diseases, reducing blood pressure, astringing lung, nourishing kidney, clearing heat, removing toxicity, tonifying liver, improving eyesight, enriching blood and invigorating the circulation of blood.