The invention discloses a manufacturing method of an open caisson. The method comprises construction preparation work, foundation pit excavation and sand cushion layer and plain concrete cushion layermanufacturing, foundation pit excavation and sand cushion layer and plain concrete cushion layer manufacturing, open caisson first, second and third section manufacturing, open caisson first sinking,open caisson fourth and fifth section manufacturing, and open caisson second sinking. The open caisson adopts a non-drainage sinking process, the soil taking mode is air mud suction diver matching, and the sinking aiding mode is sinking by a pressing sinking method and sinking aiding by thixotropic mud resistance reduction; and the method further comprises underwater plain concrete bottom sealingof the open caisson, manufacturing of an open caisson bottom plate, and pipeline buttress, blowoff chamber and finishing construction. A five-section manufacturing method and a secondary sinking construction method are adopted; the pouring compactness is convenient to control, the pouring operation difficulty is low, the technical requirement threshold is low, the construction efficiency is high,the quality is easy to control, the construction safety factor is high, and the engineering cost is effectively reduced.