30results about How to "Strong slow release" patented technology

The invention relates to a method for preparing monodisperse mesoporous bioactive glass microspheres through a template method, belonging to the field of biomedical materials. A silicon source, a phosphorus source, a calcium source, an iron source, an alkali metal or alkaline-earth metal source is adopted as a raw material, a triblock copolymer or alkyl quaternary ammonium salt type cation is taken as a surfactant, and an in-situ sol-gel method is performed in a three-dimensional ordered macroporous polymer or a carbon template to synthesize the ordered mesoporous bioactive glass microspheres. The bioactive glass microspheres prepared according to the invention have the characteristics of good biocompatibility, biodegradability, ordered mesoporous structure, higher specific surface area, magnetism, monodispersibility of particles, environmental stability and the like; and in comparison with various medicament delivery carrier materials which are extensively researched currently, the bioactive glass microspheres have more comprehensive advantages and further have broad application prospects as novel medicament controlled release carrier materials.

The invention provides a chitosan-sericin composite biological scaffold as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving chitosan by taking an acetic acid solution as a solvent to obtain a chitosan solution; preparing a sericin aqueous solution from the cocoon of bombyx mori of the fibroin-deleted mutant variety; uniformly mixing the chitosan solution and the sericin aqueous solution and pouring into a mould; adding a crosslinking agent for moulding to obtain a chitosan-sericin composite hydrogel; and freeze-drying the chitosan-sericin hydrogel to obtain the chitosan-sericin composite biological scaffold. The invention also provides a composite biological scaffold carrying a nerve growth factor NGF for peripheral nerve entrapment treatment. The composite biological scaffold provided by the invention has good biocompatibility and relatively high porosity and degradability, and the degradation product also has a neurotropic effect; the composite scaffold also has antibacterial and anti-adhesion functions and the like; and compared with the traditional way of relieving sciatic nerve compression simply by operation, the composite biological scaffold provided by the invention can effectively promote the repairing of peripheral nerve entrapment injury.

The invention relates to the field of compound fertilizers, and particularly relates to a slow-release compound fertilizer containing natural worm-expelling components. The fertilizer is prepared from the following raw materials in parts by weight: 10-15 parts of kieselguhr of 1250-2000 meshes, 10-12 parts of potassium sorbate, 16-19 parts of ammonium dihydrogen phosphate, 4-5 parts of magnesium chloride, 10-12 parts of sodium pyrophosphate, 22-23 parts of well-rotted farmyard manure, 6-8 parts of dried tempeh fine powder, 4-6 parts of formosan lattuce herb leaf and stem, 5-6 parts of Tephrosia purpurea stem and leaf, 4-5 parts of burdock dreg powder, 1-3 parts of starch aluminum octenylsuccinate, 1-2 parts of potassium persulfate, 10-12 parts of acrylamide, 1-2 parts of negative ion powder, 2-4 parts of medical stone powder, 6-8 parts of polymeric ferric silicate sulfate and 4-5 parts of assistant. According to the invention, the compound fertilizer formula has wide raw material sources and multiple nutrients; slurry of the formosan lattuce herb leaf and stem and the Tephrosia purpurea stem and leaf contains natural worm-expelling components, so that worms and ants can be prevented from nibbling the fertilizer; and by technically using the kieselguhr and the slow-release coating agent containing the negative ion powder, the nutrients are doubly coated, so that the nutrients are less prone to loss, and the fertilizer efficiency can last longer. In practical application, the compound fertilizer can obviously improve the yield and quality of crops and increase economic benefits.

The invention relates to a preparation method of a chitosan multilayer coated wheat slow-release fertilizer. The preparation method comprises the following steps: uniformly mixing a fertilizer and auxiliary materials, adding into an acetic acid solution of chitosan, stirring until complete dissolution, and adding into a glutaraldehyde mixed solution of sodium alginate in a dropwise manner to formparticles with an inner coating layer; humidifying the particles with the inner coating layer, adding a chitosan outer coating material, uniformly coating the outer layer of the particles with the inner coating layer with the chitosan outer coating material to obtain particles with the outer coating layer, and finally drying, polishing and sieving to obtain the multilayer coated slow-release fertilizer. The multilayer coated slow release fertilizer prepared by the invention has slow/controlled release function, stably provides nutrition elements in a certain period of crop growth, completely provides fertilizer efficiency, reduces fertilizer loss, reduces the fertilization cost in crop planting, slows down soil degradation, and improves the quality and the yield of crops; and more importantly chitosan has good self-degradation function, does not cause any pollution to soil, and conforms to the concept of sustainable development.

The invention relates to the field of composite fertilizers, and concretely relates to a long-acting sustained-release composite fertilizer rich in organic materials. The fertilizer is prepared from the following raw materials in parts by weight: 10-15 parts of 1250-2000 mesh diatomite, 12-15 parts of ammonium humate, 8-10 parts of triple superphosphate, 5-6 parts of pumace, 6-8 parts of bean dregs, 4-5 parts of grass meal, 5-7 parts of lees vinegar, 1-2 parts of white sugar, 0.5-1 part of xylose, 18-20 parts of urea, 5-6 parts of borax, 8-10 parts of sodium carboxymethylcellulose, 6-8 parts of redispersible latex powder, 2-3 parts of ammonium ferric citrate, 8-10 parts of ammonium dihydrogen phosphate, 0.1-0.2 part of calcium stearate and 4-5 parts of an auxiliary agent. The raw materials of the composite fertilizer are rich in multiple organic materials, so that the soil activity is effectively improved, and the adverse influence of long-term fertilization on soil is improved; dual cladding on nutrient is formed by utilizing diatomite and a sustained-release coating agent in the production technology, so that nutrient is not easy to loss, the utilization rate is greatly improved; and release of nutrient is long-acting and efficient, and sufficient nutrient and balanced soil environment help to improve both crop output and quality, and the plantation benefit is increased.

The invention discloses a process for preparing chitosan-based self-assembled nano microcapsule and the pharmaceutical release and regulation method, wherein the nano pharmaceutical microcapsule is prepared through using N,N-dialkylated chitosan as the capsule material, employing modified retrograde evaporation method according to the principle of the self-assembly technique, i.e. carrying out a second supersonic operation before centrifugal separation. The obtained microcapsule has a dimension distribution between 100-250nm.

The invention discloses a freeze-dried nanometer powder injection of ursolic acid and a preparing method thereof. It major composes of active material of ursolic acid, complex vehicle of nanometer powder, excipient of freeze-drying. Compared to other popular preparations, its advantages are high target application of liver, concentrate on the affects, increase curative effect, decrease side effect, high dispersity and stability. It is prepared through dissolving ursolic acid as active raw material in medical organic solvent, adding complex vehicle of bean lecithin and stearic acid, stirring while heating until reaction completed, adding distilled water, adding excipient, stirring while heating until reaction completed, filtering with microporous membrane and freeze-drying the filtrate. Its average particle size is 209.5 mm, drug loading is 25.2%. it is for inhibiting and treating liver cancer, decreasing expression of p53, bcl-2 and topo-II.

The invention discloses a production method of a medical flexible gradual-change vessel catheter and belongs to the technical field of medical equipment production. The production method includes: using nylon block copolymer, hydroxyethyl methylacrylate-methyl methacrylate and collagen as the raw materials; using a LiBr or LiCl aqueous solution to extract the crushed and sterilized collagen; centrifuging; performing dialysis in ultrapure water to obtain dialysate; centrifuging the obtained dialysate to remove precipitates, and concentrating to obtain a mixed collagen aqueous solution; adding acovalent cross-linking agent, sufficiently and evenly mixing, and injecting into a sterile die to obtain a semi-finished flexible gradual-change vessel catheter; placing into a sterile plate, freezing, performing overnight freeze drying in a freeze vacuum drying machine under zero degree, and taking out the catheter obtained after the freeze drying from the die. The flexible gradual-change vesselcatheter produced by the method is good in bioactivity and biocompatibility, capable of achieving in-vivo natural degradation and capable of promoting the regeneration of long-distance injured peripheral nerves.

The invention discloses a slow-release chlorine dioxide disinfection card taking zeolite as a carrier, and mainly relates to the field of chlorine dioxide disinfection. The invention relates to a chlorine dioxide sustained-release agent and a preparation method thereof, and aims to overcome the defects of unstable chlorine dioxide gas, short product preservation time and the like in the prior art. According to the invention, a natural zeolite material is used as a carrier and is compounded with sodium chlorite and a combined catalyst, and moisture and carbon dioxide in air are used for participating in a reaction to generate slow-release chlorine dioxide, so that the release rate of chlorine dioxide gas is artificially controllable, and bacteria and viruses are killed. The disinfection card has an ultra-long slow-release capability of more than 30 days, and plays an effective role in the aspects of protecting susceptible people from virus invasion, purifying harmful components in air and the like.

The invention discloses an efficient broad-spectrum safe environment-friendly disinfectant capable of fumigation. The novel veterinary disinfectant disclosed by the invention is convenient and safe to use, has curative effect, has broad-spectrum anti-pathogen microbial activity, and does not pollute an environment. The disinfectant is mainly characterized in that the disinfectant can be applied to fumigation disinfection and comprises the following ingredients in percentage by weight: 65-75% of sodium dichloroisocyanurate, 4-6% of sodium carboxymethyl cellulose, 3-6% of sodium carbonate, 3-8% of anhydro sugar, and 5-25% of anhydrous sodium sulphate. The disinfectant has extremely strong killing capacity on pathogenic bacteria, spores, fungi, viruses and the like and can be applied to effective prevention and control of the occurrence and spread of infectious diseases of livestock, poultry and the like.

The invention discloses an acid-resistant glycolipid modified liposome and an application thereof. The glycolipid modified liposome is prepared from soybean lecithin, cholesterol and glycolipid according to the mass ratio of (1-5): 1: (1-5), has acid resistance, can tolerate the pH of 3.0-7.0, is good in dispersity and has the particle size of 70-90 nm. The lipid-modified liposome can directly remove a helicobacter pylori biological membrane. The invention also verifies that by using the glycolipid modified lipidosome to wrap antibiotics, effective and continuous slow release of drugs in a gastric acid environment can be realized, and the glycolipid modified lipidosome has the functions of gastric retention, mucous barrier penetration and helicobacter pylori biological membrane, so that the bioavailability of amoxicillin is remarkably improved. Helicobacter pylori infection can be eradicated, and treatment of helicobacter pylori related gastritis and gastric ulcer is promoted.