The invention provides a pharmaceutical composition which comprises 100-140 parts of peach kernel, 10-50 parts of rhubarb, 10-40 parts of mirabilite, 10-50 parts of cassia twig, 10-50 parts of honey-fried licorice root, 10-50 parts of safflower, 40-80 parts of hemlock parsley, 30-70 parts of red paeonia, 10-50 parts of radix cyathulae, 30-70 parts of angelica, 10-50 parts of radix rehmanniae, 60-100 parts of radix bupleuri, 10-50 parts of fructus aurantii, 10-50 parts of pangolin, 40-80 parts of Trichosanthes kirilowii Maxim root, 40-80 parts of hirudo, 10-50 parts of Tabanus, 5-35 parts of grub, 10-50 parts of patent drier, 10-50 parts of bitter almond, 40-80 parts of radix scutellariae, 10-50 parts of white peony root, 10-50 parts of pollen typhae, 30-70 parts of cortex moutan, 100-140 parts of ginger, 30-70 parts of radix ophiopogonis and 40-80 parts of Rhizoma Pinellinae Praeparata. The invention also provides a pharmaceutical brick using the pharmaceutical composition and a preparation method thereof.