The invention discloses an environmentally-friendly acid-and alkali-resistant wire. The environmentally-friendly acid-and alkali-resistant wire comprises seven outer protective layers and one kind of conductors; the seven outer protective layers include a galvanized annealed copper strip shielding layer, a nitrile insulation layer, a silver plated copper strip armor layer, a nickel strip shielding layer, an aluminum strip shielding layer, a chlorosulfonated ethylene-propylene polymer sheath layer and a rubber insulation layer which are distributed from inside to outside sequentially; the conductors are silver-plated annealed nickel conductors; and 24 silver-plated annealed nickel conductors are adopted. The raw materials in parts by weight of the rubber insulation layer include chlorinated polyethylene rubber, flame retardant, ethylene-vinyl acetate copolymer elastomer, barium sulfate, microcrystalline wax, carbon black, DOS, high-activity magnesium oxide, antimony oxide, DCP, TAIC, coupling agent and antioxidant. The environmentally-friendly acid-and alkali-resistant wire of the invention has the advantages of high acid and alkali resistance, environmental friendliness, inflame retardant performance, high temperature resistance and low temperature resistance, and can satisfy the needs of special cables such as acid and alkali resistant cables. According to the environmentally-friendly acid-and alkali-resistant wire of the invention, magnesium hydroxide or aluminum hydroxide is adopted to make the fire retardant, and therefore, requirements of a material system for flame retardant performance, low smoke zero and halogen-free performance can be satisfied.