The invention provides a neutral plug removal treating agent and a preparation method thereof. The neutral plug removal treating agent comprises the following components in percent by mass: 5 to 12 percent of an antiscaling agent, 0.5 to 1 percent of a synergist, 0.5 to 2 percent of a dispersing agent, 0.5 to 2 percent of a regulator, 5 to 10 percent of a cosolvent, and the balance of water. The neutral plug removal treating agent has the advantages that acidic materials are not added or produced during the whole process, wax, colloid and asphaltene covering the surface of sediments can be removed under a neutral low-temperature condition, and the neutral plug removal treating agent is neutral, non irritant, low-corrosion, low in transportation risk, and mild in plug removal reaction, effectively removes indissolvable inorganic scales, such as sulfate and carbonate, and achieves the purposes of elimination of transportation operation risk, reducing of tubular column corrosion rate, protection of a reservoir framework structure and improvement of the success rate of measures.