7results about How to "Short experiment time" patented technology

The invention relates to a high-resolution D-glucose structure analysis method based on a nuclear magnetic resonance spectrum, which comprises the following steps: placing a 2-5% D-glucose deuterium aqueous solution in a magnetic resonance spectrometer, and applying a 90-degree hard pulse to obtain a 1H spectrum; chemical shift information and 90-degree pulse time width of the proton pair are determined through a 1H spectrum, multi-frequency-point pulse selective filtering is executed, and a signal in a chemical shift area of the proton pair is obtained; separation and phase correction of multi-quantum signals are carried out through a multi-quantum filtering module and a CLIP-COSY module, and two one-dimensional nuclear magnetic resonance phase-sensitive correlation spectrums are obtained; and analyzing the phase-coded signal through Hardman coding to reveal the molecular structure of D-glucose. Through selective filtering and phase encoding, the invention provides an efficient and lossless nuclear magnetic resonance detection method for analyzing a D-glucose molecular structure.

The invention provides a method and system for predicting the water content of a crosslinked polyethylene material, electronic equipment and a medium, and belongs to the field of materials and electrical engineering. The method comprises the following steps: preparing test samples and reference samples with different water contents; acquiring a time-domain spectrum of the test sample at the current moment by utilizing a terahertz time-domain spectroscopy system, and converting the time-domain spectrum into a frequency-domain spectrum by utilizing Fourier transform; taking a signal corresponding to the reference sample as a reference signal, calculating an absorption coefficient of the test sample at the current moment, obtaining a corresponding absorption spectrum, and determining the water content at the current moment according to a peak value of a characteristic peak in the absorption spectrum; and inputting the data into a prediction model pre-constructed based on a contraction-expansion algorithm to obtain the water content of the crosslinked polyethylene material in the future period. By providing a prediction model suitable for crosslinked polyethylene, the long-time water absorption can be obtained by using shorter experiment time on the premise of ensuring the precision, and the development of technologies such as electrical equipment detection and the like can be further improved.

The invention relates to a method for determining silicon dioxide in quartz glass based on a high-temperature melting reaction-inductively coupled plasma atomic emission spectrometer. The method comprises the following steps: crushing and grinding a sample into powder; adding a strong alkali flux into the obtained powdery sample, and uniformly mixing to obtain a mixture; melting the mixture at high temperature; leaching reactants with hot water and fixing the volume; drawing a silicon element concentration-spectral line emission intensity standard curve; testing the content of silicon in the sample solution; and calculating the content of silicon dioxide according to the measured content of silicon. The method comprises the following steps: adding a strong alkali solvent into a powdery sample obtained by grinding the sample, carrying out a high-temperature melting reaction, heating water to dissolve a reactant, and determining the content of silicon in the solution by adopting an inductively coupled plasma atomic emission spectrometer, so as to calculate the content of silicon dioxide in the quartz glass sample.

The invention discloses an early warning evaluation method based on canceration caused by pulmonary nodule immune microenvironment imbalance, which comprises the following steps: S1, acquiring autoantibody detection data of normal, pulmonary nodule and lung cancer people from a database, and establishing a pulmonary nodule canceration data set Panne l containing 159 autoantibodies as risk early warning factors of pulmonary nodule canceration; s2, preparing a lung cancer risk factor Panne l protein chip according to the Panne l data, wherein the lung cancer risk factor Panne l protein chip comprises antigen proteins of 159 lung cancer related autoantibodies; s3, using a Panne l protein chip to detect the serum of the crowd; and S4, according to the detection data, establishing a risk early warning model of pulmonary nodule canceration for the analysis and early warning of the lung cancer occurrence risk of the crowd (mainly aiming at the pulmonary nodule crowd). According to the method, the cancer related autoantibodies are systematically detected through a protein chip method for people with high detection rate of pulmonary nodules in China, and the method is used for early warning of the occurrence risk of pulmonary nodule immune abnormality canceration of people.

The invention discloses a coal bed gas horizontal well drilling fluid plugging performance evaluation method, and relates to the technical field of oil and gas exploitation, coal dust and coal gangue returned by a coal bed gas horizontal well are taken, dried and crushed, a cementing agent is added, a glue-containing mixture is prepared, and curing and cutting are performed to obtain a coal rock plate or a coal rock plate with microcracks; a coal rock plate is used as a filtration medium of the plugging instrument, and the measured plugging filtration loss and the plugging filtration loss reduction rate are used as evaluation indexes for evaluating the coal rock plugging anti-collapse performance of the drilling fluid; a coal rock plate with micro-cracks is used as a filtration medium of the plugging instrument, and the measured plugging filtration loss and the plugging filtration loss reduction rate are used as evaluation indexes for evaluating the plugging anti-collapse performance of the drilling fluid on coal rock with micro-crack development, so that the anti-collapse performance of horizontal well water-based drilling fluid such as coal bed gas and the like can be reflected more reliably, quickly and accurately; the method is used for guiding safe and rapid construction of horizontal wells easy to collapse, such as deep coal bed gas and carbonaceous mudstone.

The present application belongs to the technical field of analytical chemistry, and particularly relates to a screening method for FcRn small molecule antagonists based on phase transition combined with FRET. In the present application, a fluorescent donor dye required in a FRET process is labeled on IgG, and a fluorescent acceptor dye is labeled on a phase transition material P4VP-SSO3Na-4VP; the phase transition material can reversibly change the phase when the environmental pH changes; when the material changes from a homogeneous system to a heterogeneous system, free IgG in the solution is embedded in the system, the distance between the fluorescent donor and the acceptor in the FRET process is shortened, and the fluorescent signal of the acceptor in the FRET system is detected; and further detection is made on whether the compound has antagonistic effect on FcRn, so as to screen FcRn small molecule antagonists. The present application overcomes the deficiency that some small molecule compounds have no suitable sites for dye labeling; has repeatability, low experimental cost, and can realize high-throughput and rapid screening of FcRn small molecule antagonists.

The invention provides a slurry creep multi-scale calculation method. The method comprises the following steps: S1, acquiring volume fractions of calcium hydroxide, pores and unhydrated particles in a sample to be detected; s2, the ratio of the LD C-S-H to the HD C-S-H is calculated through a Tennis-Jennings method, the mass fraction of the LD C-S-H and the mass fraction of the HD C-S-H are calculated, and then the mass fraction of the LD C-S-H and the mass fraction of the HD C-S-H are converted into the volume fraction of the LD C-S-H and the volume fraction of the HD C-S-H according to the mass fraction of the LD C-S-H and the mass fraction of the HD C-S-H; s3, the contact creep modulus of the LD C-S-H, the contact creep modulus of the HD C-S-H, the contact creep modulus of the calcium hydroxide and the unhydrated particles are obtained through a nanoindentation test, and then the contact creep modulus of C-S-H is calculated through the contact creep modulus of the LD C-S-H, the contact creep modulus of the HD C-S-H, the contact creep modulus of the calcium hydroxide and the unhydrated particles; and S4, calculating the creep modulus of the slurry through the contact creep modulus of the C-S-H. According to the method, the cost for testing the creep performance of the slurry is effectively reduced by establishing the database, overlong-time maintenance and a large number of nanoindentation experiments required by creep of the slurry are avoided, calculation is easy and convenient, and precision is high.