The invention discloses a compound multiple-effect sewage treatment flocculant and a preparation method thereof. The compound multiple-effect sewage treatment flocculant comprises the following raw materials in parts by weight: 80-90 parts of lignin, 25-30 parts of normal hexane, 25-30 parts of cyclohexane, 50-70 parts of propionic aldehyde, 100-120 parts of absolute ethyl alcohol, 30-50 parts of acrylamide, 20-30 parts of triethylenetetramine, 30-32 parts of sodium formaldehyde bisulfite, 4-6 parts of glycerol monostearate, 400-420 parts of isopropanol, 8-12 parts of methacryloyloxyethyl trimethyl ammonium chloride, 8-12 parts of acrylamido propyl trimethyl ammonium chloride, 10-14 parts of polymeric aluminum ferric sulfate, 8-12 parts of polymeric phosphate ferric chloride, 2-6 parts of poly aluminum chloride, 18-22 parts of sodium polyacrylate, 1-3 parts of sodium bisulfite, 2-4 parts of sodium hypophosphite, 10-12 parts of active carbon, 10-12 parts of raw gypsum and 280-320 parts of water.