The invention discloses a preparation technology for wine with arctium lappa and dunaliella salina, and belongs to the field of health-care wine. The traditional seaweed wine is mainly prepared by a method of directly soaking seaweed into food grain wine or edible wine, not only the color is turbid, the mouth feel is poor, the technology is crude, the cost is higher, the nutrient components are monotonous, but also the extraction rates of the nutrient components, such as carotene, glycerine, EPA, DHA, chlorophyll a, gamma-linolenic acids, macrolide, terpenoid, xanthophyll and sterol, in the seaweed are low. The preparation technology disclosed by the invention comprises the following steps: using food grain alcohol and distilled water for extracting dunaliella salina, sufficiently extracting the chlorophyll a, beta-carotene, phycocyanin, micro algae polysaccharide and CGF active factors in the dunaliella salina, and remaining the components of inulin, vitamins, protein and the like in the arctium lappa. The wine has the advantages that the product color is clear, and the taste of the wine is mellow, sweet, refreshing, fragrant and tangy; the wine can promote blood circulation for removing blood stasis, replenish essence for consolidating body resistance, can nourish the heart, sooth the nerves, dispel wind, eliminate dampness, maintain beauty and prolong the life; the operation is simple and convenient, the technological process is short, the raw materials are abundant, the benefits are high, and the market prospect is broad.