The invention discloses a polyvinyl chloride cleaning closed loop preparation system and method. The polyvinyl chloride cleaning closed loop preparation system comprises a chlorine absorption device, a caustic soda device, a magnesium hydroxide device, a magnesium oxide device, a calcium carbide device, an acetylene device, a VCM (Vinyl Chloride Monomer) device, a PVC (Polyvinyl Chloride) device, a C-PVC (Chlorinated Polyvinyl Chloride) device, an E-PVC (Emulsion Polyvinyl Chloride) device and a cement device, wherein the chlorine absorption device, the caustic soda device, the magnesium hydroxide device and the magnesium oxide device are connected together sequentially, a product of a front device is a raw material of a next device; the calcium carbide device, the acetylene device, the VCM device, the PVC device, the C-PVC device and the E-PVC device are also connected together sequentially, a product of a front device is a raw material of a next device; and calcium carbide slag produced by the acetylene device can be recycled as a raw material used for producing cement. With the adoption of the system and the method, polyvinyl chloride cleaning closed loop preparation of resource, production, product, consumption, waste recycling, production, product and consumption is realized, thus driving comprehensive development of multiple resources such as chloride, sodium, coal, limestone and the like, and constructing an integral industry chain of circular economy.