The invention discloses a P110 externally-thickened oil well tube and a manufacturing method thereof. The P110 externally-thickened oil well tube is prepared from 0.22%-0.32% of C, 0.15%-0.45% of Si, 1.00%-1.50% of Mn, not greater than 0.03% of P, not greater than 0.03% of S, and the balance of Fe and inevitable impurities. The manufacturing method of the P110 externally-thickened oil well tube comprises the following steps of performing converter smelting, performing external refining, performing billet continuous casting, performing round billet rolling, heating round billets in a ring-shaped furnace, performing tube penetrating in a fungoid type punching machine, rolling the tube in a continuous tube rolling machine, heading and externally thickening the tube end, and performing electric-induction quenching-and-tempering heat treatment. According to the P110 externally-thickened oil well tube and the manufacturing method thereof disclosed by the invention, low-cost C-Mn steel is adopted as a round billet raw material, and noble metals are not added, so that the alloy cost is low; moreover, the steel tube heating time is short, the efficiency is high, the energy is saved and, the consumption is reduced, and the manufacturing period is shortened.